Medicine and Health Sciences Commons^™

Rapamycin Rescues Vascular, Metabolic And Learning Deficits In Apolipoprotein E4 Transgenic Mice With Pre-Symptomatic Alzheimer’S Disease, Ai-Ling Lin, Jordan B. Jahrling, Wei Zhang, Nicholas Derosa, Vikas Bakshi, Peter Romero, Veronica Galvan, Arlan Richardson

Sanders-Brown Center on Aging Faculty Publications

Apolipoprotein E ɛ4 allele is a common susceptibility gene for late-onset Alzheimer's disease. Brain vascular and metabolic deficits can occur in cognitively normal apolipoprotein E ɛ4 carriers decades before the onset of Alzheimer's disease. The goal of this study was to determine whether early intervention using rapamycin could restore neurovascular and neurometabolic functions, and thus impede pathological progression of Alzheimer's disease-like symptoms in pre-symptomatic Apolipoprotein E ɛ4 transgenic mice. Using in vivo, multimodal neuroimaging, we found that apolipoprotein E ɛ4 mice treated with rapamycin had restored cerebral blood flow, blood–brain barrier integrity and glucose metabolism, compared …

Research Brief: "Military Service Absences And Family Members’ Mental Health: A Timeline Followback Assessment", Institute For Veterans And Military Families At Syracuse University

Institute for Veterans and Military Families

This brief examines mental health correlating with a parent's absence during a military deployment. The findings show that adolescents were affected by a military parent being absent from significant events, and that they would benefit from programs that offer pre and post-deployment briefings. In the future, research should investigate how contact during military deployment affects the service member and their family.

Mice Deficient In Endothelial Α5 Integrin Are Profoundly Resistant To Experimental Ischemic Stroke, Jill Roberts, Leon De Hoog, Gregory J. Bix

Sanders-Brown Center on Aging Faculty Publications

Stroke is a disease in dire need of better therapies. We have previously shown that a fragment of the extracellular matrix proteoglycan, perlecan, has beneficial effects following cerebral ischemia via the α5β1 integrin receptor. We now report that endothelial cell selective α5 integrin deficient mice (α5 KO) are profoundly resistant to ischemic infarct after transient middle cerebral artery occlusion. Specifically, α5 KOs had little to no infarct 2–3 days post-stroke, whereas controls had an increase in mean infarct volume over the same time period as expected. Functional outcome is also improved in the α5 KOs compared with controls. Importantly, no …

Early Shifts Of Brain Metabolism By Caloric Restriction Preserve White Matter Integrity And Long-Term Memory In Aging Mice, Janet Guo, Vikas Bakshi, Ai-Ling Lin

Sanders-Brown Center on Aging Faculty Publications

Preservation of brain integrity with age is highly associated with lifespan determination. Caloric restriction (CR) has been shown to increase longevity and healthspan in various species; however, its effects on preserving living brain functions in aging remain largely unexplored. In the study, we used multimodal, non-invasive neuroimaging (PET/MRI/MRS) to determine in vivo brain glucose metabolism, energy metabolites, and white matter structural integrity in young and old mice fed with either control or 40% CR diet. In addition, we determined the animals’ memory and learning ability with behavioral assessments. Blood glucose, blood ketone bodies, and body weight were also measured. We …

Maternal Health In Villages Of Northern Uttar Pradesh Assessing Options, Practices And Outcomes In Bahraich District, Elizabeth Curtis

India: Public Health, Policy Advocacy, and Community

Maternal mortality distinctly highlights a health burden women face, particularly in developing countries. For that reason, poor maternal outcomes in rural India are a field in which Public Health workers and researchers continue to question and study. This project aims to understand the reasons behind poor maternal health outcomes for village women in Bahraich District of Uttar Pradesh. The focus of this topic is the accessibility of available health services and the attitudes of various players who distribute or consume services of the health system. Through fieldwork with doctors, medical institutions, auxiliary health workers, traditional health workers, and village women, …

Cross-Cultural Childbirth: Prioritizing The Healthcare Experiences Of Migrant Women In Competent Models Of Care, Emma Hall

Independent Study Project (ISP) Collection

In the context of the feminization of increasing global migration, it is impossible to understand maternal and child health in a given country without considering the experience of female migrants. As the total migrant population increases in the European Union, migration and its effects on health care provision in receiving countries and the experiences of immigrant populations must be recognized. Past research exposes an increased risk of complications and maternal mortality in migrant populations, but little information exists on the tangible programs that could respond to disparity. According to the World Health Organization, maternal health refers to the health of …

