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2024

Universitas Indonesia

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Full-Text Articles in Medicine and Health Sciences

Basic Structure Of The Pharmacophore Virtual Screening Protein 7kg7 For Candidate Therapeutic Options Covid-19, Ahmad Ridha Al Fiqri May 2024

Basic Structure Of The Pharmacophore Virtual Screening Protein 7kg7 For Candidate Therapeutic Options Covid-19, Ahmad Ridha Al Fiqri

Indonesian Journal of Medical Chemistry and Bioinformatics

Coronavirus disease (COVID-19) caused by severe acute respiratory syndrome, namely coronaviruses (SARS-CoV-2) has been a pandemic to date and is contagious with relatively high mortality rates. Various efforts have been made to control the pandemic to finding the best solution to reduce the spread such as rapid detection based on molecular and serological, as well as efforts to find the best medicine for COVID-19 patients continue to be carried out. We analyzed and concluded that the presatovir compound is capable of being a substitute for the native protein ligand 7KG7, this is proved with a ΔG value of -13.22 kcal/mol …


Current Update Of Clinical Therapeutic Strategies For Colon-Targeted Delivery Systems, Risa Widiani Batubara, Fadlina Chany Saputri, Raditya Iswandana Apr 2024

Current Update Of Clinical Therapeutic Strategies For Colon-Targeted Delivery Systems, Risa Widiani Batubara, Fadlina Chany Saputri, Raditya Iswandana

Pharmaceutical Sciences and Research

Oral colon-targeted drug delivery systems represent a significant advancement offering both systemic and local therapeutic effects for a range of intestinal diseases, including irritable bowel syndrome, inflammatory bowel disease, colonic bacterial infections, and colorectal cancer. These systems facilitate the delivery of both small molecules and macromolecular compounds such as peptides, proteins, antibodies, oligonucleotides, RNA, and probiotics. This review provides an up-to-date exploration of the critical factors crucial for the effective design and development of drug delivery systems targeting the colon. The chosen strategy takes into account various aspects of colon physiology that influences the profile of drug release, absorption, dissolution, …


Transdermal Delivery Of Ketoprofen For Osteoarthritis Treatment And Management: A Literature Review On Current Progression, Dwi Asih Ramadhani, Yahdiana Harahap, Erny Sagita, Kartika Citra Dewi Permata Sari, Rr. Kirana Andranilla, Jessica Trisina, Gabriella Frederika Punu, Delly Ramadon Apr 2024

Transdermal Delivery Of Ketoprofen For Osteoarthritis Treatment And Management: A Literature Review On Current Progression, Dwi Asih Ramadhani, Yahdiana Harahap, Erny Sagita, Kartika Citra Dewi Permata Sari, Rr. Kirana Andranilla, Jessica Trisina, Gabriella Frederika Punu, Delly Ramadon

Pharmaceutical Sciences and Research

Arthritis, a diverse spectrum of joint disorders, is characterized by chronic pain and inflammation. Osteoarthritis (OA), the most prevalent form, leads to disabling pain, functional limitations, and reduced mobility. Nonsteroidal anti-inflammatory drugs (NSAIDs) are widely used for managing OA pain, with ketoprofen recognized as one of the effective options. However, oral administration of ketoprofen may cause gastrointestinal irritation. Addressing this issue, Transdermal Drug Delivery Systems (TDDS) emerge as a promising alternative route of administration. TDDS facilitates delivery of various drugs through the skin without undergoing first-pass metabolism. Recent studies have centered on enhancing ketoprofen’s transdermal delivery, particularly focusing on different …


Epidemiology Of Bruxism And Temporomandibular Joint Disorders (Tmd) In Iranian Adults: A Cross-Sectional Study, Parviz Amini, Maryam Sharifi, Reyhane Aftabi, Fatemeh Jahanimoghadam, Hamidreza Jahanimoghadam Apr 2024

Epidemiology Of Bruxism And Temporomandibular Joint Disorders (Tmd) In Iranian Adults: A Cross-Sectional Study, Parviz Amini, Maryam Sharifi, Reyhane Aftabi, Fatemeh Jahanimoghadam, Hamidreza Jahanimoghadam

Journal of Dentistry Indonesia

Objective: The prevalence of bruxism in the literature has been reported differently. The aim of this study was to assess the prevalence of bruxism in patients aged 25–40 who were referred to Kerman Dental School. Methods: This analytical descriptive cross-sectional study was performed on 320 patients referred to the Department of Oral Medicine of Kerman Dentistry Faculty in the age range of 25 to 40 years old. The prevalence of bruxism as well as TMJ disorders were evaluated. Data were collected in a questionnaire and entered into SPSS version 24. Analyzing was done by a chi-square test at …


