Medicine and Health Sciences Commons^™

Cochlear Pathology In Preeclamptic Rats: Protective Effects Of Vitamin D And Magnesium Sulfate, Mustafa Altintaş, Eni̇s Hi̇di̇şoğlu, Alexandra Cernomorceno, Nuray Ensari̇, Nevreste Di̇dem Sonbay Yilmaz, Özer Erdem Gür, Hülya Eyi̇gör, Züleyha Di̇lek Gülmez, Erdoğan Bulut, Serap Şi̇rvanci, Selahatti̇n Kumru

Turkish Journal of Medical Sciences

Background/aim: This study investigated the possible degeneration in cochlear morphology induced by preeclampsia (PE) and the therapeutic/preventive effect of vitamin D (Vit D) and magnesium sulfate (MgSO4) used separately and together on feto-maternal outcomes. Materials and methods: We created PE in rats using a reduced uterine perfusion pressure (RUPP) animal model and recorded blood pressure (BP), embryonic survival (ES), and embryonic weight (EW) and evaluated cochlear morphology by electron microscopy. Results: The PE group had elevated BP, a decreased number and weight of live pups, and significant degeneration in the cochlea compared to the sham group. In the PEV group, …

Comparative Study Between Serum Vitamin D Levels In Patients With Pre Eclampsia Versus Healthy Pregnant Women, Mofeed Fawzy Muhamed, Muhamed Ahmed Abdelmoaty, Mohammed Mahmoud Ahmed El Desoukey

Al-Azhar International Medical Journal

Background: Preeclampsia etiology remains a mystery, a multitude of theories propose aberrant placental implantation and deviant trophoblastic invasion. Clinical studies examining the link between vitamin D concentrations and poor pregnancy results like preeclampsia have shown mixed findings.

Objective: To measure serum concentrations of vitamin D in pre-eclamptic gestated women and to compare them with their healthy counterparts.

Subjects and methods: After the 20th week of gestation, a prospective case control research was done on 100 gestating women: 50 gestating women with preeclampsia and 50 gestating women without preeclampsia (controls). Subjects whom were selected to assess total 25-OH vitamin D using …

Aggressive Versus Expectant Management Of Preeclampsia With Severe Features Remote From Term (24-34 Weeks), Mohamed Mohamed Gebril, Mohamed Ahmed Abd El-Moaty, Mohamed El-Sayed Ahmed Mohamed

Al-Azhar International Medical Journal

Background; Preeclampsia is a multiorgan, idiopathic illness that only occurs in human pregnancy and the puerperium. after 20 weeks of pregnancy, is indicated by a proteinuria threshold of 300 mg per 24 hours or more, or by a 140/90 mmHg blood pressure cutoff. It accounts for 12%–18% of all maternal deaths linked to pregnancy and is the second most common cause of maternal mortality in the United States.Aim and objectives; to compare the outcomes for mothers and babies in cases of severe preeclampsia far from term between expectant (or conservative) and aggressive (or urgent) care, Subjects and methods; Between January …

Comparative Study Of Mean Platelet Volume In Preeclampsia Versus Normal Pregnancy In 3rd Trimester, Fahd Abdel-Aal Elomda, Ahmed Mohammed Saeed, Hany Abdelhakim Abdelrahman, Ahmed Tarek Ahmed Rashwan

Al-Azhar International Medical Journal

Background; After twenty weeks of pregnancy, preeclampsia, a multisystem illness particular to pregnancy, develops and is characterised by hypertension and proteinuria with or without body edoema, resolving by 6-12 weeks postpartum in previous normotensive women, Aim and objectives; Compare the mean platelet volume (MPV) in the third trimester of pregnancy between preeclamptic and healthy pregnant women to see if this parameter is indicative of preeclampsia. Subjects and methods; This case control study was performed conducted at Al-Hussein Hospitals and Air Force General Hospital. The study included 80 pregnant women in their third trimester were selected to participate in the study, …

The Implications Of Cholecalciferol Supplement On Prevention Of Preeclampsia In Past Preeclamptic Pregnant Women, Fahd Abdel-Aal Elomda, Ahmed Mohammed Saeed, Mahmoud Abdelatif Hashish, Hany Abdelhakim Abdelrahman, Mohamed Samir Mohamed Mosa

