Medicine and Health Sciences Commons^™

Spatial Autocorrelation Of Tuberculosis Cases In Central Java Province In 2022, Izzatul Mardiah Saini, Tris Eryando

Jurnal Biostatistik, Kependudukan, dan Informatika Kesehatan

Tuberculosis still becomes a health problem both in the world and in Indonesia. Central Java is The third highest province of tuberculosis in Indonesia. Spatial analysis is an essential tool for evaluating the tuberculosis distribution pattern according to geographic location. This research aims to determine tuberculosis hotspot areas and discover whether there is a spatial correlation between districts/cities in Central Java based on tuberculosis cases using the spatial autocorrelation method through the Moran Index and Local Indicators of Spatial Associations (LISA). Secondary data in the form of the aggregate number of all tuberculosis cases in 2022 was collected from the …

Data Mining Analysis With Orange In The Development Of Tuberculosis Among Diabetes Mellitus Patients, Malahayati Rusli Bintang, Adang Bachtiar, Cicilya Candi

Kesmas

Prevention and treatment of diabetes will have a positive influence on tuberculosis (TB) since people may get TB because they have diabetes mellitus (DM). Recording and reporting through the TB Information System are not run optimally because of many factors. The information system must be strengthened to be used by private health facilities. This study used secondary data from the 2013 and 2018 Indonesian Basic Health Research (IBHR). The data was analyzed univariately and analyzed further using Orange Data Mining Tools to test the screening tool model used to predict TB in diabetic individuals. The total sample in this study …

Assessment Of Mycobacterium Tuberculosis Drug-Resistance Patterns In A Public Hospital Of Lima, Peru During 2022, Jorge Roberto Mosqueira Sanchez, María Angélica Paredes Moreno, Julio César Layseca Ortiz, Nancy Victoria Mogrovejo Olivera, Alvaro Oyarce Calderón

Revista de la Facultad de Medicina Humana

Background. Tuberculosis is a public health problem considered to be the world's leading cause of death from an infectious disease among adults. Diagnosis is often challenging and is based on clinical, epidemiological, radiological, bacteriological, histological and biochemical findings. Timely diagnosis, identification of the susceptibility profile and follow-up compliance is important to enable more effective treatment and avoid severe forms of the disease. Aim. Describe the resistance patterns of Mycobacterium tuberculosis identified in the period of the year 2022 at Hospital María Auxiliadora. Material and Methods. This is an observational, cross-sectional study of patients diagnosed with tuberculosis throughout the year 2022 …

Development Of An Evidence-Based Tool To Assess The Relative Vulnerability Of Different Communities To Tuberculosis, Slamet Isworo, Sri Handayani, Reece Hinchcliff, Zainal Arifin Hasibuan

Kesmas

Identifying specific tuberculosis (TB) vulnerabilities in populations based on their geographical, demographic, and epidemiological characteristics is anessential yet challenging requirement to help reduce and eliminate TB. Assessment tools that can accurately quantify the risks associated with key factorscould be used to measure TB vulnerability efficiently and indicate the most appropriate range of interventions. This study aimed to develop TB vulnerability assessment tools based on a TB vulnerability assessment conceptual framework developed with Leximancer. Three steps to produce the tools were facetanalysis, interpreting the facet to create a list of questions, and expert judgment to confirm the suitability of the questionnaire. …

Metabolomic Insights Into Tuberculosis: Machine Learning Approaches For Biomarker Identification, Miftahul Khair Akbar, Arief Aulia Rahman

Indonesian Journal of Medical Chemistry and Bioinformatics

The lung parenchyma is largely impacted by the infectious condition known as pulmonary tuberculosis (pulmonary TB) when the immune system creates a wall around the germs in the lungs, a tiny, hard bulge known as a tubercle develops, earning the disease the name tuberculosis. Although the majority of TB germs target the lungs, they can also harm other bodily organs. The identification of TB biomarkers, which are crucial for diagnosis, treatment monitoring, risk analysis, and prognosis, has been the subject of extensive research. Differences in metabolites between normal cells and tuberculosis are considered to be able to support the diagnosis …

Spatial Analysis Of The Influence Of Residential Density On The Spread Of Tuberculosis Cases In Pasar Rebo General Hospital Service Area, Andi Efendi, Teungku Ichramsyah Darwis

Cities and Urban Development Journal

Background: Based on statistical data, in 2021 tuberculosis cases in the DKI Jakarta area reached 26,854, an increase of around 21% from 2020, 22,156 cases.