Perceptions Of Oral Health-Related Care For Children With Autism Spectrum Disorder: A Scoping Review, Ismail Nabil Albhaisi, Shahida Mohd-Said, Yan Jia Lim, Tuti Ningseh Mohd-Dom, Ahmad Shuhud Irfani Zakaria, Colman Patrick Mcgrath Apr 2024

Perceptions Of Oral Health-Related Care For Children With Autism Spectrum Disorder: A Scoping Review, Ismail Nabil Albhaisi, Shahida Mohd-Said, Yan Jia Lim, Tuti Ningseh Mohd-Dom, Ahmad Shuhud Irfani Zakaria, Colman Patrick Mcgrath

Journal of Dentistry Indonesia

Objective: This review aimed to seek insights into the challenges faced by caregivers and children with autism spectrum disorder (ASD) when performing and accessing oral care and their recommendations to overcome the matter. Methods: Six electronic databases were used to search for published English full articles using a standardised strategy and grouped using thematic analysis as findings to the study’s goal. Results: The initial screening found 46 relevant articles, but 21 were deemed eligible. Studies were mostly observational (18 crosssectional surveys and 3 case-controls), retrieving data from online or face-to-face surveys and insurance health info. The perceptions …


Investigation Of The Effect Of The Covid-19 Pandemic On Anxiety Levels And Career Satisfaction Of Dentistry Students, Furkan Kır, Ata Batuhan Bayrak, Mediha Büyükgöze-Dindar Apr 2024

Investigation Of The Effect Of The Covid-19 Pandemic On Anxiety Levels And Career Satisfaction Of Dentistry Students, Furkan Kır, Ata Batuhan Bayrak, Mediha Büyükgöze-Dindar

Journal of Dentistry Indonesia

Objective: This study aimed to investigate the effect of the COVID-19 pandemic on the anxiety levels and career satisfaction of dentistry students. Methods: A total of 220 dentistry students were included in the study. A questionnaire was mailed to dentistry students at Trakya University between June 2021 and January 2022. Beck Anxiety Inventory (BAI) was used to evaluate anxiety levels. Data were analyzed, and p < 0.05 was considered statistically significant. Results: The mean BAI scores of the participants were 14.6 ± 13.6. The anxiety levels of the females were significantly higher than the males (p = 0.004). There was a significant relationship …


Mangosteen Peel Extract Vs Tetracycline Gel In Treatment Of Periodontal Abscess In Type-2 Diabetes – A Randomized Clinical Trial, Ksv Ramesh, Itha Joshna, Gautami S. Penmetsa, Gottumukkala Nvs Sruthima, Pasupuleti Mohan Kumar, Boddeda Anusha, Sathya Valli Apr 2024

Mangosteen Peel Extract Vs Tetracycline Gel In Treatment Of Periodontal Abscess In Type-2 Diabetes – A Randomized Clinical Trial, Ksv Ramesh, Itha Joshna, Gautami S. Penmetsa, Gottumukkala Nvs Sruthima, Pasupuleti Mohan Kumar, Boddeda Anusha, Sathya Valli

Journal of Dentistry Indonesia

Herbal products are gaining popularity due to their diverse biological action and safety. Mangosteen peel extract has antibacterial and anti-inflammatory properties and can be used to treat periodontal diseases. Objective: To compare the efficacy of mangosteen peel extract and tetracycline gel as an adjunct to non-surgical management of periodontal abscess in type-II diabetes patients. Methods: This was a double blinded, randomized clinical trial included 20 Patients with Type-II diabetes. Both test and control groups received NSPT followed by adjunctive local application of mangosteen peel extract and tetracycline gel. Clinical parameters i.e., Probing depth (PPD), Clinical attachment level (CAL), …


Development And Validation Of The Human Aspects Influencing The Oral Healthcare Data Quality (Hai-Dq) Questionnaire Among Primary Oral Healthcare Workers In Malaysia, Alwani Mohd Zuhudi, Syirahaniza Mohd Salleh, Mohd Zulkarnain Sinor, Mohd Zarawi Mat Nor, Basaruddin Ahmad, Sarliza Yasmin Sanusi Apr 2024

