Medicine and Health Sciences Commons^™

Musculoskeletal Ultrasonography In Rheumatic Diseases, Erhan Çapkin

Turkish Journal of Medical Sciences

Ultrasonography is an imaging technique based on sound waves used for the evaluation of soft tissues. Sound waves have been used for a long time in nonmedical fields, including military defense systems, radar systems, and detection of icebergs. Technological advances resulted in new techniques becoming available for medical imaging, including ultrasonography, magnetic resonance imaging, and computed tomography. Nowadays, the use of imaging has become a gold standard protocol in the diagnosis of many diseases, and recently developed diagnosis and therapy options provide more efficient treatment of rheumatic diseases. Thus, it has become possible to prevent structural damage and disability in …

Craniocervical Junction Involvement In Inflammatory Arthritis: A Single-Center Radiologic Study, Fatma Yalçinkaya, Şafak Parlak Sağol, Aynur Azizova, Emre Bi̇lgi̇n, Kader Karli Oğuz, Umut Kalyoncu

Turkish Journal of Medical Sciences

Background/aim: Craniocervical junction (CCJ) can be involved in inflammatory arthritis. We aimed to define types of CCJ involvement in rheumatoid arthritis (RA), spondyloarthritis (SpA), and psoriatic arthritis (PsA) and compare them with patients without inflammatory arthritides. Materials and methods: In this retrospective analysis, cervical CT or MRIs of patients with RA, SpA, or PsA, taken for any reason between 2010 and 2020, according to ICD-10 codes, were scanned. Demographic data of the patients were recorded. CCJ involvements (atlantoaxial, vertical, or subaxial subluxation, odontoid process involvement) were reevaluated by an experienced radiologist. The control group consisted of consecutive patients without inflammatory …

Cd39 Expression On Immune Cells Predicts Methotrexate Response In Rheumatoid Arthritis Patients, Bariş Boral, İbrahi̇m Tuncer, Fi̇li̇z Ki̇bar, Sali̇h Çeti̇ner, Suade Özlem Badak, Emrah Salman, Emrah Koç, Eren Erken, Akgün Yaman

Turkish Journal of Medical Sciences

Background/aim: Rheumatoid arthritis (RA) is a chronic inflammatory disease affecting mostly small joints, such as hand and foot joints symmetrically with irreversible joint destruction. In this study, the relationship between CD39 expression and the treatment response of RA patients was examined to investigate its potential as a biomarker that demonstrates treatment response. Materials and methods: This study included 77 RA patients and 40 healthy controls (HC). The RA patients were divided into 2 groups based on their response to RA treatment, those with a good response to methotrexate (MTX) monotherapy and those with an inadequate response based on the American …

Body Mass Index Does Not Affect Response Of Rituximab In Patients With Rheumatoid Arthritis: Results From The Turkbi̇o Registry, Ahmet Karataş, Rabi̇a Pi̇şki̇n Sağir, Süleyman Serdar Koca, Hüseyi̇n Edi̇z Dalkiliç, Gerçek Can, Yavuz Pehli̇van, Ayten Yazici, Güzi̇de Nevsun İnanç, Ayşe Çefle, Zeynep Ertürk, Servet Akar, Soner Şenel, Ahmet Meri̇h Bi̇rli̇k, Nurullah Akkoç, Fatoş Önen

Turkish Journal of Medical Sciences

Background/aim: Adipose tissue produces several inflammatory mediators. Thus, obesity affects the disease course and the responses to the antirheumatic agents in inflammatory diseases. The aim of the study was to determine whether the body mass index (BMI) is involved in the response to rituximab in rheumatoid arthritis (RA). Materials and methods: This multicenter retrospective study included 206 RA patients who received rituximab from the Turkish Biologic (TURKBIO) registry between 2011 and the end of May 2017. Demographic and clinical data including age, sex, disease type, disease duration, and previous or current treatment with disease-modifying antirheumatic drugs (DMARDs) and biological drug …