Aims: This Study focuses on the lavel of administrative area whether a residential density shows significance in the spread of Pulmonary Turberculosis (TB) cases.

Methods: The research carried out by a descriptive quantitative research in the Pasar Rebo General Hospital.

Results: The distribution of patients in the Pasar Rebo General Hospital is not affected by the total population density found in a sub-district area. After the research was carried out in a smaller administrative scope, …

Utilizing Rapid Molecular Tests (Rmt/Rif) In Tuberculosis Drug-Sensitive/Resistant Discovery In Indonesia: A Pilot Study, Maria Holly Herawati, Dasuki Dasuki, Dina Bisara Lolong, Mirna Widiyanti, Betty Roosihermiatie, Ria Yuda Permata, Raflizar Raflizar, Ferry Ahmadi, Hadi Supratikta, Meita Veruswati

Kesmas

The underdiagnosis and underreporting of tuberculosis (TB) indicators are unresolved problems. The rapid molecular test (RMT) is one of the breakthroughs for TB case finding by using safer and more sensitive equipment; it is even believed to help find drug-resistant TB. The results of several webinars held regularly by a TB program as well as its evaluation and the use of RMT formed the basis of this study. This initial pilot study aimed to provide an overview of case finding for both drug-sensitive and drug-resistant TB using RMT. A cross-sectional study was conducted on samples in several provinces in Indonesia …

Dare To Differ - A Doctor’S Quest For A Gentle Cure, Renu Mittal

Indian Journal of Research in Homoeopathy

Dare to Differ- A Doctor's Quest for a Gentle Cure

Secondary Spontaneous Tension Pneumothorax: A Case Report Of An Uncommon Presentation Of Post-Tuberculosis Sequelae, Herick Alvenus Willim

The New Ropanasuri Journal of Surgery

Introduction. Tuberculosis (TB) remains one of the top life-threatening infectious diseases worldwide. Even after completion of treatment, numerous patients had post-TB sequelae as a consequence of lung damage during TB infection. We reported an uncommon case of secondary spontaneous tension pneumothorax in a patient with post-TB sequelae.

Case Presentation. A 68-year-old smoker man presented with sudden shortness of breath since 2 hours ago. He had a history of pulmonary TB 15 years ago which had completed antituberculosis treatment and had been experiencing symptoms associated with post-TB sequelae for the last 1 year. Physical examinations and chest X-ray showed tension pneumothorax. …

Sacral Tuberculosis Masquerading As Meningocele, Devanand Senthil Kumar S., Anbazghan Periyasamy, Shayee Kalyee Shanjeev, Raj Gowtham Rajgowtham

Advanced Spine Journal

Background Data: Spine is the most common site of extrapulmonary tuberculosis. Among the various spine segments, isolated involvement of the sacrum is the rarest presentation. A high index of suspicion is needed to diagnose and treat it.

Purpose: We present the findings of a presacral cystic lesion found to be tubercular because of its unusual presentation explaining the diagnostic difficulty, management, and outcomes.

Study Design: This is a case report and literature review.

Patients and Methods: We report a 12-year-old female child presenting with low back ache radiating to both thighs, difficulty in ambulation, and swelling in the right gluteal …

Is It Tuberculosis Mastitis Or Granulomatous Mastitis? A Thirteen-Year Experience At A University Hospital, Handan İnönü Köseoğlu, Mehmet Fati̇h Daşiran, Reşi̇t Doğan Köseoğlu, Zeki̇ye Ruken Yüksekkaya Çeli̇kyay, Mehmet Berati̇ Kaleli̇oğlu