La Relación Entre El Desamparo Y La Salud: El Caso Del Campamento Japón En Santiago, Chile, Chaveli Concepción

Independent Study Project (ISP) Collection

En esta investigación se busca exponer más a fondo como la desigualdad social afecta la salud de aquellos que han sido menos favorecidos. En esta ocasión se analizó el caso de los habitantes del Campamento Japón, en la comuna de Maipú, de Santiago, Chile, con el objetivo de entender el fenómeno de la desigualdad social y cómo esta afecta la salud de las personas que la sufren. La metodología de este estudio cualitativo se constituyó de investigación bibliográfica previa, y posteriormente visitas y trabajos voluntarios al Campamento Japón para hacer observaciones y entrevistas a los activistas del campamento, a los …

La Santé Maternelle À Antsiranana Selon La Médicine Occidentale Et La Médicine Traditionnelle : Une Étude Des Traitements Opposés Pour Les Femmes Enceintes, Lauren Nguyen

Independent Study Project (ISP) Collection

Dans un pays comme le Madagascar, où des coutumes traditionnelles et le lien avec les ancêtres demeurent une grande partie de la culture, l’introduction des aspects « occidentales » présente un peu du désaccord. Cela est vu avec l’introduction de la médecine « occidentale », et le choix que font des Malagasy pour leurs soins médicaux. Spécifiquement dans le secteur de la médecine, la tension entre des pratiques occidentales et des pratiques traditionnelles est significative.

La présence des guérisseurs traditionnels et de la médecine traditionnelle sur l’île existait bien avant l’introduction de la médecine occidentale. Bien que de plus en …

How We Saved Ourselves: A Look At The Positive Coping Strategies The Orphans Of The 1994 Genocide Against Tutsis Implemented During Bereavement, Gregory Barber

Independent Study Project (ISP) Collection

Recent estimates report that there are approximately 145 million children worldwide who have lost at least one parent as a result of various causes (Development, 2008). Parental death is one of the most traumatic events that can occur in childhood (Haine, 2006). Literature has also indicated that parental death places children at risk for many negative outcomes, including mental health problems, grief, lower academic success, self-esteem, and greater external locus of control (Lutzke, 1997). Between April and July 1994, 800,000 to 1,000,000 Rwandans died in the 1994 genocide against Tutsis. Because of the 1994 genocide against Tutsis, nearly 75,000 children …

Las Percepciones De Los Profesionales De La Salud Sobre Los Cuidados Paliativos En Diferentes Sectores De Salud En La Ciudad De Buenos Aires / Perceptions Of Health Professionals About Palliative Care In Different Health Sectors In The City Of Buenos Aires, Kate Paulsen

Independent Study Project (ISP) Collection

Información contextual: Los cuidados paliativos son un campo de medicina para pacientes con enfermedades avanzadas o terminales. El propósito de la medicina paliativa es mejorar la calidad de vida de los pacientes y su familia y cuidar los síntomas físicos, psicológicos, sociales y espirituales. Los equipos interdisciplinarios compuestos de médicos, enfermeros, trabajadores sociales, psicólogos y otros tienen un papel esencial en el cuidado del paciente en una manera completa. Los cuidados paliativos son importantes porque todos tienen el derecho a ser acompañados en el final de la vida. En Argentina, los cuidados paliativos se han desarrollado considerablemente y existen en …

Abortion In Brazil - Todo Mundo Faz: An Analysis Of Social Movements And Social Support For The Liberalization Of Brazil’S Abortion Law In Salvador, Brazil, Maria Camila Caicedo

Independent Study Project (ISP) Collection

This study analyzed the current actions of feminist movements, black women’s movements, and other advocacy groups that have a stake in the current debate for the legalization of abortion in Brazil. The purpose of the study was to assess the current political avenues for approaching the legislative body available to marginalized groups who are disproportionately affected by the criminalization of abortion. It was built upon a comprehensive review of existing literature, which found very little information on the actions of feminist movements and black women’s movements in Northeast Brazil. The study was conducted over the course of four weeks in …

Exploring Community Health Through The Lens Of The Community Unit In Kariobangi North And The Surrounding Areas, Maya Paris-Saper

Independent Study Project (ISP) Collection

Healthcare is a challenge in countries of the Global South. Not only do climates and trends of rapid urbanization affect the health status of many negatively, but also many health facilities are inaccessible and not of good quality, they lack enough medical personnel and lack the resources to adequately provide for patients who do not have the resources them selves. As the wealth gap increases all over the world and resources continue to be distributed unequally communicable and non-communicable health issues plague those in urban and rural settings at an alarmingly high rate and as health innovation has worked to …