Patient's Perspective Of Shared Decision-Making In Rheumatoid Arthritis Treatment: A Grounded Theory Exploration, Isabela Viana Oliveira, Mariana Martins Gonzaga Nascimento, Cristiane P. Rezende Mrs, Carina M. Neves, Hagabo Mathyell Silva, Ana Luiza Mourawad Cesar, Djenane Ramalho De Oliveira

The Qualitative Report

Current guidelines for rheumatoid arthritis (RA) treatment state that all decisions should be shared with the patient. Therefore, it becomes necessary to understand in-depth how patients with RA with different levels of health literacy and activation feel about sharing the decision with the health professional and how they experience this process. Grounded theory was used. Data collection included semi-structured interviews with 14 patients with RA. From the analysis of the patients’ narratives, four categories were built: “Accepting the changes: non-shared decisions”; “The patient's rationale: why not share?”; “Reaching the requirements for sharing the decision: expanding the patient’s autonomy"; and "Experiencing …

Pengaruh Terapi Metotreksat Pada Pasien Artritis Reumatoid Terhadap Penurunan Fungsi Kognitif: Meta-Analisis Berdasarkan Telaah Sistematik, Fara Fauzia, Nurhayati Adnan Prihartono, Rudy Hidayat, Abirianti P. Araminta

Jurnal Penyakit Dalam Indonesia

Introduction. Rheumatoid arthritis (RA) is a systemic and chronic autoimmune disease involving the joints disorder as the main manifestations. Methotrexate (MTX) is currently still the drug of choice for RA treatment due to the good clinical response. However, there was a case reported by the American Geriatric Society in 2015 regarding the presence of reversible dementia after treatment with low-dose oral methotrexate. This study aimed to identify the effect of MTX treatment on cognitive disorder in RA patients.

Methods. The study protocol was registered with PROSPERO (CRD42023414937). A systematic literature search was conducted in Medline Embase database, Scopus, CENTRAL …

Rheumatoid Vasculitis Presenting With Incidental Renal Infarcts: Case Report And Literature Review, Fatima Halilu, Howard Hauptman

Journal of Community Hospital Internal Medicine Perspectives

Rheumatoid vasculitis is a rare and late complication of rheumatoid arthritis, affecting small to medium sized vessels. Inflammation in the vessel wall produces an occlusive vasculopathy with downstream infarction. We present the case of a 70-year-old female with long standing stable RA status post recent COVID-19 vaccination admitted with community acquired Legionnaires disease found to have an incidental renal infarct on chest imaging without a clear etiology. She improved from a respiratory standpoint but then had a fever spike with repeat imaging showing a second renal infarct and CT angiography showing extensive beading with aneurysmal dilation in the bilateral hepatic …

A National, Multicenter, Retrospective Study Evaluating Retention Rate And Efficacy Of Tocilizumab Treatment In Patients With Active Rheumatoid Arthritis Who Had An Inadequate Response To Csdmards And/Or Tnf Inhibitors, Güzi̇de Nevsun İnanç, Mustafa Ender Terzi̇oğlu, Yusuf Karabulut, Zevcet Yilmaz, Emi̇ne Fi̇gen Tarhan, Mehmet Emi̇n Eneci̇k, Ali̇ Şahi̇n, Adem Küçük, Ayşe Ayan, Meti̇n Özgen, Uğur Karasu, Servet Yolbaş

Turkish Journal of Medical Sciences

Background/aim: To describe the disease activity and retention rate in rheumatoid arthritis (RA) patients with inadequate response (IR) to conventional synthetic disease-modifying antirheumatic drugs (csDMARDs) and/or tumor necrosis factor inhibitors (TNFis) who were prescribed tocilizumab (TCZ) as first-line or second-line biologic treatment in real-world setting. Materials and methods: Data gathered from patients' files was used in a multicenter and retrospective context. Retention rates and the Disease Activity Score in 28 joints with CRP (DAS28-CRP) were evaluated at time points. The relationship of drug efficacy with factors such as smoking, obesity, and previous use of TNFis was also examined. Results: One …

Dental And Oral Manifestations Of Rheumatoid Arthritis: Is It Related To General Disease Activity?, Omnia A. Abubakr, Ali M Youssef, Mohamed A Mohamed, Mohamed A Hamdy