Development And Validation Of The Human Aspects Influencing The Oral Healthcare Data Quality (Hai-Dq) Questionnaire Among Primary Oral Healthcare Workers In Malaysia, Alwani Mohd Zuhudi, Syirahaniza Mohd Salleh, Mohd Zulkarnain Sinor, Mohd Zarawi Mat Nor, Basaruddin Ahmad, Sarliza Yasmin Sanusi

Journal of Dentistry Indonesia

Resolving substandard oral healthcare data quality requires identifying the influencing factors. However, no known instrument for such assessment can be used locally. Objective: To develop and validate the HAI-DQ questionnaire for assessing human factors that influence oral healthcare data quality among primary oral healthcare workers in Malaysia. Methods: The HAI-DQ questionnaire was developed based on literature reviews, focus group discussions, and focus observations. Six experts assessed its content validity using the Content Validity Index (CVI), and the Face Validity Index (FVI) was used to establish its face validity through a pre-test involving 30 primary dental personnel. Results: Four …


Effect Of Taper And Pitch On Nickle-Titanium File With Variable Cross Section To Its Cyclic Fatigue (In Silico Study), Yustika Chrysandra, Tunjung Nugraheni, Wignyo Hadriyanto Apr 2024

Effect Of Taper And Pitch On Nickle-Titanium File With Variable Cross Section To Its Cyclic Fatigue (In Silico Study), Yustika Chrysandra, Tunjung Nugraheni, Wignyo Hadriyanto

Journal of Dentistry Indonesia

The geometric design of an endodontic file includes cross-sectional shape, taper, and pitch. NiTi endodontic files of OneCurve (MicroMega) are made of two variations of cross-sectional shape, that is, double-s shaped and triple helix. Various kinds of modifications were made to increase the resistance of the NiTi endodontic files from fracture. Cyclic fatigue is the most common factor that causes a fracture of the endodontic file. Objective: The purpose of this study was to obtain a NiTi endodontic file design that has the best cyclic resistance value based on its taper size and number of pitch. Methods: This …


Comparison Of The Factors Affecting Smile Esthetics With The Patient And Physician Perceptions Using The Smile Esthetic Index, Dilek Özkan Şen, Zeynep Taştan Eroğlu,, Osman Babayiğit,, Fatma Uçan Yarkaç Apr 2024

Comparison Of The Factors Affecting Smile Esthetics With The Patient And Physician Perceptions Using The Smile Esthetic Index, Dilek Özkan Şen, Zeynep Taştan Eroğlu,, Osman Babayiğit,, Fatma Uçan Yarkaç

Journal of Dentistry Indonesia

Objective: This study aimed to evaluate the smile esthetics of individuals and the factors affecting it using the smile esthetic index (SEI) and compare them with the patient’s perception of smile. Methods: Seventy-six patients consisting of 44 females and 32 males who presented to for routine periodontal treatments were included in study. The smile esthetics were evaluated by three researchers on the photographs taken from the patients. The visual analog scala was used for the subjective evaluation of smile esthetics. Results: According to the results obtained from the study, the average of the SEI total scores was …


Effect Of Ultrasonic Combined With Solvent On Gutta-Percha And Bioceramic Sealer Removal In Middle And Apical Third Of The Root Canal: An Ex Vivo Study, Eko Fibryanto, Wiena Widyastuti, Adi Hidayat, Lisiana Hastuty Apr 2024

Effect Of Ultrasonic Combined With Solvent On Gutta-Percha And Bioceramic Sealer Removal In Middle And Apical Third Of The Root Canal: An Ex Vivo Study, Eko Fibryanto, Wiena Widyastuti, Adi Hidayat, Lisiana Hastuty

Journal of Dentistry Indonesia

Objective: This study aims to investigate the effectiveness of ultrasonic tip with and without solvent in removing gutta-perca and bioceramic sealer from the middle and apical third of the root canals. Methods: This is a true experimental study with randomized pretest-posttest control group design. Eighteen freshly extracted straight single-rooted mandibular first premolars were confirmed by CBCT and selected. The teeth were decoronated until a length of 16 ± 0.5mm. The teeth were prepared and obturated using gutta-percha and bioceramic sealer with a hydraulic condensation technique. Pre-instrumentation CBCT imaging of all teeth was carried out to obtain the initial volume of …


Determination Of Demographic, Systemic, And Radiographic Characteristics Of Patients Applied To The Oral And Maxillofacial Radiology Clinic, Ayşe Taş, Selmi Yardimci Apr 2024

