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Development Of A Novel Aspirin Suppository Formulation And Evaluation Of The Acetylation Of Cox-1 Via A Ht-29/Caco-2 Cell Absorption Assay Used To Detect The Absorption Of Aspirin Formulated With Various Bases And Excipients, Tiffany J. Zehel, Danielle L. Eaton, Sarah A. Myers, Mallory J. Martin, Joseph D. Newman, Rocco J. Rotello, Miriam A. Ansong
Development Of A Novel Aspirin Suppository Formulation And Evaluation Of The Acetylation Of Cox-1 Via A Ht-29/Caco-2 Cell Absorption Assay Used To Detect The Absorption Of Aspirin Formulated With Various Bases And Excipients, Tiffany J. Zehel, Danielle L. Eaton, Sarah A. Myers, Mallory J. Martin, Joseph D. Newman, Rocco J. Rotello, Miriam A. Ansong
Pharmacy and Nursing Student Research and Evidence-Based Medicine Poster Session
As the baby-boomer population ages, hospitalization rates will rise, increasing the number of patients who are NPO. Research indicates that aspirin use also increases with advanced age. With the increased prevalence of this demographic, there continues to be a growing need for alternative dosage forms for aspirin administration. A common and limited-risk alternative is rectally administered aspirin. However, there appears to be only one commercially available aspirin suppository and it has yielded erratic results as shown in previous research.
Aspirin is considered a pro-drug; once it is inside the body, the acidic environment cleaves the aspirin molecule down to salicylic …