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Full-Text Articles in Medicine and Health Sciences
Expression Of Cd55 And Cd35 On Red Blood Cells Of Children With Beta-Thalassemia Major, Amira M. F. Shehata, Esraa G. R. Awad, Mahmoud A. El-Hawy, Rawhia H. El-Edel
Expression Of Cd55 And Cd35 On Red Blood Cells Of Children With Beta-Thalassemia Major, Amira M. F. Shehata, Esraa G. R. Awad, Mahmoud A. El-Hawy, Rawhia H. El-Edel
Menoufia Medical Journal
Background Beta-thalassemia is a hereditary disease that is characterized by ineffective erythropoiesis and shortened red blood cell survival. In severe cases, blood transfusion is a mainstay therapy; however, regular blood transfusions result in iron overload with serious complications. Complement-mediated erythrocyte destruction is one of the pathological causes of hemolysis in beta-thalassemia. Membrane-bound complement regulatory proteins such as CD55 and CD35 ensure that the complement system does not become overactivated, thus causing harm to self-tissues. Objectives To assess the expression of CD55 and CD35 on erythrocytes of β-thalassemia patients and its correlation with hemoglobin (Hb) levels and other markers of hemolysis. …
Prevalence And Distribution Of Major -Thalassemia Mutations And Hbe/-Thalassemia Variant In Nepalese Ethnic Groups, Zilfalil Bin Alwi, Raju Lama, Wardah Yusof, Tilak R. Shrestha, Sarifah Hanafi, Matrika Bhattarai, Rosline Hassan, Bin Alwi Zilfalil
Prevalence And Distribution Of Major -Thalassemia Mutations And Hbe/-Thalassemia Variant In Nepalese Ethnic Groups, Zilfalil Bin Alwi, Raju Lama, Wardah Yusof, Tilak R. Shrestha, Sarifah Hanafi, Matrika Bhattarai, Rosline Hassan, Bin Alwi Zilfalil
Hematology/Oncology and Stem Cell Therapy
Background: Beta-thalassemia is a genetic disorder that is inherited in an autosomal recessive pattern. This genetic disease leads to a defective beta-globin hemoglobin chain causing partial or complete beta-globin chain synthesis loss. Beta-thalassemia major patients need a continuous blood transfusion and iron chelation to maintain the normal homeostasis of red blood cells (RBCs) and other systems in the body. Patients also require treatment procedures that are costly and tedious, resulting in a serious health burden for developing nations such as Nepal. Methods: A total of 61 individuals clinically diagnosed to have thalassemia were genotyped with multiplex amplification refractory mutation systemepolymerase …