Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 7 of 7
Full-Text Articles in Medicine and Health Sciences
Hepatocellular Damage Following Amphetamine Intoxication, Alison Jones, D Jarvie, G Mcdermid, A Proudfoot
Hepatocellular Damage Following Amphetamine Intoxication, Alison Jones, D Jarvie, G Mcdermid, A Proudfoot
Alison L Jones
We report two cases of hepatocellular damage after ingestion of amphetamine in one case and both amphetamine and methylenedioxyamphetamine in another case, and postulate possible mechanisms responsible for this.
Cognitive Skills Underlying Driving In Patients Discharged Following Self-Poisoning With Central Nervous System Depressant Drugs, Tharaka Dassanayake, Patricia Michie, Alison Jones, Trevor Mallard, Ian Whyte, Gregory Carter
Cognitive Skills Underlying Driving In Patients Discharged Following Self-Poisoning With Central Nervous System Depressant Drugs, Tharaka Dassanayake, Patricia Michie, Alison Jones, Trevor Mallard, Ian Whyte, Gregory Carter
Alison L Jones
Background: Central nervous system–depressant (CNS-Ds) drugs can impair cognitive functions and driving. They are also the most common drugs taken in overdose in hospital-treated episodes of self-poisoning. In Australia most of these patients are discharged within 48 h, while they still have possible subclinical drug effects. We aimed to determine whether patients treated for self-poisoning with CNS-Ds are impaired in the Trail-Making Test (TMT, parts A and B), a neuropsychological test that is known to correlate with driving performance. Methods: This study was a conducted from November 2008 to April 2011 in a referral center for poisonings in New South …
Plasma Salicylate Concentrations Following Overdose; Are They Worth It ?, David Muir Wood, Alison Jones, Paul Dargan
Plasma Salicylate Concentrations Following Overdose; Are They Worth It ?, David Muir Wood, Alison Jones, Paul Dargan
Alison L Jones
Treatment following salicylate ingestion is determined by clinical evidence of toxicity. Previous studies have shown that routine measurement of plasma salicylate concentrations in all overdose patients is unnecessary except in those with clinical features suggestive of salicylate poisoning or in those who are unable to give an accurate history [1]. This retrospective study evaluates whether plasma salicylate concentrations are appropriately measured. A retrospective study of all plasma salicylate concentrations measured in St Thomas’ Hospital Accident and Emergency department from 1 February 2001 to 31 January 2002 was conducted. Admission record cards were surveyed for history of salicylate ingestion, clinical features …
Risk Of Road Traffic Accidents In Patients Discharged Following Treatment For Psychotropic Drug Overdose: A Self-Controlled Case Series Study In Australia, Tharaka L. Dassanayake, Alison L. Jones, Patricia Michie, Gregory Carter, Patrick Mcelduff, Barrie J. Stokes, Ian Whyte
Risk Of Road Traffic Accidents In Patients Discharged Following Treatment For Psychotropic Drug Overdose: A Self-Controlled Case Series Study In Australia, Tharaka L. Dassanayake, Alison L. Jones, Patricia Michie, Gregory Carter, Patrick Mcelduff, Barrie J. Stokes, Ian Whyte
Alison L Jones
Background: Use of psychotropic drugs is known to impair driving and increase the risk of road traffic accidents. They are also the most common drugs taken in overdose in hospital-treated episodes of self-poisoning. Most patients who take psychotropic drug overdoses are discharged within 48 hours, while they still have possible subclinical drug effects. Objective: Using a self-controlled case series design, we aimed to determine whether patients with psychotropic drug overdose are at a higher risk of a traffic accident in the period following discharge compared with a control period not associated with hospital-treated drug overdose. Methodology: Using the New South …
Hepatocellular Damage Following Therapeutic Intravenous Iron Sucrose Infusion In A Child, David Wood, Alison Thomson, Matthew Lawes, Alison Jones, Paul Dargan
Hepatocellular Damage Following Therapeutic Intravenous Iron Sucrose Infusion In A Child, David Wood, Alison Thomson, Matthew Lawes, Alison Jones, Paul Dargan
Alison L Jones
The maximum tolerated single dose of intravenous iron infusion and iron pharmacokinetics are not known in children and not clear in adults. The case reported here is of a child given a large dose of intravenous iron sucrose (16 mg/kg) over 3 hours, who subsequently developed features of systemic iron toxicity. A TDM consultant discusses the case in the context of toxicokinetic analysis. Because the maximum tolerated dose and pharmacokinetics of intravenous iron preparations are not known, their use in both adults and children should still be undertaken with caution.
Severe Hypokalaemic Metabolic Alkalosis Following Ingestion Of Gaviscon, I Gawarammana, J Coburn, S Greene, Paul Dargan, Alison Jones
Severe Hypokalaemic Metabolic Alkalosis Following Ingestion Of Gaviscon, I Gawarammana, J Coburn, S Greene, Paul Dargan, Alison Jones
Alison L Jones
Uncommon metabolic abnormalities in the emergency department could be a result of drug overdose due to uncommon agents. Case report. A 35-year-old male presented to the emergency department with a Glasgow Coma Scale (GCS) of 3/15 and a normal pulse rate and blood pressure. Subsequent questioning after recovery revealed he had ingested 2 L of Gaviscon® over the preceding 48 hours. He had normal haematology, liver, and renal function during admission. The electrocardiogram showed T wave inversion in the inferior leads on admission. Arterial blood gas on air was: pH 7.54, HCO3 50 mmol/L (50 meq/L), Chloride 66 mmol/L, anion …
Status Epilepticus Following Intentional Overdose Of Fluvoxamine: A Case Report With Serum Fluvoxamine Concentration, David Wood, Yadhunanthanan Rajalingam, S Greene, Phillip E. Morgan, David Gerrie, Alison Jones, Paul Dargan
Status Epilepticus Following Intentional Overdose Of Fluvoxamine: A Case Report With Serum Fluvoxamine Concentration, David Wood, Yadhunanthanan Rajalingam, S Greene, Phillip E. Morgan, David Gerrie, Alison Jones, Paul Dargan
Alison L Jones
Fluvoxamine is a selective serotonin reuptake inhibitor (SSRI) that is used in the management of depression and obsessive compulsive disorders. We report a patient with status epilepticus requiring quadruple anti-convulsant treatment following a fluvoxamine overdose. Case Report. A 25-year-old female presented with drowsiness at 12 hours following deliberate ingestion of 9.6 grams of fluvoxamine. Sixteen hours after ingestion, she developed status epilepticus that required treatment with benzodiazepines (lorazepam and midazolam), thiopentone, phenytoin and phenobarbitone. Her serum fluvoxamine concentration on presentation was 1970 μg/L (therapeutic 160–220 μg/L) and routine toxicological screening was negative for other drugs. She was discharged home after …