Al-Azhar International Medical Journal

Background: Pre-eclampsia (PE) is characterized by edema, proteinuria, and hypertension (≥0.3 g/24 h of protein in the urine (1+ dipstick) on two separate occasions, spaced ≥six hours apart). It complicates 2% to 8% of pregnancies and is a significant source of maternal and neonatal illness and death. Eclampsia, diffuse intravascular coagulation, and the HELLP syndrome are among the side effects of PE. Fetal death and IUGR are risks to the fetus. Clinical research has linked low vitamin D levels to unfavorable pregnancy results because vitamin D is crucial throughout pregnancy. Aim: The study's objective is to assess the impact of …

Relation Of Multimineral-Vitamin D Supplementation And The Risk Of Preeclampsia, Abear El Shabacy, Mohamed A. El-Naggar, Mohamed S. A. Emarah, Osama S. Eltaher, Saher H. Qushwa

Journal of Medicine in Scientific Research

Background The objective of this study was to determine the favorable effects of multimineral-vitamin D supplementation on pregnancy outcomes among women at risk for preeclampsia. Patients and methods This randomized double-blind controlled clinical trial was conducted among 46 women at risk for preeclampsia at 27 weeks of gestation, with positive roll-over test. Pregnant women were randomly assigned to receive either the multimineral-vitamin D supplements (n = 23) or the placebo (n = 23) for 9 weeks. Multimineral-vitamin D supplements were containing 800 mg calcium, 200 mg magnesium, 8 mg zinc, and 400 IU vitamin D3. Fasting blood samples …

Low-Dose Combined Spinal-Epidural Versus Conventional Epidural Anesthesia For Elective Cesarean Section In Severe Preeclampsia, Amir R. Youssef, Ayman A. Radi, Khaled M. Gaballah, Mamdouh E. Lotffy, Nevine M. Soliman

Menoufia Medical Journal

Objective The aim was to compare low-dose combined spinal-epidural and conventional epidural anesthesia for elective cesarean section in patients with severe preeclampsia. Background Severe preeclampsia endangers the life of the mother and/or the fetus through decreasing the blood flow to the placenta, leading to growth retardation, low birth weight, preterm birth, breathing difficulties to the newborn, placental abruption, heavy bleeding, HELLP syndrome, eclampsia, cerebrovascular stroke or hemorrhage, pulmonary edema, renal failure, liver failure, and disseminated intravascular coagulopathy, and also it may end up in death. Patients and methods This study included 60 patients with severe preeclampsia undergoing elective cesarean section. …

Moving Towards Justice: Reducing Encounters Of Preeclampsia In Adolescent Maternal Health, Shaunesse' Jacobs Plaisimond, George Hodulik, Molly Wilde

Journal of Health Disparities Research and Practice

Using data from the Nulliparous Pregnancy Outcomes Study: Monitoring Mothers-to-Be (nuMoM2b), several relationships were explored between nutrition and diet, likely attributed to education, culture, training, and habits around food. While these factors remain relevant and worth pursuing, data analysis implied that the most significant issue remaining is access to healthcare. Across race, age, and nutrition consumption, if pregnant people make higher incomes—inferring better access to healthcare and higher-quality nutrients, then their risk of preeclampsia is reduced. Accordingly, this paper performs an extensive literature review of the intersection of extreme maternal age and nutrient intake as a significant factor for preeclampsia. …

Maternal Serum Vitamin D Level In Patients Complicated By Preeclampsia, Alaa M. Abdelgaied, Amira A. Fathey, Esraa A Elsayed Atiah, Mohammad A. El Said

Menoufia Medical Journal

Objectives To evaluate the relationship between maternal serum vitamin D level and severity of preeclampsia. Background Pregnant women with preeclampsia are susceptible to pulmonary edema, coagulation defects, and renal failure. Vitamin D is thought to play a significant role in preeclampsia as an immune modulator. It may help in producing an appropriate maternal immune response to the placenta preventing the release of antiangiogenic factors into the bloodstream and modulating hypertension. Patients and methods A case–control study was conducted at Department of the Obstetrics and Gynecology, Menoufia General Hospital and Menoufia University Hospital from June 2019 till October 2020. The study …

Comparison Of Pregnancy Complications In Unintended And Intended Pregnancy: A Prospective Follow-Up Study, Mitra Eftekhariyazdi, Malihe Mehrbakhsh, Mahboubeh Neamatshahi, Manijeh Yousefi Moghadam

BioMedicine

Background and Objectives: Unintended pregnancy, as a pregnancy that is mistimed, unplanned or unwanted at the time of conception, is a common experience worldwide that puts mothers at risk for mental stress and its pregnancy complications. The aim of this study was to compare three common pregnancy complications, including preeclampsia, preterm labor, and low birth weight, between unintended and intended pregnancies in Sabzevar, northeast Iran in 2019.

