Open Access. Powered by Scholars. Published by Universities.®
- File Type
Articles 1 - 6 of 6
Full-Text Articles in Medicine and Health Sciences
Is Cocaine Use Recognised As A Risk Factor For Acute Coronary Syndrome By Doctors In The Uk?, David Wood, Duncan Hill, Awini Gunasekera, S Greene, Alison Jones, Paul Dargan
Is Cocaine Use Recognised As A Risk Factor For Acute Coronary Syndrome By Doctors In The Uk?, David Wood, Duncan Hill, Awini Gunasekera, S Greene, Alison Jones, Paul Dargan
Alison L Jones
Background: Cocaine is a sympathomimetic agent that can cause coronary artery vasospasm leading to myocardial ischaemia, acute coronary syndrome and acute myocardial infarction (ACS/AMI). The management of cocaine-induced ACS/AMI is different to classical atheromatous ACS/MI, because the mechanisms are different. Methods: Knowledge study—Junior medical staff were given a scenario of a patient with ACS and asked to identify potential risk factors for ACS and which ones they routinely asked about in clinical practice. Retrospective study—Retrospective notes reviews of patients with suspected and proven (elevated troponin T concentration) ACS were undertaken to determine the recording of cocaine use/non-use in clinical notes. …
Portal And Systemic Haemodynamic Response To Acute And Chronic Administration Of Low And High Dose Isosorbide-5-Mononitrate In Patients With Cirrhosis, Alison Jones, I Bangash, James Walker, K Simpson, N Finlayson, P Hayes
Portal And Systemic Haemodynamic Response To Acute And Chronic Administration Of Low And High Dose Isosorbide-5-Mononitrate In Patients With Cirrhosis, Alison Jones, I Bangash, James Walker, K Simpson, N Finlayson, P Hayes
Alison L Jones
Oral isosorbide-5-mononitrate (Is-5-Mn) was given in doses of 10 and 40 mg acutely and chronically (twice daily for four weeks), allowing a nitrate free interval to 25 patients with cirrhosis. Both 10 mg and 40 mg Is-S-Mn reduced the hepatic venous pressure gradient acutely and chronically, without evidence of tolerance. This was achieved by a reduction in the wedged hepatic venous pressure. The effect on mean azygos blood flow was variable with no significant mean change seen acutely or after chronic use with either dose. The variability was dependent not on the dose used but on the initial azygos flow; …
An Evidence Based Flowchart To Guide The Management Of Acute Salicylate (Aspirin) Overdose, Paul Dargan, Craig Wallace, Alison Jones
An Evidence Based Flowchart To Guide The Management Of Acute Salicylate (Aspirin) Overdose, Paul Dargan, Craig Wallace, Alison Jones
Alison L Jones
Objective: To develop a flowchart to be used as a tool to guide clinicians step by step through the management of salicylate poisoning. Methods: A comprehensive literature search was carried out. Results: The evidence base was used to develop a management flowchart that guides the clinician through the three main steps in caring for the patient with salicylate poisoning: preventing further absorption, assessing the severity of poisoning and, where appropriate, increasing elimination. Conclusions: Salicylate poisoning can result in severe morbidity and mortality and this flowchart provides an evidence based guideline that will guide clinicians through the management of patients presenting …
Acute Poisoning: Understanding 90% Of Cases In A Nutshell, S Greene, Paul Dargan, Alison Jones
Acute Poisoning: Understanding 90% Of Cases In A Nutshell, S Greene, Paul Dargan, Alison Jones
Alison L Jones
The acutely poisoned patient remains a common problem facing doctors working in acute medicine in the United Kingdom and worldwide. This review examines the initial management of the acutely poisoned patient. Aspects of general management are reviewed including immediate interventions, investigations, gastrointestinal decontamination techniques, use of antidotes, methods to increase poison elimination, and psychological assessment. More common and serious poisonings caused by paracetamol, salicylates, opioids, tricyclic antidepressants, selective serotonin reuptake inhibitors, benzodiazepines, non-steroidal anti-inflammatory drugs, and cocaine are discussed in detail. Specific aspects of common paediatric poisonings are reviewed.
Prolonged N-Acetylcysteine Therapy In Late Acetaminophen Poisoning Associated With Acute Liver Failure--A Need To Be More Cautious?, T Nimmi, C Athuraliya, Alison Jones
Prolonged N-Acetylcysteine Therapy In Late Acetaminophen Poisoning Associated With Acute Liver Failure--A Need To Be More Cautious?, T Nimmi, C Athuraliya, Alison Jones
Alison L Jones
Since the 1970s, N-acetylcysteine (NAC) has shown proven efficacy as an antidote for acetaminophen (APAP) poisoning and APAP-induced liver failure for early presenters. The current evidence of benefits of NAC for late presenters is controversial because of the poor understanding of the mechanism of late toxicity. In the previous issue of Critical Care, Yang and colleagues use a mouse model to demonstrate that NAC in doses similar to those used therapeutically to treat APAP poisoning in humans impairs liver regenerative capacity and that the effect is more pronounced when administered for a longer duration. Studies based on cell cultures support …
Use Of An Ivc Filter In The Management Of Ivc Thrombosis Occurring As A Complication Of Acute Pancreatitis, Alison Jones, D Ojar, D Redhead, A Proudfoot
Use Of An Ivc Filter In The Management Of Ivc Thrombosis Occurring As A Complication Of Acute Pancreatitis, Alison Jones, D Ojar, D Redhead, A Proudfoot
Alison L Jones
Vascular thrombosis and hypercoagulable states complicating pancreatitis are thought to be due to release of proteolytic enzymes from the pancreas and direct vasculitis. Inferior vena cava (IVC) thrombosis is an extremely rare complication o f chronic [1] and acute [2,3] pancreatitis.