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Articles 1 - 16 of 16
Full-Text Articles in Medicine and Health Sciences
Habitual Chocolate Intake And Type 2 Diabetes Mellitus In The Maine-Syracuse Longitudinal Study: (1975-2010): Prospective Observations, Georgina E. Crichton, Merrill F. Elias, Peter J. Dearborn Ma, Michael A. Robbins
Habitual Chocolate Intake And Type 2 Diabetes Mellitus In The Maine-Syracuse Longitudinal Study: (1975-2010): Prospective Observations, Georgina E. Crichton, Merrill F. Elias, Peter J. Dearborn Ma, Michael A. Robbins
Maine-Syracuse Longitudinal Papers
Compounds in cocoa and chocolate have established cardiovascular benefits, including beneficial effects on insulin resistance, a risk factor for type 2 diabetes mellitus. The aims of this study was to investigate relations between habitual chocolate intakes and diabetes mellitus. Cross-sectional and prospective analyses were undertaken on 953 community-dwelling participants (mean age 62 years, 59% women) from the Maine-Syracuse Longitudinal Study (MSLS). Habitual chocolate intakes, measured using a food frequency questionnaire, were related to prevalence of diabetes mellitus (cross-sectionally) and with risk of diabetes measured approximately five years later (prospectively). We also examined the relation between diabetes (the predictor) and chocolate …
Relation Of Habitual Chocolate Consumption To Arterial Stiffness In A Community-Based Sample: Preliminary Findings, Georgina E. Crichton, Merrill F. Elias, Ala’A Alkerwi, Walter P. Abhayaratna
Relation Of Habitual Chocolate Consumption To Arterial Stiffness In A Community-Based Sample: Preliminary Findings, Georgina E. Crichton, Merrill F. Elias, Ala’A Alkerwi, Walter P. Abhayaratna
Maine-Syracuse Longitudinal Papers
No abstract provided.
Daily Chocolate Consumption Is Inversely Associated With Insulin Resistance And Liver Enzymes In The Observation Of Cardiovascular Risk Factors Study, Ala’A Alkerwi, Nicolas Sauvegeot, Georgina E. Crichton, Merrill F. Elias, Saverio Stranges
Daily Chocolate Consumption Is Inversely Associated With Insulin Resistance And Liver Enzymes In The Observation Of Cardiovascular Risk Factors Study, Ala’A Alkerwi, Nicolas Sauvegeot, Georgina E. Crichton, Merrill F. Elias, Saverio Stranges
Maine-Syracuse Longitudinal Papers
This study examined the association of chocolate consumption with insulin resistance and serum liver enzymes in a national sample of adults in Luxembourg. A random sample of 1153 individuals, aged 18–69 years, was recruited to participate in the cross-sectional Observation of Cardiovascular Risk Factors in Luxembourg study. Chocolate consumption (g/d) was obtained from a semi-quantitative FFQ. Blood glucose and insulin levels were used for the homoeostasis model assessment of insulin resistance (HOMA-IR). Hepatic biomarkers such as serum γ-glutamyl-transpeptidase (γ-GT), serum aspartate transaminase and serum alanine transaminase (ALT) (mg/l) were assessed using standard laboratory assays. Chocolate consumers (81·8 %) were more …
Sugar-Sweetened Soft Drinks Are Associated With Poorer Cognitive Function In Individuals With Type 2 Diabetes: The Maine-Syracuse Longitudinal Study, Georgina E. Crichton, Merrill F. Elias, Rachael V. Torres
Sugar-Sweetened Soft Drinks Are Associated With Poorer Cognitive Function In Individuals With Type 2 Diabetes: The Maine-Syracuse Longitudinal Study, Georgina E. Crichton, Merrill F. Elias, Rachael V. Torres
Maine-Syracuse Longitudinal Papers
The importance of adequate nutrition on cognitive performance is well recognised. Greater intakes of soft drinks are associated with a higher risk for type 2 diabetes, as well as other cardiometabolic diseases. A few studies have specifically examined whether the intake of soft drinks may be related to cognitive function. The aim of this study was to investigate whether soft drink intakes, including both sugar-sweetened and diet beverages, are associated with cognitive function, with adjustment for cardiovascular, lifestyle and dietary factors, and stratified according to type 2 diabetes status. Cross-sectional analyses were undertaken using 803 community-dwelling participants, aged 23–98 years, …
Dairy Consumption And Hypertension: Arterial Stiffness And Pulse Pressure, Merrill F. Elias, Gregory A. Dore, Georgina E. Crichton
Dairy Consumption And Hypertension: Arterial Stiffness And Pulse Pressure, Merrill F. Elias, Gregory A. Dore, Georgina E. Crichton
Maine-Syracuse Longitudinal Papers
No abstract provided.