Determination Of Demographic, Systemic, And Radiographic Characteristics Of Patients Applied To The Oral And Maxillofacial Radiology Clinic, Ayşe Taş, Selmi Yardimci

Journal of Dentistry Indonesia

Objective: Anamnesis, extraoral intraoral examination, radiographic examination, and other special examination methods are used to diagnose diseases in the oral and maxillofacial regions. The aim of this study was to establish the demographic, systemic, and radiographic characteristics of the patients by analyzing the records of patients who were treated at the Oral and Maxillofacial Radiology Clinic of the University Faculty of Dentistry. Methods: The anamnesis and diagnostic records of patients who were treated at the OMR clinic between 01.01.2013 and 31.12.2019 and the radiographic records of the patients referred to the X-ray department were retrospectively analyzed. The number of patients …


Reliability Of Three-Dimensional Micro-Computed Tomography Root Canal Analysis Using Drishti Software: A Pilot Study, Nurulaqmar Iwani Samsudin, Marlena Kamaruzaman, Afiq Azizi Jawami Apr 2024

Reliability Of Three-Dimensional Micro-Computed Tomography Root Canal Analysis Using Drishti Software: A Pilot Study, Nurulaqmar Iwani Samsudin, Marlena Kamaruzaman, Afiq Azizi Jawami

Journal of Dentistry Indonesia

In recent years, micro-computed tomography (micro-CT) has become a promising tool for non-destructive imaging and the study of root canal morphology in endodontics. However, the reliability of such analyses heavily relies on the accuracy and consistency of the software used for image processing. Objective: This study aims to investigate the reliability of two different micro-CT voxel sizes using open-source three-dimensional (3D) software (Drishti v3.0) used to identify and quantify the Apical Foramen (AF) and Apical Constriction (AC) in mandibular premolars. Methods: Eight mandibular premolars were divided into two groups, with four samples in each group. Samples were scanned using a …


Hubungan Rasio Neutrofil Limfosit Terhadap Komplikasi Kardiovaskular Pada Pasien Penyakit Ginjal Kronik Hemodialisis, Thariq Hikmatul Akmal, Agung Susanto, Ratih Tri Kusuma Dewi, Agus Jati Sunggoro Mar 2024

Hubungan Rasio Neutrofil Limfosit Terhadap Komplikasi Kardiovaskular Pada Pasien Penyakit Ginjal Kronik Hemodialisis, Thariq Hikmatul Akmal, Agung Susanto, Ratih Tri Kusuma Dewi, Agus Jati Sunggoro

Jurnal Penyakit Dalam Indonesia

Introduction. The neutrophil-to-lymphocyte ratio (NLR) is a simple parameter to assess the inflammatory status, especially in chronic kidney disease (CKD) patients experiencing capillary damage due to increased glomerular capillary pressure. In a state of vascular endothelial inflammation, there is a higher tendency to form atherosclerotic plaques and calcification that can induce cardiovascular events such as heart failure, coronary heart disease, and stroke. This study aimed to determine the relationship between the NLR and cardiovascular complications in CKD patients undergoing hemodialysis.

Methods. An analytical observational study with cross-sectional approach was conducted among 119 CKD patients undergoing hemodialysis at Dr …


Evaluasi Pengukuran Kekakuan Limpa Dalam Memprediksi Perdarahan Varises Esofagus Berulang Pada Pasien Sirosis Hati, Andi Cahaya Tahir, Juferdy Kurniawan, Marcellus Simadibrata, Aulia Rizka, Hamzah Shatri, Cosmas Rinaldi A. Lesmana, Nadia Ayu Mulansari Mar 2024

Evaluasi Pengukuran Kekakuan Limpa Dalam Memprediksi Perdarahan Varises Esofagus Berulang Pada Pasien Sirosis Hati, Andi Cahaya Tahir, Juferdy Kurniawan, Marcellus Simadibrata, Aulia Rizka, Hamzah Shatri, Cosmas Rinaldi A. Lesmana, Nadia Ayu Mulansari

Jurnal Penyakit Dalam Indonesia

Introduction. Esophageal variceal bleeding is one of the complications caused by an increase in pressure within the portal vein blood vessels. The gold standard examination for portal pressure is the hepatic venous pressure gradient (HVPG), but HVPG examination is invasive, involving transjugular catheterization of the hepatic vein. Currently, non-invasive methods for measuring portal hypertension are being developed to predict esophageal varices and esophageal variceal bleeding using spleen stiffness measurements. This study aimed to evaluate the accuracy of spleen stiffness measurement in predicting recurrent esophageal variceal bleeding in patients with liver cirrhosis.