Turkish Journal of Medical Sciences

Background/aim: Granulomatous mastitis (GM) is a rare inflammatory disease of the breast. Tuberculosis mastitis (TM), one of the causes of GM, is a rare form of extrapulmonary tuberculosis. The clinical, radiological, and histopathological findings of TM and GM are similar, and sometimes it is difficult to make a distinction between these disease states. In this study, we aimed to evaluate the clinical and radiological features, diagnostic techniques, treatment modalities and treatment outcomes of the patients with GM and TM. Materials and methods: The data of the patients with confirmed GM by histopathologic examination of biopsy specimens between 2007 and 2020 …

Evaluation Of Treatment Regimens And Long-Term Clinical Outcomes In Patients With Isoniazid-Resistant Pulmonary Tuberculosis: A 5-Year Follow-Up, Ayşe Feyza Aslan, Medi̇ha Gönenç Ortaköylü, Belma Akbaba Bağci, Sezer Toprak

Turkish Journal of Medical Sciences

Background/aim: Considering its early bactericidal activity, isoniazid (H) is an important first-line agent in tuberculosis (TB) treatment. The aim of this study was to evaluate the treatment regimens and results of H-resistant pulmonary TB patients. Materials and methods: We retrospectively evaluated treatment regimens and results of 188 H-resistant pulmonary TB patients who were treated in our center between January 2015 and December 2017. Treatment regimens applied were noted and treatment outcomes were recorded. The long-term results were evaluated. Results: Totally 174 (92.6%) of 188 patients with H-resistant pulmonary TB achieved treatment success. Ninety-seven patients (51.6%) were cured and 77 patients …

Case Series; Imaging In Lesser-Known Ailments Of The Pituitary Gland And Sellar Region, Harisha H L, Kavya Bhadrapura Thimmegowda, Ajay Hanumanthu, Vikram Patil Dr, Gurumurthy B, Dr Abhijith Roys

Digital Journal of Clinical Medicine

No abstract provided.

Cutaneous Adverse Drug Reaction Among Hiv-Infected Patients Starting Antituberculosis Treatment, Alvina Widhani, Teguh Harjono Karjadi, Evy Yunihastuti, Desi Salwani, Angga Pramudita, Saut Horas Nababan, Mirna Nurasri Praptini, Prionggo Mondrowinduro

Jurnal Penyakit Dalam Indonesia

Introduction. Treatment of tuberculosis (TB) in HIV patients is complicated due to numerous comorbidities and possible adverse effects. One of which is cutaneous adverse drug reaction (CADR). This adverse event is often difficult to manage because of multiple medications the patients get. The objective of this study was to know the prevalence and risk factors of CADR among HIV-infected patients starting anti-TB treatment. Methods. This retrospective study reviewed data from medical records of new patients at Working Group on AIDS outpatient clinic at Cipto Mangunkusumo Hospital, Indonesia in January 2008-December 2010 that had started anti-TB treatment. Risk factors of CADR …

Impact Of Instrumental Support From Family On Medication Adherence Among Tuberculosis Patients, Astuti Yuni Nursasi, Mega Hasanul Huda, Syifa Widya Rahmasari

Kesmas

Instrumental support is concrete and tangible, for instance, helping to provide food or accompanying patients to health care facilities. However, its impact on medication adherence among tuberculosis patients in Indonesia needs to be explored. This study aimed to examine the impact of instrumental support from family on tuberculosis patients’ adherence to medication in Bogor City, West Java Province, Indonesia. A cross-sectional study involving 106 participants with an age average of 39.7 (SD = 14.9) was conducted in 12 primary health care (PHC). The independent variables (age, sex, education, employment status, wealth index, and the distance between home and PHC) of …

Tuberculoso Orchiepididymitus In Insulinodependent Type 2 Diabetes Mellitus: Case Report, Gonzalo Carrillo-Sanabria, Brayan Dávila-Aranda, Rodolfo Cairo-Huaringa, Richard Maita-Hinostroza, Jorge Chumbes-Pérez

