Medicine and Health Sciences Commons^™

Female Breast Cancer Survivor’S Perspective Of Support Systems In Trinidad And Tobago, Andrea Mcdonald, Isabella Granderson, Olivia Johnson, Antoinette W. Coward, Brendon Bhagwandeen

The Journal of the Research Association of Minority Professors

Globally, breast cancer is the most common cancer affecting women. The Cancer Registry of Trinidad and Tobago indicated that 45.9% of the breast cancer cases belonged to the African ethnicity, 27.5% Asian Indian, and 14.7% mixed ethnicity. Research on female breast cancer survivors' perspectives on support systems and care within the Caribbean region is limited. Therefore, this study aims to examine female breast cancer survivors' perspective of support systems in Trinidad and Tobago. We conducted a cross-sectional study with 74 cancer survivors attending support groups. To be eligible, the participants had to be females 18 years or older, residents of …

Prevalence Of Breast Cancer Among Patients With Non-Bloody Breast Discharge, Mohamed Ahmed Saeed, Emad Ads Elewesy, Al-Sayed Mohamed Tealeb, Mohamed Hussein Ali Mohamed

Al-Azhar International Medical Journal

Background: Up to 80% of women will have an incidence of nipple discharge, making it the third most prevalent breast-related symptom. Nipple discharge is usually considered as physiologic if it is bilateral, non-bloody from multiple ducts and not associated with mass, pain or hormonal disturbance. Mammography has a poor sensitivity for abnormality identification in individuals with pathologic nipple discharge. As a result, other tests including galactography, ultrasound, MRI, and cytology must be added to mammography. Diagnostic mammography and sub areolar ultrasound are the preferred imaging modalities for pathologic nipple discharge. Aim: Objective of the study is to evaluate the incidence …

Evaluation Of Pattern Of Relapse In Luminal Breast Cancer, Mohamed Ahmed Abdelaziz, Eslam Mohamed Ebrahim, Mohsen Salah El-Din Zikry

Al-Azhar International Medical Journal

Background: The most common molecular subtype of breast cancer worldwide is luminal breast cancer. It has shown a good prognostic profile compared to other types. Despite the immense development of adjuvant treatment in the past years, around 20% of patients with early-stage disease relapse. Aim of the study: To evaluate the relapse pattern in luminal breast cancer and the correlation between luminal types and (AJCC 8th edition). Subject and Methods: A total of 230 luminal breast cancer patients treated at Al-Hussein University Hospital between 2013 and 2018 were analyzed. Patients have been divided into the following groups: luminal A (31%) …

Evaluation Of Outcome In The Management Of Patients With Triple Negative Breast Cancer (Retrospective Study), Taher Moheb Hassan Hamama, Ahmed Yousry Al-Agamawi, Hesham Abbas Al-Abady

Al-Azhar International Medical Journal

Background: The most frequent malignancy in women is breast cancer. Depending on the tumor's morphological traits, clinical characteristics, and hormone receptor levels, treatment outcomes can vary. In modern medicine, the levels of the progesterone receptor (PGR), oestrogen receptor (ER), and human epidermal growth factor receptor 2 (HER2) have been found to be important prognostic markers.

Aim of the work: To evaluate the clinicopathological features among the patients with early-stage triple negative breast cancer regarding progression free survival and overall survival.

Patient and methods: The Clinical Oncology and Nuclear Medicine Department at AL-Hussein University Hospital conducted this retrospective analysis between the …

Classification Of Breast Cancer Histopathological Images Using Semi-Supervised Gans, Balaji Avvaru, Nibhrat Lohia, Sowmya Mani, Vijayasrikanth Kaniti

SMU Data Science Review

Breast cancer is diagnosed more frequently than skin cancer in women in the United States. Most breast cancer cases are diagnosed in women, while children and men are less likely to develop the disease. Various tissues in the breast grow uncontrollably, resulting in breast cancer. Different treatments analyze microscopic histopathology images for diagnosis that help accurately detect cancer cells. Deep learning is one of the evolving techniques to classify images where accuracy depends on the volume and quality of labeled images. This study used various pre-trained models to train the histopathological images and analyze these models to create a new …

Social Support Needs Of Minority Breast Cancer Patients: Significance Of Racial Homogeneity And Kin Composition Of Social Networks, Ganga Vijayasiri, Garth H. Rauscher, Ifeanyi Beverly Chukwudozie, Richard T. Campbell, Richard Warnecke