Materials and Methods: This prospective follow-up study was conducted on 200 pregnant women (100 intended and 100 unintended pregnancies) who were between 18 and 35 years old and were referred for …

Tumor Necrosis Factor Alpha Snp Variant In Promoter Region G308a, Cause Preeclampsia During Pregnancy In Pakistani Women, A Case Control Study, Azizah Ziauddin, Sadia Ahmad, Asad Iqbal, Abdul Majid Khan, Shahid Mahmood Baig

Journal of Bioresource Management

Preeclampsia (PE) is a very common critical condition during pregnancy. As PE is a high-risk condition during pregnancy, occurring in 25% of all pregnancies, worldwide. In women with PE there is an increase in hypertension and albuminuria. Elevated blood pressure can be life-threatening after 20^th week of pregnancy. Single nucleotide variation in gene sequence can be disease causing, among these pathogenic SNPs, a variant in TNF-α, G308A is analyzed in many studies as a causative variant to cause preeclampsia. In this case control study fifty patients and fifty healthy individuals were enrolled for analysis of TNF-α promoter region …

Study Of Placental Laterality With Uterine Artery Doppler In The Prediction Of Preeclampsia, Ahmed E. Nasser, Heba F. Salama, Hesham S. Mahmoud, Nasser K. Abd El-Aal, Osama A. El Kelany

Menoufia Medical Journal

Objective To demonst rate if placental laterality combined with uterine artery Doppler can be used as a predictor for the development of preeclampsia. Background The uteroplacental blood flow may be deficient in cases with lateral placenta, and this may facilitate development of preeclampsia. Placenta is considered lateral when 75% or more of the placental mass is located at one side of the midline of uterine cavity. Uterine artery Doppler was done to all cases to find out high resistance index and abnormal protodiastolic notch in Doppler waveform. Patients and methods Ultrasonography was done for all participants at 18–22 weeks of …

Pattern Of Lipid Profile In Pregnancy And Its Impact On The Gestational Course, Ashraf Reda, Awni Gamal, Gehad Gamal, Marwa Sharaf, Mohamed Rezk, Ommaima Idris

Menoufia Medical Journal

Objective The aim was to screen lipid profile in pregnancy and assess the association between second trimester maternal lipid profile and gestational outcome. Background Major changes in lipid profile occur during normal pregnancy and significant association with gestational complications could be confirmed. Materials and methods This cohort study included 94 women with maternal lipid profile assessed during the second trimester (16–18 weeks). Serial antenatal visits were conducted to record the development of maternal gestational hypertension (GH), preeclampsia (PE), gestational diabetes mellitus (GDM), and low birth weight. Results Lipid profile components in pregnancy are higher than normal references. Meanwhile, GH was …

Maternal Chronic Oral Infection With Periodontitis And Pericoronitis As A Possible Risk Factor For Preeclampsia In Egyptian Pregnant Women (Microbiological And Serological Study)., Lobna Azziz, Hala El-Menoufy, Rehab Tarek Elsharkawy, Mona Z. Zaghloul, Dina Sabry

Future Dental Journal

Background: Several studies have hypothesized that oral infection may increase the risk of preeclampsia. We explore the relationship between chronic oral infection and the risk of preeclampsia in Egyptian pregnant women. Methodology: Forty preeclamptic women with periodontitis and/or pericoronitis (group I) and 40 control subjects having periodontitis and/or pericoronitis (group II) were subjected to microbiological assessment of subgingival plaque, pseudo-pocket and placental samples. TNF-a was determined in gingival crevicular fluid (GCF), saliva and serum by ELISA and real time PCR. Results: There was no statistically significant difference between the two groups as regards to subgingival plaque and pericoronal pseudo-pocket organisms …

Cystatin C And Β2 Microglobulin In Preeclampsia: A Prospective Study, Ahmed A. Sonbol, Haitham A. Hamza, Hamed E. Ellakwa, Mohamed A. Elsayed, Mohamed S. A. Soliman

Menoufia Medical Journal

Objective To study the plasma levels of β-2-microglobulin (β2M) and cystatin C in patients with preeclampsia. Background The plasma level of cystatin C has been reported to have a better diagnostic performance for diagnosing preeclampsia. Patients and methods A prospective case–control study was carried out on 20 women diagnosed as having preeclampsia as well as 20 pregnant healthy. All patients attended the Obstetrics and Gynecology Department and outpatient clinic of Menoufia University Hospital, Menoufia Governorate, and Suez Insurance Hospital, Suez Governorate, during the study period from December 2016 to November 2017. Full history, routine, physical examination, and other investigations were …