Hypertension And Cognitive Functioning: A Perspective In Historical Context, Merrill F. Elias, Amanda L. Goodell, Gregory A. Dore
Hypertension And Cognitive Functioning: A Perspective In Historical Context, Merrill F. Elias, Amanda L. Goodell, Gregory A. Dore
Maine-Syracuse Longitudinal Papers
Our objective is to characterize the development of the literature on hypertension and cognitive functioning from a historical perspective. This goal was stimulated by the review on “Historical Trends and Milestones in Hypertension Research” in the October 2012 issue of Hypertension. Our specific aims are threefold: (1) to trace and describe the history of this area of research; (2) to identify milestones in knowledge and methods; and (3) to discuss briefly how this literature translates into patient care. The topic is of major relevance to research and practice because hypertension is a well-known risk factor for decline in cognitive performance …
From Blood Pressure To Physical Disability: The Role Of Cognition, Merrill F. Elias, Gregory A. Dore, Adam Davey, Michael A. Robbins, Penelope K. Elias
From Blood Pressure To Physical Disability: The Role Of Cognition, Merrill F. Elias, Gregory A. Dore, Adam Davey, Michael A. Robbins, Penelope K. Elias
Maine-Syracuse Longitudinal Papers
We examined the hypothesis that lowered cognitive performance plays a role in the relation between elevated blood pressure and physical disability in performing basic physical tasks. A community-based sample (N = 1025) free from stroke and dementia (mean age: 61.1 years; SD: 13.0 years; 59.8% women) was used. Using path analysis, systolic and diastolic blood pressures (predictor variable) measured over multiple longitudinal examinations were averaged and related to multiple measures of cognition (intermediate variable) and physical ability (PA; outcome variable) measured at wave 6 of the Maine-Syracuse Study. PA was indexed by time required to execute standing, walking, and turning …
Arterial Pulse Wave Velocity And Cognition With Advancing Age, Merrill F. Elias, Michael A. Robbins, Marc M. Budge, Walter P. Abhayaratna, Gregory A. Dore, Penelope K. Elias
Arterial Pulse Wave Velocity And Cognition With Advancing Age, Merrill F. Elias, Michael A. Robbins, Marc M. Budge, Walter P. Abhayaratna, Gregory A. Dore, Penelope K. Elias
Maine-Syracuse Longitudinal Papers
We hypothesized that carotid-femoral pulse wave velocity (PWV), a marker of arterial stiffness, interacts with age such that the magnitude of associations between PWV and cognitive performance are greater with increasing age and that this interaction is observed despite adjustments for demographic variables, mean arterial pressure, and cardiovascular risk factors. PWV was estimated using applanation tonometry in 409 dementia- and stroke-free participants of the Maine-Syracuse Longitudinal Study (24 to 92 years of age; 62.3% women). Using linear regression analyses in a cross-sectional design, associations between PWV and age and the interaction of PWV and age were examined in relation to …
Chronic Kidney Disease, Creatinine And Cognitive Functioning, Merrill F. Elias, Penelope K. Elias, Stephen L. Seliger, Sriram S. Narsipur, Gregory A. Dore, Michael A. Robbins
Chronic Kidney Disease, Creatinine And Cognitive Functioning, Merrill F. Elias, Penelope K. Elias, Stephen L. Seliger, Sriram S. Narsipur, Gregory A. Dore, Michael A. Robbins
Maine-Syracuse Longitudinal Papers
Background. Non-dialysis-dependent chronic kidney dis- ease (CKD) is related to cognitive impairment. Previous studies have not explored the extent of impairment across multiple cognitive domains. We examined the range of specific cognitive abilities affected by CKD and whether the associations of CKD with cognition were eliminated by statistical control for cardiovascular disease correlates of CKD. Methods. We performed a community-based cross-sectional study with 923 individuals free from dementia and end-stage renal disease. Two groups were defined based on estimated glomerular filtration rate (eGFR): eGFR/min/1.73 m2 versus eGFR≥60 mL/min/1.73 m2. Out- come measures were scores from multiple clinical tests of specific …
Blood Pressure And Disability: First Steps In Future Studies, Michael A. Robbins, Penelope K. Elias, Merrill F. Elias
Blood Pressure And Disability: First Steps In Future Studies, Michael A. Robbins, Penelope K. Elias, Merrill F. Elias
Maine-Syracuse Longitudinal Papers
No abstract provided.