Methods. This study used a retrospective cohort …


Hubungan Tingkat Stres, Kecemasan, Dan Depresi Dengan Konstipasi Fungsional Pada Mahasiswa Kedokteran, Khafifah Z, Wilson Wilson, Agustina Arundina Triharja Tejoyuwono Mar 2024

Hubungan Tingkat Stres, Kecemasan, Dan Depresi Dengan Konstipasi Fungsional Pada Mahasiswa Kedokteran, Khafifah Z, Wilson Wilson, Agustina Arundina Triharja Tejoyuwono

Jurnal Penyakit Dalam Indonesia

Introduction. Stress, anxiety, and depression are factors associated with functional constipation that affect students’ quality of life. Stress, anxiety, and depression are often experienced by first-year medical students, but studies assessing these three variables with functional constipation are still limited.

Methods. This study used a cross-sectional analytical design. Study was carried out in July 2023 involving 88 first-year medical students from the Tanjungpura University Medical Study Program. Analysis of relationship tests was carried out using Kendall’s Tau-B tests.

Results. Most students were in the normal category of stress, anxiety and depression levels, however 21 students were in …


Infark Ventrikel Kanan Dengan Blok Atrioventrikular: Laporan Kasus Dengan Tinjauan Pustaka, Naomi Niari Dalimunthe, Refli Hasan, Herwindo Ahmad, Rahmad Isnanta, T Realsyah, Zainal Safri Mar 2024

Infark Ventrikel Kanan Dengan Blok Atrioventrikular: Laporan Kasus Dengan Tinjauan Pustaka, Naomi Niari Dalimunthe, Refli Hasan, Herwindo Ahmad, Rahmad Isnanta, T Realsyah, Zainal Safri

Jurnal Penyakit Dalam Indonesia

Inferior myocardial infarction is frequently accompanied by right ventricular infarction. This report presents two cases of right ventricular infarction accompanied by hemodynamic disorder and atrioventricular block complications. These patients were diagnosed with right ventricular infarction based on history, clinical presentations, and electrocardiography findings. The management approach for these patients involved optimizing volume and fluid status, using temporary pacemakers, and urgent percutaneous coronary intervention. This report highlights the need to promptly identify right ventricular involvement in inferior myocardial infarction, as the treatment strategies for right ventricular infarction are different from left ventricular infarction.


Faktor-Faktor Yang Memengaruhi Kualitas Hidup Pasien Gagal Jantung Kronik Fraksi Ejeksi Terjaga (Hfpef) Rawat Jalan Di Rsupn Dr. Cipto Mangunkusumo, Derin Anugrah Pratama, Sally Aman Nasution, Muhadi Muhadi, Arif Mansjoer, Idrus Alwi, Dyah Purnamasari, Aida Lydia, Dicky Levenus Tahapary Mar 2024

Faktor-Faktor Yang Memengaruhi Kualitas Hidup Pasien Gagal Jantung Kronik Fraksi Ejeksi Terjaga (Hfpef) Rawat Jalan Di Rsupn Dr. Cipto Mangunkusumo, Derin Anugrah Pratama, Sally Aman Nasution, Muhadi Muhadi, Arif Mansjoer, Idrus Alwi, Dyah Purnamasari, Aida Lydia, Dicky Levenus Tahapary

Jurnal Penyakit Dalam Indonesia

Introduction. The prevalence of heart failure in Indonesian adults is 1.5%, at least half of which categorized as heart failure with preserved ejection fraction (HFpEF). Quality of life assessment plays an important role in the management of heart failure, one of the tools widely used is the Minnesota Living with Heart Failure (MLHF) questionnaire. In Indonesia, there is still no data regarding risk factors that affect the quality of life of HFpEF patients. This study aimed to determine the quality of life profile of HFpEF patients and the relationship between the risk factors (age, hypertension, DM, smoking, and obesity) …


Gambaran Klinis Pasien Terduga Tuberkulosis Paru Resisten Obat (Tb-Ro) Dengan Kolonisasi Candida Sp. Di Rumah Sakit Hasan Sadikin Bandung, Hasna Rafifah Zahira Zalfa, Iceu Dimas Kulsum, Hendarsyah Suryadinata, Chrysanti Chrysanti, Intan Mauli Warma Dewi Mar 2024