The Struggle Overseas: Risk Factors For Suicide Among Female Migrant Workers In Nepal, Dhara Puvar

Independent Study Project (ISP) Collection

This study aims to understand the various risk factors for suicide among female migrant workers in Nepal. Suicide is the leading cause of death among women in the country, and the prevalence of suicide among migrant women in particular warrants further investigation, especially considering the increasing number of women traveling abroad for foreign employment. What experiences do these women have that would lead to suicidal behavior? What personal and institutional challenges contribute to increased risk of suicide? How does the community respond to their needs? This research was conducted in the Kathmandu Valley, with the majority of data acquired through …

Time-Dependent Effects Of Cx3cr1 In A Mouse Model Of Mild Traumatic Brain Injury, Heidi Y. Febinger, Hannah E. Thomasy, Maria N. Pavlova, Kristyn M. Ringgold, Paulien R. Barf, Amrita M. George, Jenna N. Grillo, Adam D. Bachstetter, Jenny A. Garcia, Astrid E. Cardona, Mark R. Opp, Carmelina Gemma

Sanders-Brown Center on Aging Faculty Publications

BACKGROUND: Neuroinflammation is an important secondary mechanism that is a key mediator of the long-term consequences of neuronal injury that occur in traumatic brain injury (TBI). Microglia are highly plastic cells with dual roles in neuronal injury and recovery. Recent studies suggest that the chemokine fractalkine (CX3CL1, FKN) mediates neural/microglial interactions via its sole receptor CX3CR1. CX3CL1/CX3CR1 signaling modulates microglia activation, and depending upon the type and time of injury, either protects or exacerbates neurological diseases.

METHODS: In this study, mice deficient in CX3CR1 were subjected to mild controlled cortical impact injury (CCI), a model of TBI. We evaluated …

Albumin Administration In Acute Ischemic Stroke: Safety Analysis Of The Alias Part 2 Multicenter Trial, Michael D. Hill, Renee H. Martin, Yuko Y. Palesch, Claudias S. Moy, Diego Tamariz, Karla J. Ryckborst, Elizabeth B. Jones, David Weisman, L. Creed Pettigrew, Myron D. Ginsberg

Sanders-Brown Center on Aging Faculty Publications

BACKGROUND: Albumin treatment of ischemic stroke was associated with cardiopulmonary adverse events in previous studies and a low incidence of intracranial hemorrhage. We sought to describe the neurological and cardiopulmonary adverse events in the ALIAS Part 2 Multicenter Trial.

METHODS: Ischemic stroke patients, aged 18-83 and a baseline NIHSS ≥ 6, were randomized to treatment with ALB or saline control within 5 hours of stroke onset. Neurological adverse events included symptomatic intracranial hemorrhage, hemicraniectomy, neurological deterioration and neurological death. Cardiopulmonary adverse events included pulmonary edema/congestive heart failure, acute coronary syndromes, atrial fibrillation, pneumonia and pulmonary thromboembolism.

RESULTS: …

Maine Head Start And Early Head Start Needs Assessment Report 2015 Annual Update, Linda Labas, Jill Downs

Early Childhood Resources

The Maine Head Start and Early Head Start Needs Assessment Report 2015 Annual Update presents findings from a broad survey of directors and staff representing the 11 non-tribal Head Start grantees in Maine. This report serves as one source of information from which to assess partnerships and develop a strategic plan for the MHSSCO to enhance collaboration with other Maine early childhood system partners to support families and children in Maine.

Altered Lysosomal Proteins In Neural-Derived Plasma Exosomes In Preclinical Alzheimer Disease, Edward J. Goetzl, Adam Boxer, Janice B. Schwartz, Erin L. Abner, Ronald C. Petersen, Bruce L. Miller, Dimitrios Kapogiannis

Sanders-Brown Center on Aging Faculty Publications

OBJECTIVE: Diverse autolysosomal proteins were quantified in neurally derived blood exosomes from patients with Alzheimer disease (AD) and controls to investigate disordered neuronal autophagy.

METHODS: Blood exosomes obtained once from patients with AD (n = 26) or frontotemporal dementia (n = 16), other patients with AD (n = 20) both when cognitively normal and 1 to 10 years later when diagnosed, and case controls were enriched for neural sources by anti-human L1CAM antibody immunoabsorption. Extracted exosomal proteins were quantified by ELISAs and normalized with the CD81 exosomal marker.