Homocysteine, Folate, And Vitamins B6 And B12 Blood Levels In Relation To Cognitive Performance: The Maine-Syracuse Study, Merrill F. Elias, Michael A. Robbins, Marc M. Budge, Penelope K. Elias, Suzanne L. Brennan, Carole Johnston, Zsuzsanna Nagy, Christopher J. Bates
Homocysteine, Folate, And Vitamins B6 And B12 Blood Levels In Relation To Cognitive Performance: The Maine-Syracuse Study, Merrill F. Elias, Michael A. Robbins, Marc M. Budge, Penelope K. Elias, Suzanne L. Brennan, Carole Johnston, Zsuzsanna Nagy, Christopher J. Bates
Maine-Syracuse Longitudinal Papers
Objective: Our objective was to examine associations among plasma homocysteine concentrations (tHcy), the tHcy-cofactors (folate, vitamins B6 and B12), and multiple domains of cognitive performance, with statistical adjustment for possible confounds, including cardiovascular disease risk factors (CVD-RF) and cardiovascular disease (CVD). Methods: Subjects were 812 partici- pants (58% women) of the Maine-Syracuse study who were free of dementia and stroke. Employing a cross-sectional design and multiple regression analyses, fasting concentrations of tHcy and its vitamin cofactors (folate, B6, and B12) were related to multiple domains of cognitive performance. Results: With adjustment for age, education, gender, ethnicity, and the …
Blood Pressure And Cognitive Function In An African-American And A Caucasian-American Sample: The Maine-Syracuse Study, Michael A. Robbins, Merrill F. Elias, Penelope K. Elias, Marc M. Budge
Blood Pressure And Cognitive Function In An African-American And A Caucasian-American Sample: The Maine-Syracuse Study, Michael A. Robbins, Merrill F. Elias, Penelope K. Elias, Marc M. Budge
Maine-Syracuse Longitudinal Papers
Objective: The primary purpose of this study was to examine associations between indices of blood pressure (BP) and cognitive function for African-American participants in the Maine-Syracuse Longitudinal Study (MSLS). Corresponding data for the Caucasian-American MSLS participants were included to provide a basis for comparison. Interactions of age with BP indices were also assessed in relation to cognitive function. Methods: Data were drawn from the baseline MSLS questionnaires, medical interviews and examinations, Wechsler Adult Intelligence Scale subtests, and measurements of BP for 1563 participants, of whom 147 were African American. Multiple linear regression analyses were employed to examine the relationship between …
Serum Cholesterol And Cognitive Performance In The Framingham Heart Study, Penelope K. Elias, Merrill F. Elias, Ralph B. D'Agostino, Lisa M. Sullivan, Philip A. Wolf
Serum Cholesterol And Cognitive Performance In The Framingham Heart Study, Penelope K. Elias, Merrill F. Elias, Ralph B. D'Agostino, Lisa M. Sullivan, Philip A. Wolf
Maine-Syracuse Longitudinal Papers
Objective: The objective of this study was to examine the relationship between total cholesterol (TC) and cognitive performance within the context of the Framingham Heart Study, a large, community-based, prospective investigation of cardiovascular risk factors. Methods: Participants were 789 men and 1105 women from the Framingham Heart Study original cohort who were free of dementia and stroke and who received biennial TC determinations over a 16- to 18-year surveillance period. Cognitive tests were administered 4 to 6 years subsequent to the surveillance period and consisted of measures of learning, memory, attention/ concentration, abstract reasoning, concept formation, and organizational abilities. Statistical …
Low Blood Pressure And Depression: Comorbidity And Competing Outcomes, Michael A. Robbins, Penelope K. Elias, Merrill F. Elias
Low Blood Pressure And Depression: Comorbidity And Competing Outcomes, Michael A. Robbins, Penelope K. Elias, Merrill F. Elias
Maine-Syracuse Longitudinal Papers
No abstract provided.
Effects Of Antihypertensive Medications On Quality Of Life In Elderly Hypertensive Women, Sydney H. Croog, Merrill F. Elias, Theodore Colton, Robert M. Baume, Sandra R. Leiblum, C David Jones, H Mitchell Perry, W Dallas Hall
Effects Of Antihypertensive Medications On Quality Of Life In Elderly Hypertensive Women, Sydney H. Croog, Merrill F. Elias, Theodore Colton, Robert M. Baume, Sandra R. Leiblum, C David Jones, H Mitchell Perry, W Dallas Hall
Maine-Syracuse Longitudinal Papers
The impact of antihypertensive medications on the quality of life of elderly hypertensive women has rarely been systematically evaluated in large clinical trials using drugs from the new generations of pharmaceutic preparations. We carried out a multicenter, randomized double-blind clinical trial with 309 hypertensive women aged 60 to 80 years to assess effects of atenolol, enalapril, and isradipine on measures of quality of life over a 22-week period. The patients had mild to moderate hypertension. Hydrochlorothiazide was added to treatment if monotherapy was inadequate in lowering blood pressure. At the conclusion of the trial the three drug groups did not …
Relationship Of Age And Hypertension To Neuropsychological Test Performance, Clyde A. Pentz Iii, Merrill F. Elias, W Gibson Wood, Norman A. Schultz, John Dineen
Relationship Of Age And Hypertension To Neuropsychological Test Performance, Clyde A. Pentz Iii, Merrill F. Elias, W Gibson Wood, Norman A. Schultz, John Dineen
Maine-Syracuse Longitudinal Papers
Young adult (X- = 29) and middle aged (X- =50) hypertensive and normotensive subjects were compared with respect to seven neuropsychological test scores derived from tests on the Halstead-Reitan battery. Age main effects, with inferior performance for the middle aged subjects, were observed for the localization and time portions of the Tactile Performance Test (TPT) and for the Trail Making A test. The multivariate age effect was significant for the composite of seven scores. A multivariate blood pressure main effect was obtained and main effect blood pressure was significant for the category test; hypertensives made more errors than normotensives. A …