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Full-Text Articles in Medicine and Health Sciences
Relation Between Corticosterone And Fear-Related Behavior In Mice Selectively Bred For High Or Low Alcohol Preference, Julia Chester, Aaron M. Kirchhoff, Gustavo D. Barrenha
Relation Between Corticosterone And Fear-Related Behavior In Mice Selectively Bred For High Or Low Alcohol Preference, Julia Chester, Aaron M. Kirchhoff, Gustavo D. Barrenha
Department of Psychological Sciences Faculty Publications
Blunted cortisol responses to stress or trauma have been linked with genetic (familial) risk for both alcoholism and post-traumatic stress-disorder (PTSD). Mouse lines selectively bred for high (HAP) or low (LAP) alcohol preference may be a relevant model of genetic risk for co-morbid alcoholism and PTSD in humans. HAP mice show greater fear-potentiated startle (FPS), a model used to study PTSD, than LAP mice. The relation between corticosterone (CORT) and FPS behavior was explored in four experiments. Naïve male and female HAP2 and LAP2 mice received fear-conditioning or control treatments and CORT levels were measured before and immediately after fear-conditioning …
Nicotinic Acetylcholine Receptors Containing Α6 Subunits Contribute To Alcohol Reward-Related Behaviors, Matthew S. Powers, H. J. Broderick, Ryan M. Drenan, Julia Chester
Nicotinic Acetylcholine Receptors Containing Α6 Subunits Contribute To Alcohol Reward-Related Behaviors, Matthew S. Powers, H. J. Broderick, Ryan M. Drenan, Julia Chester
Department of Psychological Sciences Faculty Publications
Evidence is emerging that neuronal nicotinic acetylcholine receptors (nAChRs) in the mesolimbic dopamine (DA) system are involved in mediating the reinforcing effects of alcohol. Midbrain DA neurons express high levels of α6 subunit-containing nAChRs that modulate DA transmission, implicating their involvement in reward-related behaviors. The present study assessed the role of α6-containing nAChRs in modulating alcohol reward using transgenic mice expressing mutant, hypersensitive α6 nAChR subunits (α6L9′S mice). α6L9′S mice and littermate controls were tested in three well-established models of alcohol reward: 24-hr two-bottle choice drinking, drinking in the dark (DID), and conditioned place preference (CPP). Confocal microscopy and patch-clamp …