RESULTS: Mean exosomal levels of cathepsin D, lysosome-associated membrane …

Low Neural Exosomal Levels Of Cellular Survival Factors In Alzheimer's Disease, Edward J. Goetzl, Adam Boxer, Janice B. Schwartz, Erin Abner, Ronald C. Petersen, Bruce L. Miller, Olga D. Carlson, Maja Mustapic, Dimitrios Kapogiannis

Sanders-Brown Center on Aging Faculty Publications

Transcription factors that mediate neuronal defenses against diverse stresses were quantified in plasma neural-derived exosomes of Alzheimer's disease or frontotemporal dementia patients and matched controls. Exosomal levels of low-density lipoprotein receptor-related protein 6, heat-shock factor-1, and repressor element 1-silencing transcription factor all were significantly lower in Alzheimer's disease patients than controls (P < 0.0001). In frontotemporal dementia, the only significant difference was higher levels of repressor element 1-silencing transcription factor than in controls. Exosomal transcription factors were diminished 2-10 years before clinical diagnosis of Alzheimer's disease. Low exosomal levels of survival proteins may explain decreased neuronal resistance to Alzheimer's disease neurotoxic proteins.

Research Brief: "Coping, Family Social Support, And Psychological Symptoms Among Student Veterans", Institute For Veterans And Military Families At Syracuse University

Institute for Veterans and Military Families

This study is about coping styles among student veterans and what is related to various coping styles. For policy and practice, universities should understand veterans' stigmatization of mental health services and should improve cultural competence; the Department of Veterans Affairs should work with universities to ensure student veteran success. Suggestions for future research include using a larger, more representative sample and looking at the effects of actual versus perceived social support.

Apoε2 And Education In Cognitively Normal Older Subjects With High Levels Of Ad Pathology At Autopsy: Findings From The Nun Study, Diego Iacono, Peter Zandi, Myron Gross, William R. Markesbery, Olga Pletnikova, Gay Rudow, Juan C. Troncoso

Sanders-Brown Center on Aging Faculty Publications

Asymptomatic Alzheimer's disease (ASYMAD) subjects are individuals characterized by preserved cognition before death despite substantial AD pathology at autopsy. ASYMAD subjects show comparable levels of AD pathology, i.e. β-amyloid neuritic plaques (Aβ-NP) and tau-neurofibrillary tangles (NFT), to those observed in mild cognitive impairment (MCI) and some definite AD cases. Previous clinicopathologic studies on ASYMAD subjects have shown specific phenomena of hypertrophy in the cell bodies, nuclei, and nucleoli of hippocampal pyramidal neurons and other cerebral areas. Since it is well established that the allele APOε4 is a major genetic risk factor for AD, we examined whether specific alleles of APOE …

Calcium Channel Blockers, Progression To Dementia, And Effects On Amyloid Beta Peptide Production, Mark A. Lovell, Erin Abner, Richard Kryscio, Liou Xu, Shuling X. Fister, Bert C. Lynn

Sanders-Brown Center on Aging Faculty Publications

Previous epidemiologic studies suggest that antihypertensive drugs may be protective against cognitive decline. To determine if subjects enrolled in the University of Kentucky longitudinal aging study who used antihypertensive drugs showed diminished progression to dementia, we used a 3-parameter logistic regression model to compare the rate of progression to dementia for subjects who used any of the five common categories of antihypertensive drugs to those with similar demographic characteristics but who did not use antihypertensives. Regression modeling showed that subjects who used calcium channel blockers (CCBs) but not the other classes of antihypertensives showed a significant decrease in the rate …

Review Of Edison Bicudo, Pharmaceutical Research, Democracy And Conspiracy: International Clinical Trials In Local Medical Institutions, Roberto Abadie

Department of Sociology: Faculty Publications

The pharmaceutical industry is—along with the financial and weapons industries—one of the most globalized and profitable business domains. But they wouldn’t make any profits if they weren’t able to recruit research subjects to test an increasing number of drugs. This global trial economy creates its own assemblages of clinical trials, often run by hired contract research organizations (CROs), who fight among each other in a rat-race competition, promising quick and effective trials; at the same time, enterprising countries, hospitals, and doctors jump on the drug trial economy bandwagon by promising quick, endless access to a large pool of research subjects, …

Associations Between Family Functioning And Adolescent Health Behaviors, Megan S. Fleming

Senior Honors Projects

Background: The obesity epidemic has been a concern across the globe, affecting about 20% of adolescents in the U.S. Physical activity and nutrition-related behaviors that develop during adolescence carry through into adulthood. Adolescents’ perceptions of how their family functions may be associated with health behaviors, including physical activity and diet.

