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Transcriptome Analysis Reveals New Insights Into The Modulation Of Endometrial Stromal Cell Receptive Phenotype By Embryo-Derived Signals Interleukin-1 And Human Chorionic Gonadotropin: Possible Involvement In Early Embryo Implantation, Amélie Bourdiec, Ezequiel Calvo, C. V. Rao, Ali Akoum
Transcriptome Analysis Reveals New Insights Into The Modulation Of Endometrial Stromal Cell Receptive Phenotype By Embryo-Derived Signals Interleukin-1 And Human Chorionic Gonadotropin: Possible Involvement In Early Embryo Implantation, Amélie Bourdiec, Ezequiel Calvo, C. V. Rao, Ali Akoum
HWCOM Faculty Publications
The presence of the conceptus in uterine cavity necessitates an elaborate network of interactions between the implanting embryo and a receptive endometrial tissue. We believe that embryo-derived signals play an important role in the remodeling and the extension of endometrial receptivity period. Our previous studies provided original evidence that human Chorionic Gonadotropin (hCG) modulates and potentiates endometrial epithelial as well as stromal cell responsiveness to interleukin 1 (IL1), one of the earliest embryonic signals, which may represent a novel pathway by which the embryo favors its own implantation and growth within the maternal endometrial host. The present study was designed …