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Full-Text Articles in Medicine and Health Sciences
Habituation And Prepulse Inhibition Of The Acoustic Startle In Rodents, Bridget Valsamis, Susanne Schmid
Habituation And Prepulse Inhibition Of The Acoustic Startle In Rodents, Bridget Valsamis, Susanne Schmid
Anatomy and Cell Biology Publications
The acoustic startle response is a protective response, elicited by a sudden and intense acoustic stimulus. Facial and skeletal muscles are activated within a few milliseconds, leading to a whole body flinch in rodents. Although startle responses are reflexive responses that can be reliably elicited, they are not stereotypic. They can be modulated by emotions such as fear (fear potentiated startle) and joy (joy attenuated startle), by non-associative learning processes such as habituation and sensitization, and by other sensory stimuli through sensory gating processes (prepulse inhibition), turning startle responses into an excellent tool for assessing emotions, learning, and sensory gating. …
Differential Expression Of Voltage-Gated K+ Currents In Medial Septum/Diagonal Band Complex Neurons Exhibiting Distinct Firing Phenotypes, Emilio R. Garrido-Sanabria, Miriam G. Perez-Cordova, Luis V. Colom
Differential Expression Of Voltage-Gated K+ Currents In Medial Septum/Diagonal Band Complex Neurons Exhibiting Distinct Firing Phenotypes, Emilio R. Garrido-Sanabria, Miriam G. Perez-Cordova, Luis V. Colom
Health & Biomedical Sciences Faculty Publications and Presentations
The medial septum/diagonal band complex (MSDB) controls hippocampal excitability, rhythms and plastic processes. Medial septal neuronal populations display heterogeneous firing patterns. In addition, some of these populations degenerate during age-related disorders (e.g. cholinergic neurons). Thus, it is particularly important to examine the intrinsic properties of theses neurons in order to create new agents that effectively modulate hippocampal excitability and enhance memory processes. Here, we have examined the properties of voltage-gated, K+ currents in electrophysiologically-identified neurons. These neurons were taken from young rat brain slices containing the MS/DB complex. Whole-cell, patch recordings of outward currents were obtained from slow firing, fast-spiking, …
The Influence Of Macrophage Depletion On Ligament Healing, Connie S. Chamberlain, Ellen M. Leiferman, Kayt E. Frisch, Sijian Wang, Xipei Yang, Nico Van Rooijen, Geoff S. Baer, Stacey L. Brickson, Ray Vanderby
The Influence Of Macrophage Depletion On Ligament Healing, Connie S. Chamberlain, Ellen M. Leiferman, Kayt E. Frisch, Sijian Wang, Xipei Yang, Nico Van Rooijen, Geoff S. Baer, Stacey L. Brickson, Ray Vanderby
Faculty Publications - Biomedical, Mechanical, and Civil Engineering
Despite a complex cascade of cellular events to reconstruct damaged extracellular matrix (ECM), ligament healing results in a mechanically inferior, scar-like tissue. During normal healing, the number of macrophages significantly increases within the wound site. Then, granulation tissue expands into any residual, normal ligamentous tissue (creeping substitution), resulting in a larger region of healing, greater mechanical compromise, and an inefficient repair process. To study the effects of macrophages on the repair process, bilateral, surgical rupture of their medial collateral ligaments (MCLs) was done on rats. Treatment animals received liposome-encapsulated clodronate, 2 days before rupture to ablate phagocytosing macrophages. Ligaments were …
Modulation Of Myocardial Mitochondrial Mechanisms During Severe Polymicrobial Sepsis In The Rat, M. Chopra, H. B. Golden, S. Mullapudi, W. Dowhan, D. E. Dostal, Avadhesh C. Sharma
Modulation Of Myocardial Mitochondrial Mechanisms During Severe Polymicrobial Sepsis In The Rat, M. Chopra, H. B. Golden, S. Mullapudi, W. Dowhan, D. E. Dostal, Avadhesh C. Sharma
PCOM Scholarly Papers
Background: We tested the hypothesis that 5-Hydroxydecanoic acid (5HD), a putative mitoKATP channel blocker, will reverse sepsis-induced cardiodynamic and adult rat ventricular myocyte (ARVM) contractile dysfunction, restore mitochondrial membrane permeability alterations and improve survival. Methodology/Principal Findings: Male Sprague-Dawley rats (350-400 g) were made septic using 400 mg/kg cecal inoculum, ip. Sham animals received 5% dextrose water, ip. The Voltage Dependent Anion Channels (VDAC1), Bax and cytochrome C levels were determined in isolated single ARVMs obtained from sham and septic rat heart. Mitochondria and cytosolic fractions were isolated from ARVMs treated with norepinephrine (NE, 10 µmoles) in the presence/absence of 5HD …