Journal of Medicine in Scientific Research

Background: RA is a chronic immune-mediated systemic disorder; its pathogenesis is complex. Genetic, environmental, hormonal, and lifestyle are the main risk factors. The correlation between oral health and RA is rising. Oral manifestations in RA include temporomandibular joint disorder, secondary Sjögren’s syndrome, xerostomia, and periodontal disease. Previous studies suggest a bidirectional relationship between RA and periodontal diseases. This study aims to detect oral mucosal and dental disease in RA patients and its relation to demographic features, disease activity, and extra-articular manifestation. Patients and Methods: This cross-sectional study included 150 patients with RA allocated into two groups, 75 patients in each …

A Rheumatoid Nodule At The Sternoclavicular Joint: An Uncommon Presentation Of A Common Problem, Patrick M. Thomas, Nathan J. Cockerill, Christina M. Arcand, Alan R. Koester, Mark H. Cooper Md, Phd

Marshall Journal of Medicine

Most rheumatoid nodules are found at joints or pressure points. They rarely require medical intervention and even fewer require surgery. A 78-year-old female developed a 7.2 x 3.2 x 2.8 cm rheumatoid nodule originating at the right sternoclavicular joint, a novel site for a common pathology. Management involved a complex differential diagnosis and surgical treatment was resection from adjacent vascular and neural structures. Following surgical excision, the patient maintained good mobility and sensation of the neck and surrounding areas.

Effect Of Rheumatoid Arthritis Treatment On The Posterior Segment Of The Eye, Abdelkawy Moghazy, Ahmed S. Fayed, Heba A. R. Rizk, Moataz El-Sawy

Menoufia Medical Journal

Objective The aim of the study was to evaluate the influence of rheumatoid arthritis (RA) treatment on the posterior segment of the eye using spectral-domain optical coherence tomography. Background RA is a common chronic autoimmune systemic inflammatory disease that primarily affects mainly small joints. It may affect many parts of the eye, such as conjunctiva, cornea, sclera, uvea, choroid, and retina. Patients and methods The study included 44 RA patients (22 on methotrexate and 22 on etanercept), and 21 healthy controls. Results A significant increase in choroidal thickness in the RA group compared with the control group. There were no …

At-Home Aerobic Exercise Improves Functional Ability Of Patients With Rheumatoid Arthritis With Limited Exercise Options, Daniel Harris

Clinical Research in Practice: The Journal of Team Hippocrates

A clinical decision report using

Neuberger GB, Aaronson LS, Gajewski B, et al. Predictors of exercise and effects of exercise on symptoms, function, aerobic fitness, and disease outcomes of rheumatoid arthritis. Arthritis Rheum. 2007;57(6):943-952. https://doi.org/10.1002/art.22903

and its application for a patient with rheumatoid arthritis.

Quality Of Life, Duration Of The Disease And The Level Of Pain In Patients With Rheumatoid Arthritis, Ewa Kupcewicz, Agnieszka Drejer

Baltic Journal of Health and Physical Activity

The aim of the present study is to evaluate life quality of people suffering from RA and determine the influence of illness duration and degree of pain intensity on their quality of life. The group of subjects comprised of 189 people: 104 (55.03%) with diagnosed RA and 85 (44.97%) healthy people as control group. Mean age in the group of ill subjects was 57.66 ±11.30 and 68 ±8.99 in the control group. In the research, self-constructed questionnaire, Visual Analogue Scale (VAS) and shortened version of WHOQoL-Bref were used. Assumed significance level was p < 0.05. Patients with RA received statistically significantly lower scores of life quality in all domains as compared with the control group. In the group of ill subjects, social domain (14.91 ±2.40) obtained highest scores whereas physical domain received lowest scores (11.96 ±1.69). The main somatic issue connected with the illness reported by 95.19% of subjects was experienced joint pain. Mean degree of perceived pain in VAS scale reached 7.37 ±1.86 points and it significantly lowered life quality of ill subjects. The results regarding life quality in four life domains (i.e. physical, psychological, social and environmental) were definitely better than in the control group.

