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Snp-Snp Interaction Network In Angiogenesis Genes Associated With Prostate Cancer Aggressiveness, Hui-Yi Lin, Ernest K. Amankwah, Tung-Sung Tseng, Xiaotao Qu, Dung-Tsa Chen, Jong Y. Park
Snp-Snp Interaction Network In Angiogenesis Genes Associated With Prostate Cancer Aggressiveness, Hui-Yi Lin, Ernest K. Amankwah, Tung-Sung Tseng, Xiaotao Qu, Dung-Tsa Chen, Jong Y. Park
School of Public Health Faculty Publications
Angiogenesis has been shown to be associated with prostate cancer development. The majority of prostate cancer studies focused on individual single nucleotide polymorphisms (SNPs) while SNP-SNP interactions are suggested having a great impact on unveiling the underlying mechanism of complex disease. Using 1,151 prostate cancer patients in the Cancer Genetic Markers of Susceptibility (CGEMS) dataset, 2,651 SNPs in the angiogenesis genes associated with prostate cancer aggressiveness were evaluated. SNP-SNP interactions were primarily assessed using the two-stage Random Forests plus Multivariate Adaptive Regression Splines (TRM) approach in the CGEMS group, and were then re-evaluated in the Moffitt group with 1,040 patients. …