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Ageing, Chronic Alcohol Consumption And Folate Are Determinants Of Genomic Dna Methylation, P16 Promoter Methylation And The Expression Of P16 In The Mouse Colon, Julia Sauer, Hyeran Jang, Ella M. Zimmerly, Kyong-Chol Kim, Zhenhua Liu, Aurelie Chanson, Donald E. Smith, Joel B. Mason, Simonetta Friso, Sang-Woon Choi
Ageing, Chronic Alcohol Consumption And Folate Are Determinants Of Genomic Dna Methylation, P16 Promoter Methylation And The Expression Of P16 In The Mouse Colon, Julia Sauer, Hyeran Jang, Ella M. Zimmerly, Kyong-Chol Kim, Zhenhua Liu, Aurelie Chanson, Donald E. Smith, Joel B. Mason, Simonetta Friso, Sang-Woon Choi
Zhenhua Liu
Older age, dietary folate and chronic alcohol consumption are important risk factors for the development of colon cancer. The present study examined the effects of ageing, folate and alcohol on genomic and p16-specific DNA methylation, and p16 expression in the murine colon. Old (aged 18 months; n 70) and young (aged 4 months; n 70) male C57BL/6 mice were pair-fed either a Lieber-DeCarli liquid diet with alcohol (18 % of energy), a Lieber-DeCarli diet with alcohol (18 %) and reduced folate (0·25 mg folate/l) or an isoenergetic control diet (0·5 mg folate/l) for 5 or 10 weeks. Genomic DNA methylation, …