Outcome Of Solid And Cavitary Pulmonary Nodules In Rheumatoid Arthritis Patients? Case Series, Aysun Aksoy, Derya Kocakaya, Yasemi̇n Yalçinkaya, Emi̇ne Bozkurtlar, Sai̇t Karakurt, Semi̇ha Emel Eryüksel, Güzi̇de Nevsun İnanç

Turkish Journal of Medical Sciences

Background/aim: Rheumatoid pulmonary nodule can be detected in up to 32% of rheumatoid arthritis (RA) patients and approximately one-third of nodules may cavitate. We aimed to evaluate characteristics of patients with RA developing cavitary pulmonary nodular (CPN) lesions under disease-modifying antirheumatic drugs (DMARDs), follow-up of both cavitary and solid nodules, and their outcome with the treatment. Materials and methods: RA patients who presented with CPN lesions during follow-up were recruited retrospectively in this case series analysis. Total numbers and mean diameters of cavitary and solid nodules in each thorax computed tomography (CT) have been determined and followed up by two …

Egfr Blocker Lapatinib Inhibits The Synthesis Of Matrix Metalloproteinases From Synovial Fibroblasts, Demet Yalçin Kehri̇bar, Hakan Emmungi̇l, Neşe Başak Türkmen, Osman Çi̇ftçi̇, Emi̇ne Şalva, Meti̇n Özgen

Turkish Journal of Medical Sciences

Background/aim: Epidermal growth factor receptor (EGFR) family members and their associated ligands may be related to bone and joint destruction in rheumatoid arthritis. Matrix metalloproteinases are responsible for joint and bone tissue degradation. This study is intended to investigate the effect of epidermal growth factor receptor inhibition by lapatinib on the synthesis of matrix metalloproteinases in in vitro. Materials and methods: Synovial fibroblast cell culture was obtained from a patient with rheumatoid arthritis who underwent knee arthroplasty. Interleukin-1ß (IL-1ß) and tumor necrosis factor-∝ (TNF-∝) were added to the cell culture to stimulate synovial fibroblast cells and create an inflammatory character. …

Relation Between Neuropathic Pain And Serum Levels Of Vitamin D In Egyptian Patients With Rheumatoid Arthritis, Enas A. Abdelaleem, Mervat I. Abdelazeem, Rabab A. Mohamed, Shaimaa S. Anwar

Menoufia Medical Journal

Objectives This study aims to measure vitamin D serum levels in Egyptian patients with rheumatoid arthritis (RA) and assess its association with neuropathic pain (NP). Patients and methods The present study was conducted on 70 RA patients. NP was evaluated by the Leeds Assessment of Neuropathic Symptoms and Signs, visual analog scale (VAS) was used to assess the degree of pain, disease activity score (DAS-28) was used to assess activity, and modified health assessment questionnaire (mHAQ) was used to assess quality of life. Serum vitamin D levels were measured for all the patients by ELISA. Results RA patients with NP …

Contribution Of The Human Microbiome And Proteus Mirabilis To Onset And Progression Of Rheumatoid Arthritis: Potential For Targeted Therapy, Jessica Kerpez, Marc Kesselman, Michelle Demory Beckler

Internet Journal of Allied Health Sciences and Practice

The human microbiome has been shown to play a role in the regulation of human health, behavior, and disease. Data suggests that microorganisms that co-evolved within humans have an enhanced ability to prevent the development of a large spectrum of immune-related disorders but may also lead to the onset of conditions when homeostasis is disrupted. In many conditions, a link between dysbiosis (microbial imbalance or microbiome upset) has been identified and associated with immune conditions such as rheumatoid arthritis (RA). This review provides insight into how an individual’s unique microbiome, combined with a genetic predisposition and environmental factors may lead …

Dental And Temporomandibular Joint Alterations In Rheumatoid Arthritis Patients Andtheir Association With Salivary Oxidative Stress, Deni̇z Yaman, Duygu Göller Bulut, Gülbahar Ustaoğlu, Emre Avci, Murat Taşçi