Gambaran Klinis Pasien Terduga Tuberkulosis Paru Resisten Obat (Tb-Ro) Dengan Kolonisasi Candida Sp. Di Rumah Sakit Hasan Sadikin Bandung, Hasna Rafifah Zahira Zalfa, Iceu Dimas Kulsum, Hendarsyah Suryadinata, Chrysanti Chrysanti, Intan Mauli Warma Dewi

Jurnal Penyakit Dalam Indonesia

Introduction. Candida sp. is a fungus that lives as a commensal in human body, but may cause infection upon immune suppression. The decrease in immunity due to TB infection and long-term use of antibiotics in TB patients may increase the risk of the Candida sp. colonization in patient. Data regarding the prevalence of Candida sp. colonization in TB patients and its impact has not been widely reported. This study was conducted to determine the prevalence and clinical characteristics of presumptive drug-resistance TB patients with Candida sp. colonization.

Methods. A cross-sectional study was conducted using secondary data from a …


Program Multidisiplin Pasien Gagal Jantung Kronik Untuk Menurunkan Angka Perawatan Ulang Rumah Sakit, Lusiani Lusiani, Nurhayati Adnan Mar 2024

Program Multidisiplin Pasien Gagal Jantung Kronik Untuk Menurunkan Angka Perawatan Ulang Rumah Sakit, Lusiani Lusiani, Nurhayati Adnan

Jurnal Penyakit Dalam Indonesia

Heart failure is a complex disease caused by abnormalities in the structure or function of the heart resulting in decreased cardiac output. The complexity of heart failure causes an increasing burden of mortality and morbidity. This has further exacerbated the burden of treatment costs as well as the high rate of hospital readmissions. Readmission rate in patients with heart failure within 30 days post-hospitalization can reach 17.5%. In order to reduce re-hospitalization rates, multidisciplinary programs were introduced. The program involves collaboration of cardiologists, specialty nurses, pharmacists, nutritionists, and social workers using home or clinic-based models. Studies show that special management …


Etika Publikasi Di Bidang Kedokteran, Chyntia Olivia Murine Jasirwan, Edward Faisal, Evy Yunihastuti Mar 2024

Etika Publikasi Di Bidang Kedokteran, Chyntia Olivia Murine Jasirwan, Edward Faisal, Evy Yunihastuti

Jurnal Penyakit Dalam Indonesia

Publikasi ilmiah merupakan penjelasan sistematis mengenai hipotesis, bukti, dan kesimpulan dari sebuah penelitian yang dimaksudkan untuk mengedukasi masyarakat. Publikasi merupakan tujuan utama dari penelitian, dan peer-review dilakukan untuk memverifikasi temuan dan meningkatkan kepercayaan penulis untuk evaluasi penelitian yang dipublikasi. Publikasi merupakan salah satu persyaratan khusus dalam suatu institusi akademik dan dapat mendukung promosi ke jabatan akademis. Publikasi (nasional dan internasional) telah menjadi norma yang dapat dikatakan wajib dalam dunia pendidikan. Berbagai pelanggaran etika banyak terjadi dan kita temukan, seperti plagiarisme, tata bahasa yang tidak pantas, dan praktik pengelolaan data yang meragukan. Kurangnya pemahaman tentang etika penelitian seringkali menjadi akar dari …


Efektivitas Terapi Antituberkulosis Empirik Pada Pasien Dengan Penyakit Hiv Stadium Lanjut: Sebuah Laporan Kasus Berbasis Bukti, Natasha Chandra, Dina Elita, Evy Yunihastuti Mar 2024

Efektivitas Terapi Antituberkulosis Empirik Pada Pasien Dengan Penyakit Hiv Stadium Lanjut: Sebuah Laporan Kasus Berbasis Bukti, Natasha Chandra, Dina Elita, Evy Yunihastuti

Jurnal Penyakit Dalam Indonesia

Patients with advanced human immunodeficiency virus (HIV) disease have a high risk of mortality, with tuberculosis (TB) being one of the leading causes. Empiric antituberculosis therapy could be considered as a strategy to reduced mortality although there is no strong evidence. This study aims to review the efficacy of empiric antituberculosis therapy in patient with advanced HIV disease compared to isoniazid prophylaxis therapy and assessed with mortality as outcome. A 46- year old male patient with advanced HIV disease on antiretroviral therapy (ARV) and liver cirrhosis was admitted to hospital due to difficulties in sleeping and walking. During hospitalization he …