Journal of Health Disparities Research and Practice

Social support from family and friends assists breast cancer patients navigate a life crisis, but more needs to be understood about specific social network characteristics that can benefit breast cancer patients. To address this need, the primary aim of this study was to identify social network factors that facilitate or reduce social support. Given racially patterned gaps in social support among breast cancer patients, a secondary goal was to identify network characteristics that are linked to gaps in support. We examined these research questions using data from a sample of 915 breast cancer patients (NHWhite=373; NHBlack=377; Hispanic=165) and 4,021 of …

Determining Vitamin D Status: A Comparison Between Diabetic And Non-Diabetic Women With Breast Cancer By Rp-Hplc, Santosh Gunasekaran, Suma M. Natraj, Prashanth Kumar M V

Digital Journal of Clinical Medicine

Background:

Suboptimal levels of Vitamin D, remains a common problem worldwide and its prevalence is high in India, ranging from 70-100%. Several molecular mechanisms have been found about the effects of Vitamin D in modulating glycemic levels and its protective nature in the development of breast cancer. Breast cancer in India is a common problem and studies regarding its association with Vitamin D levels among diabetics remain inconclusive. This study aims to find the association between Vitamin D status and breast cancer in diabetic and non-diabetic women.

Materials and methods:

25 hydroxy vitamin D levels were estimated by RP-HPLC. A …

Microrna-26a-5p As A Potential Predictive Factor For Determining The Effectiveness Of Trastuzumab Therapy In Her-2 Positive Breast Cancer Patients, Sadra Samavarchi Tehrani, Ehsan Zaboli, Farzin Sadeghi, Soraya Khafri, Ansar Karimian, Mahnoosh Rafie, Hadi Parsian

BioMedicine

Background: Breast cancer (BC) is known as the most prevalence type of cancer among women. Trastuzumab, as a cancer drug, has been used broadly in human epidermal growth factor receptor 2 (HER-2) positive BC patients. On the other hand, accumulating evidence has demonstrated that microRNAs involved in pathogenesis BC. Hence, we aimed to investigate the effect of trastuzumab on the expression levels of microRNA-26a in HER-2positiveBC patients.

Methods: This study was conducted on HER-2 positive BC patients and HER-2 Negative BC patients. Serum expression of microRNA-26a were detected by real-time PCR. Then, we assessed the correlation of microRNA-26a level with …

The Serine/Threonine Protein Kinase (Akt)/ Protein Kinase B (Pkb) Signaling Pathway In Breast Cancer, Daniela Miricescu, Camelia Cristina Diaconu, Constantin Stefani, Ana Maria Alexandra Stanescu, Alexandra Totan, Ioana Ruxandra Rusu, Ovidiu Gabriel Bratu, Dan Spinu, Maria Greabu

Journal of Mind and Medical Sciences

According to statistical data published in 2019, breast cancer is among the leading causes of death in women worldwide. The serine/threonine kinase (AKT) or protein kinase B (PkB) signaling pathway is activated by phosphorylation processes, which further is associated with cell growth, proliferation, and survival, but also with activation of glucose metabolism. Mutations of the AKT signaling pathway components (especially PI3KCA and PTEN) have been observed in breast cancer patients, which are associated with resistance to hormonal treatment. Many clinical trials are testing the effect of AKT inhibition in order to block the growth and proliferation of breast cancer cells. …

Cancer Blog Narratives: The Experience Of Under-Fifty Women With Breast Cancer During Different Times After Diagnosis, Maria Luisa Martino, Anna Gargiulo, Daniela Lemmo, Giorgia Margherita

The Qualitative Report

The recent literature shows an increase of breast cancer in women under 50, however still few are the studies which analyse the impact of the disease in this specific target age. This study aims at exploring the most prevalent topics in Italian cancer blogs of women who have received a breast cancer diagnosis before the age of 50, in order to understand their experience of illness and the characteristics of women’s narrations at different times after diagnosis (1 year, 2 years, 3 years). We collected the textual corpus of 4 Italian breast cancer blogs and performed a thematic analysis. Five …

Factors Influencing Breast Cancer Genetic Testing Among High Risk African American Women: A Systematic Review, Shirley Ann Spencer, Carolyn Rodgers, Vickii Coffey

Internet Journal of Allied Health Sciences and Practice

African American women are disproportionately impacted by breast cancer and its associated effects. They have the highest breast cancer mortality rate of all racial and ethnic groups in the U.S., yet, many high risk African American women do not follow-up with genetic testing despite, having a shorter survival rate and more likely to develop malignancies or aggressive forms of breast cancer than white women. Purpose: This review explored breast cancer genetic follow up and barriers among African American women and made recommendations for designing tailored high risk breast cancer programs. Method: The Integrative Model of Behavioral Prediction framework provided …