Turkish Journal of Medical Sciences

Background/aim: Rheumatoid arthritis (RA) is the most extensive inflammatory arthritis causing permanent deformities in the joint. Increasing evidence suggests that oxidative stress is a substantial factor in the pathogenesis of RA. This study aimed to examine the salivary oxidant-antioxidant status of RA and control groups and to compare these biomarkers by correlating them with disease activity, acute phase reactants, and clinical findings. Materials and methods: Age and sex-matched 60 participants including 30 patients with RA and 30 control (50 females, 10 males; mean age: 42.62 ± 10.89 years) were evaluated. RA disease activity and severity were evaluated by the disease …

The Inhibition Of Src Kinase Suppresses The Production Of Matrix Metalloproteinases Infrom Synovial Fibroblasts And Inhibits Mapk And Stats Pathways, Demet Yalçin Kehri̇bar, Meti̇n Özgen, Servet Yolbaş, Ahmet Yildirim, Neşe Başak Türkmen, Ebru Önalan, Osman Çi̇ftçi̇, İbrahi̇m Hani̇fi̇ Özercan, Süleyman Serdar Koca

Turkish Journal of Medical Sciences

Background/aim: The purpose of this study was to investigate the antiarthritic potentials of the inhibition of Src kinase in vivo and in vitro settings. Materials and methods: Arthritis was induced by intradermal injection of chicken type II collagen combined with incomplete Freund's adjuvant (collagen induced arthritis [CIA] model) in Wistar albino rats. One day after the onset of arthritis, dasatinib, a potent Src kinase inhibitor, (5 mg/kg/day) was given via oral gavage. Tissue Src, Fyn, MAPK and STAT mRNA expressions were determined by real-time polymerase chain reaction. On the other hand, fibroblast like synoviocytes (FLSs) were harvested patients with rheumatoid …

Efficacy, Retention, And Safety Of Tofacitinib In Real-Life: Hur-Bio Monocentric Experience, Emre Bi̇lgi̇n, Furkan Ceylan, Emi̇ne Duran, Bayram Fari̇soğullari, Ertuğrul Çağri Bölek, Gözde Kübra Yardimci, Levent Kiliç, Ali̇ Akdoğan, Ömer Karadağ, Şazi̇ye Şule Apraş Bi̇lgen, Sedat Ki̇raz, Ali̇ İhsan Ertenli̇, Umut Kalyoncu

Turkish Journal of Medical Sciences

Background/aim: To assess the real-life efficacy, retention rate, and safety data of tofacitinib in rheumatoid arthritis (RA) patients. Materials and methods: We analyzed all patients registered in the HURBİO database who received at least 1 dose of tofacitinib. Patients who received at least one dose were included in retention analysis; patients with at least 1 control visit were included in efficacy and safety analysis. Factors predicting good response at the last follow-up visit were analyzed by logistic regression analysis. Drug retention rates were calculated using the Kaplan-Meier method and predictors of drug retention were determined by Cox proportional hazard model. …

Preferences Of Inflammatory Arthritis Patients For Biological Disease-Modifyingantirheumatic Drugs In The First 100 Days Of The Covid-19 Pandemic, Umut Kalyoncu, Yavuz Pehli̇van, Servet Akar, Ti̇muçi̇n Kaşi̇foğlu, Gezmi̇ş Ki̇myon, Ömer Karadağ, Hüseyi̇n Edi̇z Dalkiliç, Ali̇ İhsan Ertenli̇, Levent Kiliç, Emi̇ne Duygu Ersözlü, Cemal Bes, Hakan Emmungi̇l, Ridvan Mercan, Eli̇f Edi̇boğlu, Ni̇lüfer Alpay Kanitez

Turkish Journal of Medical Sciences

Background/aim: To evaluate treatment adherence and predictors of drug discontinuation among patients with inflammatory arthritis receiving bDMARDs within the first 100 days after the announcement of the COVID-19 pandemic. Materials and methods: A total of 1871 patients recorded in TReasure registry for whom advanced therapy was prescribed for rheumatoid arthritis (RA) or spondyloarthritis (SpA) within the 3 months (6-9 months for rituximab) before the declaration of COVID-19 pandemic were evaluated, and 1394 (74.5%) responded to the phone survey. Patients' data regarding demographic, clinical characteristics and disease activity before the pandemic were recorded. The patients were inquired about the diagnosis of …