Revista de la Facultad de Medicina Humana

Introduction: There is little information in Peru on the association of tuberculous orchiepididymitis in relation to immunosuppressed patients, being an endemic country of tuberculosis and there is an increase in the prevalence of chronic noncommunicable diseases such as diabetes, producing wrong diagnoses. Clinical Case: We present the case of a 70-year-old man with a history of type 2 diabetes mellitus who was admitted to the outpatient clinic due to dysuria and frequency. On physical examination, a hard, non-painful right testicle, the ultrasound showed signs of epididymal abscess in the scrotal wall of the Right testicle, which is why an infected …

A Vanishing Cardiac Mass, Moayad M. Alqurashi, Ahmed Alsaileek, Thamer H. Alenazi, Basel M. Alhaijani, Ahmed Aljizeeri

Journal of the Saudi Heart Association

The prevalence of extrapulmonary tuberculosis (TB) is very common in the Middle East; however, myocardial involvement is among the most infrequent manifestations of extrapulmonary TB. We present an asymptomatic young adult who was incidentally found to have a large right atrial tuberculoma, diagnosed by non-invasive cardiac imaging and effectively treated with standard first-line anti-TB treatment, steroids, and anticoagulation. This case is a classical presentation of nodular myocardial involvement of TB, highlighting advantages of advanced imaging, e.g., cardiac magnetic resonance (CMR) and multidisciplinary treatment.

Incidence Of Tuberculosis In The Association Of South-East Asia Nation (Asean) Countries And Its Relation With Health Expenditure: A Secondary Data Analysis., Vaanita Shanmuham, Jeevan K. Shetty, Venkatesh Ramaswamy Naik

Manipal Journal of Nursing and Health Sciences

Introduction: Tuberculosis (TB) is an infectious disease that mainly affects the lungs. ASEAN is responsible for the high incidence of tuberculosis recorded worldwide. Therefore, this study analyses the trend of tuberculosis and its association with per capita health expenditure in ASEAN.

Methods: The incidence of tuberculosis and the per capita health expenditure are collected from Global Health Observatory resources and World Bank Organization. The data were interpreted using SPSS Software Version 23 and the results were presented in graphs and tables.

Results: Six ASEAN countries showed a declining trend, three countries had a fluctuating trend, and one country had an …

Analysis Of The Relationship Between Tuberculosis-Related Mortality And Nitrous Oxide Emission Levels In The World With The Environmental Kuznets Curve Method, Şeri̇fe Torun, Kadi̇r Yilmaz, Şevket Özkaya, Şebnem Yosunkaya, Müşerref Şule Akçay

Turkish Journal of Medical Sciences

Background/aim: It was aimed to analyze the relationship between tuberculosis-related mortality and nitrous oxide emission levels in the world with the Environmental Kuznets Curve (EKC) Method. Materials and methods: WHO ICD-10 mortality list data and the World Bank Country Data (WBCD) were used between 1997 and 2017 for 12 countries. Cubic regression analysis was used for EKC Analysis. Results: The difference between male and female deaths between 1996 and 1998 has increased sharply since 1999. Male deaths consistently occurred significantly more than female deaths. There was a significant and negative correlation between Nitrous oxide emissions (% change from 1990) and …

Retropharyngeal Abscess And Pott’S Disease Due To Tuberculosis: A Case Report, Bailey N. Hassman, Steven D. Curry, Jonathan H. Ryder, Angela L. Hewlett, Jayme R. Dowdall

Graduate Medical Education Research Journal

Introduction: Extrapulmonary mycobacterial infection can lead to vertebral spondylitis and osteomyelitis (Pott’s disease). Retropharyngeal abscess with concurrent spinal osteomyelitis is a rare presentation of tuberculosis in the US. Chart review on a patient was completed, and the relevant published literature was reviewed.