In Silico Analysis Of C-Type Lectins As Co-Infection Receptors Of Dengue And Chikungunya Viruses In Aedes Aegypti, Munawir Sazali, R. C. Hidayat Soesilohadi, Nastiti Wijayanti, Tri Wibawa, Arif Nur Muhammad Ansori Mar 2024

In Silico Analysis Of C-Type Lectins As Co-Infection Receptors Of Dengue And Chikungunya Viruses In Aedes Aegypti, Munawir Sazali, R. C. Hidayat Soesilohadi, Nastiti Wijayanti, Tri Wibawa, Arif Nur Muhammad Ansori

Makara Journal of Science

Aedes aegypti is a primer vector of dengue virus (DENV) and chikungunya virus (CHIKV). The susceptibility of mosquitoes to DENV and CHIKV depends on their recognition receptor of pathogens. C-type lectins (CTLs) are an important mediator of virus infection in A. aegypti. This study aims to identify potential receptors and determine the binding affinity between ligand–receptor interaction, CTLs and virus envelopes (DENV-1, 2, 3, and 4 and CHIKV) interaction based on in silico analysis. Sample sequences were obtained from GenBank (NCBI), and 10 CTLs were acquired from VectorBase. Homology modeling based on a minimum standard of 20% was processed …


The Effects Of Environmental Noise On Annoyance, Stress, And Urine Cortisol Levels Among Residents Living Near Industrial Sites In Bangkok, Thailand, Nutthajit Onmek, Narisa Kengtrong Bordeerat, Supat Wangwongwatana Feb 2024

The Effects Of Environmental Noise On Annoyance, Stress, And Urine Cortisol Levels Among Residents Living Near Industrial Sites In Bangkok, Thailand, Nutthajit Onmek, Narisa Kengtrong Bordeerat, Supat Wangwongwatana

Kesmas

People are exposed to environmental noise each day. It may be annoying, cause stress, induce hormonal changes, and negatively affect long-term health. This study aimed to determine the effects of environmental noise on annoyance, perceived stress, stress symptoms, and urine cortisol in people living in a selected area. This cross-sectional study was conducted from April to October 2022 on 142 participants. Urine samples were collected to determine cortisol levels, and perceived stress, stress symptoms, and environmental noise annoyance were evaluated using questionnaires. Stress symptoms correlated with traffic, industrial, and community noise, but not aircraft noise. Community noise correlated most strongly …


Road Traffic Noise Annoyance And Cardiovascular Disease Risk In Population: A Case Series Study In Kota Bharu, Malaysia, Faridah Naim, Nurin H M Nasir Feb 2024

Road Traffic Noise Annoyance And Cardiovascular Disease Risk In Population: A Case Series Study In Kota Bharu, Malaysia, Faridah Naim, Nurin H M Nasir

Kesmas

Noise pollution can cause annoyance, significantly threatening the population’s health and well-being. This study aimed to find an association between road traffic noise exposure and cardiovascular disease (CVD) risk among residents in Kota Bharu, Malaysia. This descriptive study used a case series approach and surveyed 34 residents in selected residential areas near main roads. An adapted questionnaire was distributed to residents using a purposive sampling method. Questions related to sociodemographic information, self-reporting about CVD, and road traffic noise assessment were asked to investigate the underlying risk factors for CVD. The average score of CVD assessment was classified as moderate risk. …


Daily Income Targets And Passenger Pressure On Safety Risky Riding Behavior Among Online Motorcycle Taxi Riders In Jakarta, Indonesia, Zulkifli Djunaidi, Agra Mohamad Khaliwa, Azka Hafia, Nadya Putri Feb 2024

Daily Income Targets And Passenger Pressure On Safety Risky Riding Behavior Among Online Motorcycle Taxi Riders In Jakarta, Indonesia, Zulkifli Djunaidi, Agra Mohamad Khaliwa, Azka Hafia, Nadya Putri

Kesmas

Online motorcycle taxi riders, a vulnerable group on the road, are more susceptible to serious injury than non-motorcycle riders. This study analyzed a correlation between daily income targets, passenger pressure, risk perception, safety attitudes, and risky riding behavior. This cross-sectional study used a semi-quantitative approach by collecting online-based questionnaires from 500 online motorcycle taxi riders in Jakarta, and 50 of them were obtained through offline interviews. The findings revealed a significant relationship between daily income targets, passenger pressure, risk perception (danger level, stochastic evaluation, and safety priority), safety attitudes (pragmatic attitude to rule violations and dissatisfaction with traffic rules), and …