Changes Of The Choroid In Preeclampsia And Healthy Pregnant Women By Using Optical Coherence Tomography, Asmaa M. Ibrahim, Hatem M. Marey, Mai A. Mokhtar

Menoufia Medical Journal

Objective The aim of the study is to evaluate choroidal thickness alteration in women with preeclampsia and compare with healthy pregnant and nonpregnant controls by using optical coherence tomography (OCT). Background Pregnancy is a predisposing factor for central serous chorioretinopathy. Choroidal thickness (CT) increases in central serous chorioretinopathy and this study evaluates changes in computed tomography (CT) during pregnancy and preeclampsia. Patients and methods This was a cross-sectional study conducted at Menoufia University Hospital Ophthalmology Department during the period from April 2018 to March 2019 on 66 eyes of 33 patients divided into groups. Each group had 22 eyes. Group …

Three-Dimensional Sonographic Assessment Of Placental Volume And Vascularization In Pregnancies Complicated By Hypertensive Disorders, Abd Elhamid E. Shaheen, Emad A. Soliman, Hamed H. E. Yassin, Mohammed A. Emarah

Menoufia Medical Journal

Objective The aim was to compare placental volumes (PVs) and vascularization between normotensive pregnant women and women with hypertensive disorders using three-dimensional sonography. Background Hypertensive disorders in pregnancy are responsible for substantial maternal and fetal morbidity and mortality. Materials and methods This study was conducted at the Outpatient Clinic and Obstetric Departments of Shebin El Kom Teaching Hospital from February 2017 to January 2018. This study included 60 pregnant women, among which 20 were with normal blood pressure which served as the control group (group 1) and 20 were having chronic hypertension (group 2), and 20 with mild preeclampsia (group …

Assessment Of Circulating Endothelial Cells In Preeclamptic And Normotensive Pregnancies, Ahmed A. Sonbol, Bahaa El-Deen W. El-Aswad, Shymaa A. El Askary, Wael G. Al-Damaty, Waleed M. Fathy

Menoufia Medical Journal

Objective The aim of this study was to assess the level of circulating endothelial cells (CECs) in women with preeclampsia (PE) in comparison with normotensive healthy pregnant controls. Background PE is a medical disorder that may affect pregnant women after 20^th week of gestation, and in this condition, the patients experience new-onset hypertension and new-onset proteinuria or organ dysfunctional. There is placental ischemia with systemic maternal endothelium dysfunction. CECs are mature cells that shed from the endothelium in various diseases associated with vessel damage, and they are characterized as being CD146⁺ and CD45⁻ cells. Patients and methods …

Vascular Responses Of Aortic, Renal, And Uterine Arteries In Suramin-Induced Preeclampsia-Like Syndrome In Rats, Sebi̇le Güler Çeki̇ç, Edi̇p Güvenç Çeki̇ç, Di̇lek Baydar, Meral Tuncer, Güray Soydan

Turkish Journal of Medical Sciences

Background/aim: Suramin is a potent angiogenesis inhibitor in rodents and attenuates placental development in rat pregnancy. We aimed to produce preeclampsia-like syndrome by suramin administration in rats and to investigate the functional responses in aortic, renal, and uterine arteries. Materials and methods: Pregnant and nonpregnant wistar rats received suramin (100 mg/kg, intraperitoneal) or equal volume of saline on days 10 and 11. Blood pressures of rats were observed daily. On the day 20, rats were executed. Protein levels in urine were measured and fetuses, placentas, and kidneys were weighted and evaluated. Thoracic aorta, renal, and uterine arteries were removed for …

Possible Causes Of Preeclampsia And Potential Treatments, Helene Weinreb

The Science Journal of the Lander College of Arts and Sciences

Preeclampsia is a common complication of pregnancy characterized by hypertension and proteinuria. Its symptoms are well-defined, but the pathophysiology is not fully understood. This paper analyzes several of the most credible causes of this syndrome and attempts to relate these to the known risk factors. Current preeclampsia treatments are examined, and special focus is given to novel experimental treatments which offer hope of ending preeclampsia and eclampsia.

