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Understanding The Molecular Mechanisms Underlying Complex Cancer Genome Rearrangements, Robert Hedlund, Vladimir N. Uversky

Molecular Medicine Faculty Publications

In their recent paper, Malhotra et al. performed a comprehensive analysis of the structural variation breakpoints in 64 cancer genomes from 7 tumor types to find the prevalence and origins of complex genomic rearrangements.1 Since this work represents a breakthrough in understanding of the molecular mechanisms underlying complex cancer genome rearrangements, we provide a brief overview of this outstanding study.