Objective: To determine whether there is an association between perceived family functioning and adolescent health behaviors among a national sample of adolescents aged 11 to 16 who participated in the 2009-2010 Health Behaviors of School-Aged Children survey.

Methods: Participants reported on demographics and measures of family function, which included …

Closed Head Injury In An Age-Related Alzheimer Mouse Model Leads To An Altered Neuroinflammatory Response And Persistent Cognitive Impairment, Scott J. Webster, Linda J. Van Eldik, D. Martin Watterson, Adam D. Bachstetter

Sanders-Brown Center on Aging Faculty Publications

Epidemiological studies have associated increased risk of Alzheimer's disease (AD)-related clinical symptoms with a medical history of head injury. Currently, little is known about pathophysiology mechanisms linked to this association. Persistent neuroinflammation is one outcome observed in patients after a single head injury. Neuroinflammation is also present early in relevant brain regions during AD pathology progression. In addition, previous mechanistic studies in animal models link neuroinflammation as a contributor to neuropathology and cognitive impairment in traumatic brain injury (TBI) or AD-related models. Therefore, we explored the potential interplay of neuroinflammatory responses in TBI and AD by analysis of the temporal …

Attenuation Of Traumatic Brain Injury-Induced Cognitive Impairment In Mice By Targeting Increased Cytokine Levels With A Small Molecule Experimental Therapeutic, Adam D. Bachstetter, Scott J. Webster, Danielle S. Goulding, Jonathan E. Morton, D. Martin Watterson, Linda J. Van Eldik

Sanders-Brown Center on Aging Faculty Publications

BACKGROUND: Evidence from clinical studies and preclinical animal models suggests that proinflammatory cytokine overproduction is a potential driving force for pathology progression in traumatic brain injury (TBI). This raises the possibility that selective targeting of the overactive cytokine response, a component of the neuroinflammation that contributes to neuronal dysfunction, may be a useful therapeutic approach. MW151 is a CNS-penetrant, small molecule experimental therapeutic that selectively restores injury- or disease-induced overproduction of proinflammatory cytokines towards homeostasis. We previously reported that MW151 administered post-injury (p.i.) is efficacious in a closed head injury (CHI) model of diffuse TBI in mice. Here we test …

Cancer Treatment During Martha Mcmillan's Time (1913), Taylor L. Stephens

Martha McMillan Research Papers

No abstract provided.

California Trip (1904), Michael J. Newman

Martha McMillan Research Papers

No abstract provided.

Sexual And Reproductive Health Education For Boys In Kapchorwa, Uganda, Meredith Colleary

Independent Study Project (ISP) Collection

This study examines the systems by which adolescent boys receive sexual and reproductive health (SRH) education in Kapchorwa, Uganda. Teenage pregnancy and early marriage are epidemics that hinder Uganda’s development. As girls have consistently been the targets of interventions, this study considers how boys are included in these strategies. The objectives of the study are three-­‐fold: to research the ways that boys receive SRH education, to identify the successes and shortcomings of these education systems, and to seek ways for these systems to be improved.

The study was carried out over a six-­‐week period in the spring of 2015. The …

Mind Within The Body The Presence And Importance Of Mental Health Within Traditional Tibetan Medicine, Reta Flynt

Independent Study Project (ISP) Collection

The purpose of this Independent Study Project was to identify aspects of mental health within the traditional Tibetan medical system that are both taught in the classroom and carried out in clinical practice, with a primary focus on the importance of maintaining mental health. Throughout the research process, aspects of illness etiology, diagnosis, treatment processes, and influence from Tibetan Buddhism were found to be deeply connected in maintaining mental health within patients of Traditional Tibetan medicine. As well, much emphasis was found on the mind's influence on the physical wellbeing of an individual, suggesting that mental and physical health are …

The Impact Of Vaccine Hesitancy On The Polio Vaccine In South Asia, Leah Everist

Independent Study Project (ISP) Collection

A disease that paralyzes hundreds of children each year, polio is incurable but also entirely preventable through vaccination. Though part of the reason some children are not reached for immunization is that they are in areas too volatile for healthcare workers to access, vaccine hesitancy is increasingly being recognized as an important player. The objective of this study is to ascertain the degree to which vaccine hesitancy affects polio vaccine campaigns in Afghanistan and Pakistan, the countries in South Asia where polio continues to be endemic, to assess the drivers behind hesitancy in this region, and to present recommendations for …