Immunohistochemical Localization Of Podoplanin In The Placentas Of Hiv-Positivepreeclamptic Women, Onankoy Onyangunga, Jagidesda Moodley, Frederick Odun-Ayo, Thajasvarie Naicker

Turkish Journal of Medical Sciences

Background/aim: Impaired lymphatic function is associated with pathological conditions. The presence of placental lymphatics is still under debate. This study evaluates the placental podoplanin expression in normotensive and preeclamptic women with and without HIV. Materials and methods: Normotensive (n = 60) and preeclamptic (n = 120) pregnant women were stratified into early and late onset preeclampsia and further divided by HIV status. Immunostaining was performed using the podoplanin antibody prior to the morphometric image analysis. Results: Podoplanin was immunolocalized in a reticular-like stroma complex within the exchange and conducting villi. The immunoexpression of podoplanin was significantly upregulated in the exchange …

Pilot Study: Placental Weight Ratio In Diabetic Women With Preeclampsia, Lindsey Hancock, Misti Leyva, Phd, Rd/Ld, Christopher Ashton, Phd

Journal of Health Disparities Research and Practice

Birth weight, a simple measure of birth outcome, has a key role in assessing infant health. A primary determinant of birth weight is a well grown, efficient placenta. Placental weight ratio (PWR) reflects the growth of the baby and placenta and is calculated by dividing the placental weight by fetal weight and is a proven useful health indicator. Preeclampsia (PE) is defined as new-onset hypertension and proteinuria during pregnancy and it is a major cause of maternal and fetal death worldwide. PE is associated with large placentae and small-for-gestational-age (SGA) infants; the PWR is expected to be increased in this …

Evaluation Of Cd40 Ligand In Normal Pregnancy And Preeclampsia, Emad F. Abd-Alhalim, Seham A. Khodeer, Shereen M. Abd-El Azeem Neweer, Wael G. El Damaty

Menoufia Medical Journal

Objective: This study was carried out to assess the presence of an inflammatory response during preeclampsia by demonstrating the presence of the CD40 ligand in preeclamptic pregnancies compared with normal pregnancies. Background: Preeclampsia is a multisystem disorder generally appearing after the 20th week of gestation. Worldwide, the incidence of preeclampsia is seen in 2–10% of pregnancies. WHO estimates the incidence of preeclampsia to be seven times higher in developing countries (2.8% of live births) than in developed countries (0.4%). It is characterized by hypertension, proteinuria, vascular abnormalities, and often intrauterine growth retardation. The only effective treatment is delivery of the …

Nf-?? And Sod Expression In Preeclamptic Placentas, Abraham Silva Carmona, Hugo Mendieta Zeron

Turkish Journal of Medical Sciences

Background/aim: Preeclampsia is a leading cause of maternal death in the developing world. Our aim was to quantify and compare messenger (mRNA) expression of nuclear factor-kappa beta (NF-?β) and superoxide dismutase (SOD) in control patients with preeclampsia and without preeclampsia with or without familial hereditary background. Materials and methods: Four groups of patients were formed depending on the presence or absence of preeclampsia and presence or absence of familial history for preeclampsia. NF-?β and SOD were measured in human placentas by real-time quantitative polymerase chain reaction. The 2-ΔΔct analysis method was used to measure the difference in the relative expression …

Pregnancy Induced Microangiopathy, Hellp Or Ttp!, Ahmed Amro, Md, Alaa Gabi, Md, Zeid J. Khitan, Md

Marshall Journal of Medicine

Introduction: Thrombotic thrombocytopenic purpura (TTP) in pregnancy is rare and can be fatal if misdiagnosed.Typically patients present with microangiopathic hemolytic anemia, thrombocytopenia, Altered mental status, fever, and renal abnormalities

Case Description:

We are presenting a case of 26 year old pregnant female presented with elevated BP. She had scattered Bruises in her legs, thighs and arms along with +2 bilateral pitting leg edema. Initial and subsequent laboratory studies showed features of microangiopathic hemolytic anemia (MAHA), which brought up the suspicion of HELLP (hemolysis, elevated liver enzymes, low platelets )syndrome initially. Labor was induced after transfusion of 2 units of PRBCs …

Lipid Profile Alterations And Oxidative Stress In Patients With Preeclampsia: Role Of Black Tea Extract On Disease Management, Ekambaram Padmini, Munuswamy Usha Rani