Case Presentation: A previously healthy 34-year-old male originally from Sudan presented to an outside hospital with a 2-month history of neck pain, sore throat, odynophagia, fevers, and chills. MRI showed a retropharyngeal abscess and suspected cervical spine osteomyelitis. Acid-fast bacillus (AFB) smear was positive from a neck drain specimen, but sputum was negative. Chest imaging did not show …

Integrated Model Of A Family Approach And Local Support In Tuberculosis Case Finding Efforts In People With Hiv/Aids, Erni Astutik, Chatarina Umbul Wahyuni, Imelda F E Manurung, Geofrey Ssekalembe

Kesmas

The human immunodeficiency virus (HIV) remains a major global public health problem. People with HIV/acquired immune deficiency syndrome (AIDS) are more susceptible to opportunistic infections such as tuberculosis (TB). Therefore, families and community leaders need to help monitor people living with HIV/AIDS (PLWHA). This study aimed to analyze an integrated family approach and local support model to detect TB cases in PLWHA. This study used a case-control study in Kupang City, East Nusa Tenggara Province, in July 2020. The sample comprised 100 people (50 PLWHA with TB case and 50 controls) using total sampling and random sampling, respectively. The variables …

Strongyloides Stercoralis Hyperinfection And Disseminated Tuberculosis, Hernan Terroba, Alejandra González, Diana Vera Gonzalez, Roxana Mariela Godoy, Analia Santos, Marisol Arrojo

The University of Louisville Journal of Respiratory Infections

No abstract provided.

Cloning Of Pe11 (Lipx, Rv1169c) Gene Of Mycobacterium Tuberculosis Beijing Strain To Pcdna3.1 Plasmid Vector, Lulut Azmi Supardi, Andriansjah Rukmana, Fithriyah Sjatha

Makara Journal of Science

Tuberculosis (TB) is an infectious disease caused by Mycobacterium tuberculosis. It is a persistent global health problem with a high mortality rate. Currently, TB is controlled by administering the Bacillus Calmette-Guerin (BCG) vaccine, but the effectiveness of its protection varies among individuals in a population. The pe/ppe gene family comprises a typical group of genes that play a role in avoiding the host immune response and inducing persistent TB infection. Based on in silico analysis, the pe11 gene has estimated immunogenicity and potential as a TB seed vaccine candidate. The pe11 gene from an Indonesian isolate of an M. …

Risk Of Tuberculosis Is Increased In Behçet's Disease Compared To Other Rheumatologicaldisorders After Anti-Tnf∝ Treatments: A Case Series And Review Of The Literature, Ümmügülsüm Gazel, Derya Kocakaya, İrem Hi̇cret Topçu, Hakan Ömer Karataş, Murat Karabacak, Mehmet Pami̇r Atagündüz, Güzi̇de Nevsun İnanç, Fatma Ali̇baz Öner, Rafi̇ Haner Di̇reskeneli̇

Turkish Journal of Medical Sciences

Background/aim: Tumor necrosis factor-alfa (TNF-a) antagonists are extensively utilized in the treatment of inflammatory rheumatic diseases and also shown to be effective in Behçet's disease (BD) patients with major organ involvement. In this study, we aimed to reevaluate the incidence of tuberculosis (TB) infection after anti-TNFa treatments and to reveal the risk of TB in BD. Methods: Data of patients who received anti-TNFa treatment between 2005 and 2018 were assessed retrospectively. Demographic features, TNF-a antagonist type/treatment time, tuberculosis skin test (TST) and QuantiFERON results, isoniazid prophylaxis status, and concomitant corticosteroid (CS) treatments were collected. Results: A total of 1277 (male/female …

Cultural And Religious Belief Approaches Of A Tuberculosis Program For Hard-To-Reach Populations In Mentawai And Solok West Sumatera, Indonesia, Rizanda Machmud, Irvan Medison, Finny Fitry Yani

Kesmas

Tuberculosis (TB) is a leading public health concern in Indonesia. It ranks second on the list of high-burden TB countries. In West Sumatra, 47% of TB cases are undetected, late diagnosed, and received incomplete treatment because of low-level awareness and knowledge and stigma, especially among the hardest to reach populations. The study aims to identify the best communication channel to reach those who live in vulnerable and remote areas. This study was a qualitative study applying in-depth interviews to the informal leaders, health officers, cultural artists, and religious leaders across districts in Mentawai and Solok Districts, which are remote and …

Prevalence Of Tuberculosis In District Haveli, Azad Jammu And Kashmir, Abu Ul Hassan Faiz, Ghazal Tariq, Ayesha Faiz, Lariab Zahra Faiz