Disparities In Breast Cancer Stage At Diagnosis: Importance Of Race, Poverty, And Age, Faustine Williams, Emmanuel Thompson

Journal of Health Disparities Research and Practice

This study investigated the association of race, age, and census tract area poverty level on breast cancer stage at diagnosis. The study was limited to women residing in Missouri, aged 18 years and older, diagnosed with breast cancer, and whose cases were reported to the Cancer Registry between 2003 and 2008. The risk, relative risk, and increased risk of late-stage at diagnosis by race, age, and census tract area poverty level were computed. We found that the odds of late-stage breast cancer among African-American women were higher when compared with their white counterpart (OR 1.433; 95% CI, 1.316, 1.560). In …

Exploration Of Antagonist Efficacy For Lpra2 Like Peptide, Ayobami Loye, Ruben R. Gonzalez-Perez, Phd

Journal of Health Disparities Research and Practice

Leptin is a small protein hormone that controls satiety and is produced by adipocytes. Obese people have increased levels of circulating leptin. Excessive leptin levels cause a break down in the control of leptin signaling pathways leading to increased angiogenesis, proliferation, cell migration, invasion, and anti-apoptotic events. Obesity and leptin signaling have been linked to cancer progression. Literature shows that LPrA2 is an effective leptin antagonist as it decreases proliferation of breast cancer cells in vitro.

This project compares the effectiveness of LPrA2 like compounds in breast cancer cell-line MDA-MB-468 (M-468 BCs). We hypothesize that the new peptide antagonists have …

Cox2 Plays An Important Role In Maintenance Of Mammary Cancer Stem Cell Population In Human Breast Cancer Cell Lines, Mayra Garcia, Shehla Pervin, Phd, Easter Thames, Meher Parveen, Phd, Melanie Baker

Journal of Health Disparities Research and Practice

Breast cancer is a malignant growth in the adipose-rich mammary gland. Initiation and progression of breast tumors involve multiple cell types, among which mammary cancer stem cells play an important role. There are two main types of adipocytes; white adipocytes have previously been found to influence the disease while brown adipocytes, which uniquely express uncoupling protein 1 (UCP1), were recently detected in breast tumors.

We have detected Myf5, a transcription factor, which is expressed in the progenitor population of brown adipocytes, in breast cancer cell lines. We also found an association between expression of Myf5 and COX2 (or Ptgs2), which …

Induction Of Dusp9 In Xenografts From Human Breast Cancer Cell Lines Increases Mammary Cancer Stem Cells, Albert Barrios, Meher Parveen, Phd, Easter Thames, Melanie Baker, Shelha Pervin, Phd

Journal of Health Disparities Research and Practice

Breast cancer remains a complex disease that kills 40,000 women every year. Initiation and progression of breast cancer is influenced by heterogeneous groups of cells, including mammary cancer stem cells (MCSCs). Progression of this dreadful disease is driven by many signaling pathways among which MAPK pathway is highly prominent. Since targeting prominent kinases in MAPK pathway has been unsuccessful to control breast cancer, it is important to examine the phosphatases that regulate the activity of these kinases.

Using xenograft model from breast cancer cell lines, our lab has found that during the initial stages of xenograft development (week 1-4, 100-200mg …

Attitudes Toward Breast Cancer Genetic Testing In Five Special Population Groups, Amelie G. Ramirez, Patricia Chalela, Kipling J. Gallion, Edgar Muñoz, Alan E. Holden, Linda Burhansstipanov, Selina A. Smith, Evaon Wong-Kim, Stephen W. Wyatt, Lucina Suarez

Journal of Health Disparities Research and Practice

Purpose: This study examined interest in and attitudes toward genetic testing in 5 different population groups.

Methods: The survey included African American, Asian American, Latina, Native American, and Appalachian women with varying familial histories of breast cancer. A total of 49 women were interviewed in person. Descriptive and nonparametric statistical techniques were used to assess ethnic group differences.

Results: Overall, interest in testing was high. All groups endorsed more benefits than risks. There were group differences regarding endorsement of specific benefits and risks: testing to “follow doctor recommendations” (p=0.017), “concern for effects on family” (p=0.044), “distrust of modern medicine” (p=0.036), …

Prevalence Of Anxiety And Depression And Related Factors In Breast Cancer Patients Receiving Chemotherapy, J. Jobsubin, N. Thavichachart

Chulalongkorn Medical Journal

No abstract provided.