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Omarigliptin Attenuates Rotenone-Induced Parkinson's Disease In Rats: Possible Role Of Oxidative Stress, Endoplasmic Reticulum Stress And Immune Modulation, Shereen Mowaka, Haidy E. Michel, Mariam M. Tadros, Moataz S. Hendy, Bassam M. Ayoub
Omarigliptin Attenuates Rotenone-Induced Parkinson's Disease In Rats: Possible Role Of Oxidative Stress, Endoplasmic Reticulum Stress And Immune Modulation, Shereen Mowaka, Haidy E. Michel, Mariam M. Tadros, Moataz S. Hendy, Bassam M. Ayoub
Pharmacy
The current study aimed to explore the potential neuroprotective effect of omarigliptin (OG), an antidiabetic drug that crosses the blood-brain barrier (BBB), in a Parkinson's disease (PD) rotenone-based rat-model. Results showed that OG attenuated motor impairment, histological aberrations, α-synuclein accumulation, and rescued the dopaminergic neurons in rotenone-administered rats. Furthermore, OG halted rotenone-induced oxidative stress; as shown by reduced lipid peroxidation, decline in the oxidative stress sensor (nuclear factor erythroid 2-related factor 2) and its downstream heme oxygenase-1. In addition, OG abrogated neuroinflammation and apoptosis in rotenone-treated rats. Moreover, OG ameliorated endoplasmic reticulum (ER) stress in rotenone-administered rats; as evidenced by …
Kinetic Degradation Study Of Ipragliflozin Coupled With Ms/Ms Structural Elucidation, Shereen Mowaka, Manar M. Elhassan,, Amr M. Mahmoud, Maha A. Hegazy
Kinetic Degradation Study Of Ipragliflozin Coupled With Ms/Ms Structural Elucidation, Shereen Mowaka, Manar M. Elhassan,, Amr M. Mahmoud, Maha A. Hegazy
Pharmacy
Ipragliflozin degradation behavior was studied under different conditions: acidic, basic, photolytic, oxidative and thermal degradation conditions. This forced degradation study showed the extensive degradation of Ipragliflozin under acidic, basic and oxidative conditions while showed high stability under thermal and photo-degradation conditions. The separation of Ipragliflozin and its degradation products was done using Hypersil Gold® UPLC C18 column with 1.9 μm particle size (3 × 50 mm) as stationary phase and a mobile phase composed of acetonitrile: potassium monobasic phosphate buffer pH 3 (50:50; v/v) delivered at flow rate of 0.6 mL min−1. Validation of the proposed method was carried out …