Journal of Bioresource Management

Tuberculosis is an infectious disease with a common occurrence in population of Azad Jammu and Kashmir. The current study was designed to find out the prevalence of TB among the general population of a less developed District Haveli. Samples were collected from different hospitals and TB centers located in district Haveli and tested through sputum smear microscopy for conformation of positive for TB. The three-year (2015 to 2018) study was conducted to record prevalence of tuberculosis in selected area of Azad Jammu and Kashmir. The trend line of prevalence was made by using (SPSS software). Results produced linear trends yearly …

Diagnóstico Tomográfico Tuberculosis Adrenal Y Addison - Altura, Amílcar Tinoco Solórzano, Brayan Dávila Aranda, Valeria Córdova Valenzuela, Gonzalo Carrillo Sanabria, Francisco Meza Legua

Revista de la Facultad de Medicina Humana

Reportamos el caso de un varón de 23 años, natural y residente de la altura, con hiperpigmentación. astenia, fatiga, náuseas, vómitos, pérdida de peso, dolor abdominal, hiporexia e hipotensión, con dosaje de cortisol disminuido y ACTH elevado. Radiografía de tórax normal, baciloscopia en esputo y en orina negativo. Antígeno TB LAM negativo. En la tomografía computarizada de abdomen con contraste se visualiza incremento de dimensiones y pequeñas calcificaciones en ambas adrenales sugerentes de infiltración granulomatosa de tipo específico. En zonas endémicas de tuberculosis como en el Perú, ante la ausencia de la biopsia adrenal, se puede recurrir en forma precoz, …

Tuberculosis Meníngea De Expresión Grave En Pediatría., Giuliana Reyes Florián, Martín Seminario Aliaga

Revista de la Facultad de Medicina Humana

La tuberculosis (TB) sigue siendo un problema de salud pública mundial. La magnitud real de esta epidemia está subestimada debido a las dificultades en el diagnóstico en niños y al escaso reporte. El diagnóstico de TB infantil representa un desafío, ya que en el niño la infección suele cursar con manifestaciones clínicas inespecíficas y muchas veces es asintomática, lo que retrasa el diagnóstico, conllevando a este grupo etario a un alto riesgo de infección diseminada. A continuación, describimos el caso de un niño preescolar con tuberculosis meníngea (TM), con presentación clínica subaguda de fiebre, trastorno de sensorio progresivo y signos …

Association Between The Adequacy Of Preoperative Antituberculosis Treatment With Abdominal Postoperative Morbidity And Mortality On Tuberculosis Patients, Riza El Anshori, Agi S. Putranto

The New Ropanasuri Journal of Surgery

Introduction. The adequacy of tuberculosis treatment before abdominal surgery is a dilemma faced by surgeons who aims for low risk of morbidity and mortality. In addition, there is no data on morbidity and mortality post abdominal operation on TB patients in RSCM and RS Persahabatan. Therefore, this research aims to show the correlation between the adequacy of preoperative TB treatment and postoperative morbidity (fistula enterocutaneous, obstruction, and surgical site infection) and mortality.

Method. This study is a descriptive-analytic cross-sectional study done in Cipto Mangunkusumo Hospital dan Persahabatan Hospital using total sampling method, a total of 59 subjects with …

Pulmonary Resection In Complicated Primary Pediatric Pulmonary Tuberculosis: An Evidence-Based Case Report, Hendra Wibowo, Suprayitno Wardoyo, Dhama Shinta

The New Ropanasuri Journal of Surgery

Introduction. Paediatric pulmonary tuberculosis incidence was increasing, with many undetected cases. Antituberculosis regiments are known to be the treatment of choice for tuberculosis. Even though pulmonary resection for pulmonary tuberculosis has reduced in daily practice, it remains continues to play an important role in several advanced conditions and complications. Currently, there are no specific practical guidelines concerning surgical indications and approaches for pulmonary tuberculosis. We report a case with complicated primary paediatric pulmonary tuberculosis underwent resection and looking for the literature of the best evidence.

Method. A case report completed with a discussion based on the best evidence. …