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Full-Text Articles in Medicine and Health Sciences
Hormones And Endocrine-Disrupting Chemicals: Low-Dose Effects And Nonmonotonic Dose Responses, Laura Vandenberg, Theo Colborn, Tyrone Hayes, Jerrold Heindel, David Jacobs Jr., Duk-Hee Lee, Toshi Shioda, Ana Soto, Frederick Vom Saal, Wade Welshons, R. Zoeller, John Myers
Hormones And Endocrine-Disrupting Chemicals: Low-Dose Effects And Nonmonotonic Dose Responses, Laura Vandenberg, Theo Colborn, Tyrone Hayes, Jerrold Heindel, David Jacobs Jr., Duk-Hee Lee, Toshi Shioda, Ana Soto, Frederick Vom Saal, Wade Welshons, R. Zoeller, John Myers
Laura Vandenberg
For decades, studies of endocrine-disrupting chemicals (EDCs) have challenged traditional concepts in toxicology, in particular the dogma of “the dose makes the poison,” because EDCs can have effects at low doses that are not predicted by effects at higher doses. Here, we review two major concepts in EDC studies: low dose and nonmonotonicity. Low-dose effects were defined by the National Toxicology Program as those that occur in the range of human exposures or effects observed at doses below those used for traditional toxicological studies. We review the mechanistic data for low-dose effects and use a weight-of-evidence approach to analyze five …
Exposure To Bisphenol A In Canada: Invoking The Precautionary Principle, Laura Vandenberg
Exposure To Bisphenol A In Canada: Invoking The Precautionary Principle, Laura Vandenberg
Laura Vandenberg
No abstract provided.
Biomonitoring Studies Should Be Used By Regulatory Agencies To Assess Human Exposure Levels And Safety Of Bisphenol A, Laura Vandenberg, Ibrahim Chahoud, Vasantha Padmanabhan, Francisco Paumgartten, Gilbert Schoenfelder
Biomonitoring Studies Should Be Used By Regulatory Agencies To Assess Human Exposure Levels And Safety Of Bisphenol A, Laura Vandenberg, Ibrahim Chahoud, Vasantha Padmanabhan, Francisco Paumgartten, Gilbert Schoenfelder
Laura Vandenberg
BACKGROUND: Within the past 3 years, four major evaluations of bisphenol A (BPA) safety have been undertaken. However, these assessments have arrived at quite different conclusions regarding the safety of BPA at current human exposure levels. OBJECTIVES: We compared the reasons provided by the European Food Safety Authority (EFSA) BPA risk assessment panel for their conclusion that human exposures are negligible with the conclusions reached by the other panels, with all panels having the same body of literature at their disposal. DISCUSSION: The EFSA panel dismissed > or = 80 biomonitoring studies that documented significant levels of BPA exposure in humans, …