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Global Gene Expression Analysis In The Livers Of Rat Offspring Perinatally Exposed To Low Doses Of 2,2',4,4’-Tetrabromodiphenyl Ether, Alexander Suvorov, Larissa Takser
Global Gene Expression Analysis In The Livers Of Rat Offspring Perinatally Exposed To Low Doses Of 2,2',4,4’-Tetrabromodiphenyl Ether, Alexander Suvorov, Larissa Takser
Alexander Suvorov
BACKGROUND: Polybrominated diphenyl ethers are a group of flame-retardant chemicals appearing increasingly in the environment. Their health effects and mechanisms of toxicity are poorly understood.
OBJECTIVES: We screened for the sensitive effects and mechanisms of toxicity of 2,2 ,4,4 -tetra-bromodiphenyl ether (BDE-47) by analyzing the gene expression profile in rats exposed to doses comparable to human exposure.
METHODS: Wistar dams were exposed to vehicle or BDE-47 (0.002 and 0.2 mg/kg body weight) every fifth day from gestation day 15 to postnatal day 20 by injections to caudal vein. Total RNA was extracted from the livers of pups and hybridized to …