Open Access. Powered by Scholars. Published by Universities.®
- Discipline
- Institution
Articles 1 - 5 of 5
Full-Text Articles in Medicine and Health Sciences
Epigenetic Dominance Of Prion Conformers, Eri Saijo, Hae-Eun Kang, Jifeng Bian, Kristi G. Bowling, Shawn Browning, Sehun Kim, Nora Hunter, Glenn C. Telling
Epigenetic Dominance Of Prion Conformers, Eri Saijo, Hae-Eun Kang, Jifeng Bian, Kristi G. Bowling, Shawn Browning, Sehun Kim, Nora Hunter, Glenn C. Telling
Microbiology, Immunology, and Molecular Genetics Faculty Publications
Although they share certain biological properties with nucleic acid based infectious agents, prions, the causative agents of invariably fatal, transmissible neurodegenerative disorders such as bovine spongiform encephalopathy, sheep scrapie, and human Creutzfeldt Jakob disease, propagate by conformational templating of host encoded proteins. Once thought to be unique to these diseases, this mechanism is now recognized as a ubiquitous means of information transfer in biological systems, including other protein misfolding disorders such as those causing Alzheimer's and Parkinson's diseases. To address the poorly understood mechanism by which host prion protein (PrP) primary structures interact with distinct prion conformations to influence pathogenesis, …
Asymmetric Dimethylarginine Blocks Nitric Oxide-Mediated Alcohol-Stimulated Cilia Beating., Todd A. Wyatt, S . M. Wells, Z . A. Alsaidi, Jane M. Devasure, E. B. Klein, Kristina L. Bailey, Joseph H. Sisson
Asymmetric Dimethylarginine Blocks Nitric Oxide-Mediated Alcohol-Stimulated Cilia Beating., Todd A. Wyatt, S . M. Wells, Z . A. Alsaidi, Jane M. Devasure, E. B. Klein, Kristina L. Bailey, Joseph H. Sisson
Journal Articles: Pulmonary & Critical Care Med
The airway epithelium is exposed to alcohol during drinking through direct exhalation of volatized ethanol from the bronchial circulation. Alcohol exposure leads to a rapid increase in the cilia beat frequency (CBF) of bronchial epithelial cells followed by a chronic desensitization of cilia stimulatory responses. This effect is governed in part by the nitric oxide regulation of cyclic guanosine and adenosine monophosphate-dependent protein kinases (PKG and PKA) and is not fully understood. Asymmetric dimethylarginine (ADMA), an endogenous inhibitor of nitric oxide synthase, is implicated in the pathogenesis of several pulmonary disorders. We hypothesized that the inhibition of nitric oxide synthase …
Cattle-Related Injuries And Farm Management Practices On Kentucky Beef Cattle Farms, Steven R. Browning, Susan C. Westneat, Wayne T. Sanderson, Deborah B. Reed
Cattle-Related Injuries And Farm Management Practices On Kentucky Beef Cattle Farms, Steven R. Browning, Susan C. Westneat, Wayne T. Sanderson, Deborah B. Reed
Epidemiology and Environmental Health Faculty Publications
While working on farms with livestock increases the risk of injury among farm workers in comparison to other commodity farms, few studies have examined the role offarm management practices in association with the risk of cattle-related injury. We examined the farm management practices of Kentucky beef cattle farms in association with self-reported rates of cattle-related injuries among workers. We conducted a mail survey of a random sample of 2,500 members of the Kentucky Cattlemen's Association. Results from 1,149 farm operators who were currently raising beef cattle and provided complete survey response are reported. During the busy season, the principal operator …
Draft Genome Sequence Of Ochrobactrum Pseudogrignonense Strain Cdb2, A Highly Efficient Arsenate-Resistant Soil Bacterium From Arsenic-Contaminated Cattle Dip Sites, Yiren Yang, Xuefei Yu, Ren Zhang
Draft Genome Sequence Of Ochrobactrum Pseudogrignonense Strain Cdb2, A Highly Efficient Arsenate-Resistant Soil Bacterium From Arsenic-Contaminated Cattle Dip Sites, Yiren Yang, Xuefei Yu, Ren Zhang
Faculty of Science, Medicine and Health - Papers: part A
We report the 4.97-Mb draft genome sequence of a highly efficient arsenate-resistant bacterium, Ochrobactrum sp. strain CDB2. It contains a novel arsenic resistance (ars) operon (arsR-arsC1-ACR3-arsC2-arsH-mfs) and two non-operon-associated ars genes, arsC3 and arsB. The genome information will aid in the understanding of the arsenic resistance mechanism of this and other bacterial species.
Accuracy Of Micrometeorological Techniques For Detecting A Change In Methane Emissions From A Herd Of Cattle, Johannes Laubach, Mei Bai, Cesar S. Pinares-Patino, Frances A. Phillips, Travis A. Naylor, German Molano, Edgar A. Cardenas Rocha, David W. T Griffith
Accuracy Of Micrometeorological Techniques For Detecting A Change In Methane Emissions From A Herd Of Cattle, Johannes Laubach, Mei Bai, Cesar S. Pinares-Patino, Frances A. Phillips, Travis A. Naylor, German Molano, Edgar A. Cardenas Rocha, David W. T Griffith
Faculty of Science, Medicine and Health - Papers: part A
Micrometeorological techniques are effective in measuring methane (CH4) emission rates at the herd scale, but their suitability as verification tools for emissions mitigation depends on the uncertainty with which they can detect a treatment difference. An experiment was designed to test for a range of techniques whether they could detect a change in weekly mean emission rate from a herd of cattle, in response to a controlled change in feed supply. The cattle were kept in an enclosure and fed pasture baleage, of amounts increasing from one week to the next. Methane emission rates were measured at the herd scale …