Effects Of The Covid-19 Pandemic On Psychology And Disease Activity In Patients Withankylosing Spondylitis And Rheumatoid Arthritis, Şaki̇r Gica, Yasemi̇n Akkubak, Zaki̇re Kübra Aksoy, Adem Küçük, Erkan Cüre

Turkish Journal of Medical Sciences

Background/aim: The COVID-19 outbreak is known to increase stress levels of most patients with chronic diseases. Patients with ankylosing spondylitis (AS) and rheumatoid arthritis (RA) are highly susceptible to environmental stress. In the current study, we aimed to determine how the COVID-19 pandemic psychologically affected patients with chronic progressive diseases such as AS and RA and the effects of these psychological factors on disease activity. Materials and methods: Age and sex-matched patients with AS (n = 80), RA (n = 80), and healthy controls (n = 80) were included in the study. All participants were evaluated with the "Perceived COVID-19 …

A Vision- And Life-Threatening Case Of Peripheral Ulcerative Keratitis, Len V. Koh Od, Megan E. Mcchesney Md, Chad E. Gosnell Od, Ryan N. Ngo Od

Optometric Clinical Practice

Background: Peripheral ulcerative keratitis (PUK) is a rare but severe ocular manifestation most commonly associated with rheumatoid arthritis amongst other autoimmune diseases. Quick diagnosis and co-management with corneal specialist and rheumatologist are crucial to preserve vision and life. A rare case of PUK associated with rheumatoid arthritis (RA) is presented with updates on current understanding and co-management of this condition.

Case Report: A 76 year-old Caucasian male presented to the eye clinic on a Friday as a new patient, with a chief complaint of a red right eye started two weeks ago and was treated with erythromycin ointment, but it …

Paraoxonase-1 Enzyme Activity In Rheumatoid Arthritis Patients: Association With Carotid Intima-Media Thickness?, Ahmed R. Tawfeek, Aly M. El-Kholy, Mohamed Z. Nouh, Sabry A. Shoeib, Waleed M. Fathy

Menoufia Medical Journal

Objectives The aim was to find the relationship of biochemical determinants of paraoxonase-1 (PON1) enzyme activity with carotid intima-media thickness (IMT) as a surrogate marker of atherosclerotic cardiovascular (CV) disease risk in patients with rheumatoid arthritis (RA). Background There is strong correlation between patients with RA and CV morbidity and mortality that cannot be explained by traditional risk factors alone. And this could be due to abnormal function of high-density lipoproteins (HDL). HDL promotes cholesterol efflux, as well as protects low-density lipoprotein (LDL) against oxidation, and this ability has been referred to as an 'anti-inflammatory' function because the lipid oxidation …

Arthritis In Chronic Hepatitis C Infection: Is It Rheumatoid Like Arthritis Or True Rheumatoid Arthritis?, Jefri P. Susanto, Syifa Mustika, Bogi Pratomo

Jurnal Penyakit Dalam Indonesia

No abstract provided.

Handheld Dermatoscopy As An Easy-To-Use Capillaroscopic Instrument In Rheumatoid Arthritis: A Cross-Sectional Study, Ömer Faruk Elmas, Mehmet Okçu, Abdullah Demi̇rbaş, Necmetti̇n Akdeni̇z

Turkish Journal of Medical Sciences

Background/aim: Nailfold video capillaroscopy is considered as a reliable method for evaluating peripheral microangiopathy in rheumatologic diseases. In this study, we aimed to demonstrate the utility of handheld dermatoscopy as an easy-to-use nailfold capillaroscopic instrument in patients with rheumatoid arthritis. Materials and methods: This cross-sectional study included patients with rheumatoid arthritis and healthy subjects. A handheld dermatoscopic examination of proximal nail fold was performed in each subject. The possible correlation of capillaroscopic findings with disease activity was evaluated using the disease activity score 28 (DAS28). Results: A total of 59 patients with rheumatoid arthritis and 60 healthy subjects were enrolled …