The Importance Of Blood Pressure Control In The Survival Of Peritoneal Dialysis Patients Using A Multistate Model, Hadis Najafimehr, Abbas Rahimi Foroushani, Mir Saeed Yekaninejad, Mahmoud Yousefifard, Mostafa Hosseini Feb 2024

The Importance Of Blood Pressure Control In The Survival Of Peritoneal Dialysis Patients Using A Multistate Model, Hadis Najafimehr, Abbas Rahimi Foroushani, Mir Saeed Yekaninejad, Mahmoud Yousefifard, Mostafa Hosseini

Kesmas

Since less attention has been paid to the effect of passing blood pressure states on the survival of peritoneal dialysis (PD) patients, this study aimed to inves­tigate the survival of PD patients with and without hypertension, estimate the probability of hypertension and determine the influential factors. In this retro­spective cohort study, the data of 700 patients visiting dialysis centers from all provinces of Iran from 1997-2009 were analyzed. For data analysis, the multistate survival model was used. The median survival time (months) and five-year survival were 75% and 56%, respectively. Males had a higher probability of hypertension (63%) than females …


Depression Among Islamic Boarding Schools Students During The Covid-19 Pandemic In East Java, Indonesia, Yuni Asri, Dian Pitaloka Priasmoro, Muhammad Solihuddin Muhtar, Yankuba B. Manga Feb 2024

Depression Among Islamic Boarding Schools Students During The Covid-19 Pandemic In East Java, Indonesia, Yuni Asri, Dian Pitaloka Priasmoro, Muhammad Solihuddin Muhtar, Yankuba B. Manga

Kesmas

The COVID-19 pandemic significantly impacts many aspects of life, including health, economy, society, education, and mental well-being. The pandemic impact on mental health, in particular, leads to increased rates of depression, anxiety, and stress. This study aimed to determine the prevalence of depression among Islamic boarding school students in Indonesia and identify factors associated with depression symptoms. This cross-sectional study employed questionnaires for data collection. Assessment of depression levels used the DASS-21 tool. Descriptive statistics and multivariate logistic regression were applied to analyze relationships between variables. The study findings indicated that 62.4% of the students exhibited factors associated with depression. …


Factors Affecting Superoxide Dismutase Activity In Railway Workers In Jakarta, Indonesia, Vera Winata, Muhammad Ilyas, Aria Kekalih, Suryo Wibowo, Muchtaruddin Mansyur Jan 2024

Factors Affecting Superoxide Dismutase Activity In Railway Workers In Jakarta, Indonesia, Vera Winata, Muhammad Ilyas, Aria Kekalih, Suryo Wibowo, Muchtaruddin Mansyur

Occupational and Environmental Medicine Journal of Indonesia

Introduction. Railway workers are exposed to many occupational health risk factors that may cause oxidative stress. Superoxide dismutase (SOD) activity is one of the response biomarkers of oxidative stress.

Methods. A cross-sectional study was conducted from July-October 2021. Eighty-four participants were included in this study. Data about participants’ characteristics, physical activity intensity as measured by the Global Physical Activity Questionnaire (GPAQ) version 2, and stress levels as measured by Holmes-Rahe Stress Inventory were collected using Google Forms. The physical examination yielded data on blood pressure, ear condition, and waist circumference. Blood Superoxide dismutase activity and HbA1c levels were determined using …


The Association Between Mental Workload And Nonspecific Chronic Low Back Pain Among Operators Of An On Shore Oil And Gas Company In South Sumatera, Ardi Artanto, Suryo Wibowo, Nuri Purwito Adi Jan 2024

The Association Between Mental Workload And Nonspecific Chronic Low Back Pain Among Operators Of An On Shore Oil And Gas Company In South Sumatera, Ardi Artanto, Suryo Wibowo, Nuri Purwito Adi

Occupational and Environmental Medicine Journal of Indonesia

Background: Work location influences the proportion of operators with low back pain (LBP) at a South Sumatera onshore oil and gas company. This study aimed to determine the prevalence of nonspecific chronic LBP among the company's operators, as well as the association between quantitative and qualitative mental workload and nonspecific chronic LBP.

Methods: This study was cross-sectional in design, with 96 samples collected through purposive sampling. Questionnaires and physical examinations were used to collect data.

Results: Nonspecific chronic LBP was found in 32.3 percent of people. According to the multivariate analysis, moderate-heavy qualitative mental workload (OR: 5.14; 95 percent CI: …