Turkish Journal of Medical Sciences

To investigate the lipid profile and susceptibility of low-density lipoprotein (LDL) to oxidation in preeclamptic women and to correlate the results with preeclampsia risk in the absence and presence of black tea extract (BTE). Preeclampsia is a disorder of human pregnancy characterized by altered endothelial function, secondary to oxidative stress. Materials and methods: Lipid profile levels and oxidative stress status were investigated in the cord blood of normotensive and preeclamptic patients. LDL susceptibility to oxidation was also monitored in the absence and presence of BTE to examine its protective role. Results: A significant alteration in lipid parameters and enhanced oxidative …

Correlation Between Calprotectin And Oxidized Ldl In Preeclampsia, Bünyami̇n Börekçi̇, Hülya Aksoy, Nuri̇nni̇sa Öztürk, Sedat Kadanali

Turkish Journal of Medical Sciences

Aim: To evaluate the relationship between serum calprotectin and oxidized low density lipoprotein (LDL) in preeclamptic patients. Additionally, we aimed to measure serum malondialdehyde (MDA) levels as an oxidative stress marker. Materials and Methods: Serum calprotectin, oxidized LDL, and MDA levels were measured in a cross-sectional study of 61 preeclamptic patients (39 severe preeclampsia and 22 mild preeclampsia cases) and 20 healthy pregnant subjects. Serum MDA concentration was measured with spectrophotometric methods, and oxidized LDL and calprotectin were measured via enzyme-linked immunoassay (ELISA). Results: Serum calprotectin (P < 0.0001 and P = 0.014) and MDA (P = 0.001 and P = 0.028) levels were significantly higher in the severe and mild preeclampsia groups than in the healthy control group. Serum oxidized LDL concentration was slightly higher, but not did reach a statistically significant level, in the severe preeclampsia group than in the healthy pregnant group (P = 0.2). There was a significant negative correlation between the levels of calprotectin and oxidized LDL (r = -0.34, P = 0.006) in the mild and severe preeclampsia groups. The correlation between calprotectin and MDA was not statistically significant (P = 0.08). Conclusions: The findings suggest that increased calprotectin is associated with preeclampsia. Further study is necessary in order to determine whether or not high calprotectin levels prevent oxidation of circulating LDL in preeclampsia cases.

Placental Heat Shock Protein 70 Overexpression Confers Resistance Against Oxidative Stress In Preeclampsia, Ekambaram Padmini, Bose Vijaya Geetha

Turkish Journal of Medical Sciences

Aims: Preeclampsia is a hypertensive disorder of human pregnancy and a leading cause of premature delivery and fetal growth retardation. The purpose of this study was to evaluate the expression of heat shock protein 70 (HSP70), both constitutive (HSC70) and induced (HSP70) forms, along with oxidative stress status in the placental tissues of normotensive (control group) and preeclamptic pregnancies. Materials and Methods: Placental samples were collected after delivery from normotensive pregnancies and preeclamptic patients (n = 20, each). Lipid peroxidation product malondialdehyde (MDA) and nitrite and nitrate levels, along with antioxidants such as superoxide dismutase (SOD) and glutathione peroxidase (GPx) …

Elevated Serum \Beta-Hcg Levels In Severepreeclampsia, Remzi̇ Gökdeni̇z, Erdal Arigüloğlu, Nursel Bazoğlu, Özcan Balat

Turkish Journal of Medical Sciences

Most current hypotheses regarding the pathophysiologic mechanisms of pregnancy-induced hypertention point to early placental abnormalities. Therefore, we attempted to determine whether serum human chorionic gonadotropin (hCG) levels reflect a different trophoblastic secretory response of preeclampsia. Thirteen pregnant women with severe preeclampsia were matched with twenty-one normotensive pregnant women with singleton pregnancies in the third trimester. Serum b-hCG levels were found to be significantly higher in severe preeclampsia, compared with controls (p

Decreased Placental Adrenomedullin May Play Role In Preeclampsia, Remzi̇ Gökdeni̇z, Muhi̇tti̇n Yürekli̇, Alanur Menekşe, Nursel Bazoğlu

Turkish Journal of Medical Sciences

Adrenomedullin (AdM) is a novel peptide that elicits a long-lasting vasorelaxant activity. It is expressed in several tissues, including adrenal medulla, heart, lung, kidneys, and cultured vascular smooth muscle cells. Also in large amounts, it is present in amniotic fluid and cord blood. The aim of this study was to assess placental AdM secretion in preeclampsia. Placental tissues were collected from seven preeclamptic patients and ten healthy gravidas. Tissue concentration of rat AdM was measured by using reverse-phase high performance liquid chromatography (Cecil 1100). Mann Whitney U test was used for statistical significance. Significance was set at p