Mango Ginger (Curcuma Amada) Inhibits Collagen-Induced Arthritis By Modulatinginflammatory Cytokine Levels In Rats, Ahmet Karataş, Cemal Orhan, Mehmet Tuzcu, Nurhan Şahi̇n, İbrahi̇m Hani̇fi̇ Özercan, Süleyman Serdar Koca, Vijaya Juturu, Kazi̇m Şahi̇n

Turkish Journal of Medical Sciences

Background/aim: Mango ginger (MG: curcuma amada) has antioxidant and antiinflammatory activities. The aim was to evaluate the antiarthritic potential efficacy of MG on collagen-induced arthritis. Materials and methods: Twenty-one female Wistar-albino rats were divided into three groups. Arthritis was induced by intradermal injections of type II collagen and Freund's adjuvant. MG extract was orally administered starting from the first collagen injection. TNF-α, IL-6, IL-17, obestatin, sclerostin, and DKK-1 serum levels were determined, and perisynovial inflammation and cartilage-bone destruction in the paws were histologically evaluated. Moreover, joint tissue TNF-α, IL-17, NF-κB, and COX-2 levels were analyzed. Results: TNF-α, IL-17, IL-6, and …

Correlation Between Carotid Intima-Media Thickness And Serum Tnf-Alpha Levels In Female With Rheumatoid Arthritis Of Different Ethnicities: A Single-Centre Experience In Malaysia, Kek Xin Yi, Asrul A. Wahab, Mohamad Norazrin Mohd Abas, Siti Amira Kamarul Abdul Wahid, Faridah Hanun Othman, Mohd. Shahrir Mohamed Said

Makara Journal of Health Research

Background: Rheumatoid arthritis (RA) is a destructive chronic inflammatory disease with intra- and extra-articular manifestations. It is associated with accelerated formation of arteriosclerosis. The aim of this study was to ascertain the correlation between endothelial dysfunction using carotid intima–media thickness (cIMT) and tumor necrosis factor-alpha (TNF-α) levels among the three main ethnic groups in Malaysia: Malay, Chinese, and Indian. Methods: This cross-sectional study included 23 females with RA belonging to three different ethnic groups who were free from cardiovascular risk factors. Blood sample was taken from each patient to measure serum TNF-α level, C-reactive protein (CRP), and erythrocyte …

Attenuation Of Complete Freund's Adjuvant-Induced Arthritis By Different Dilutions Of Eupatorium Perfoliatum And Crotalus Horridus And Their Safety Evaluation, Surender Singh, Karwasra Ritu, Prerna Kalra, Debadatta Nayak, Anil Khurana, Raj Manchanda

Indian Journal of Research in Homoeopathy

Objective: The aim of this study was to investigate, the inhibitory effect of the homoeopathic drugs – Eupatorium perfoliatum and Crotalus horridus in experimental models of inflammation and Complete Freund's Adjuvant (CFA)-induced arthritis with evaluation of their safety aspects by acute and subacute toxicity studies. Materials and Methods: Animals were divided into eight groups (n = 6). Eupatorium perfoliatum and Crotalus horridus in different dilutions (6CH, 12CH, 30CH and 200CH) were administered orally, daily during the study period of 21 days, and their effect on joint dysfunction was evaluated by measuring joint diameter in CFA-induced arthritis model. In addition, inflammatory …

Laryngeal Assessment Of Patients With Rheumatoid Arthritis Using Laryngeal Photodocumentation, Alaa Labeeb, Asmaa El-Dessouky, Eman Ezzat, Hossam El-Dessouky, Mohamed Baraka

Menoufia Medical Journal

Objective The aim was to assess the prevalence of dysphonia and laryngeal changes upon videolaryngoscopic examination of patients with rheumatoid arthritis (RA). Background RA effects on larynx vary from mild asymptomatic effect to life-threatening conditions. Many authors have emphasized the need of studies in different communities on its effect. In Egypt, the knowledge regarding its manifestations on the larynx, as well as its laryngeal alterations, is limited. Patients and methods A total of 79 patients diagnosed as having RA in Menoufia University Hospitals from March 2015 to March 2017 were assessed by taking history and asking about different laryngeal complaints …