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Full-Text Articles in Medicine and Health Sciences
Outcome Result Of Acute Myeloid Leukemia Undergoing Treatment In Semi-Isolation Chemotherapy Ward, Cosphiadi Irawan, Ricci Steven, Ralph Girson Gunarsa, Jeffry Bela Tenggara
Outcome Result Of Acute Myeloid Leukemia Undergoing Treatment In Semi-Isolation Chemotherapy Ward, Cosphiadi Irawan, Ricci Steven, Ralph Girson Gunarsa, Jeffry Bela Tenggara
Jurnal Penyakit Dalam Indonesia
Introduction. Standard positive pressure isolation room is not yet widely available in Indonesia. In several private hospitals, current best practice is admitting patients to semi-isolation room with additional protective measures. Despite the limitation, this practice is considered safe and might benefit Acute Myeloid Leukemia (AML) patients. This study aimed to analyze the leukemic profile and survival in AML patients admitted to semi-isolation room. Methods. A retrospective cohort study was conducted using secondary data from medical record of AML patients diagnosed in Mochtar Riady Comprehensive Cancer Center between 2018 – 2020. Patients were divided into semi-isolation room group and not admitted …
Adoptive Cellular Therapy In Acute Myeloid Leukemia: Current Scope And Challenges, Sankalp Arora, Palash Asawa, Aravind Ramakrishnan, Carlos Bachier, Navneet S Majhail
Adoptive Cellular Therapy In Acute Myeloid Leukemia: Current Scope And Challenges, Sankalp Arora, Palash Asawa, Aravind Ramakrishnan, Carlos Bachier, Navneet S Majhail
Hematology/Oncology and Stem Cell Therapy
Adoptive cellular therapies have revolutionized the management of hematologic malignancies, particularly lymphoma and multiple myeloma. These novel therapies targeting disease specific antigens such as CD19 in lymphoma and B cell maturation antigen in multiple myeloma have been shown to be efficacious and reasonably well tolerated, especially when compared to conventional chemotherapies. Unfortunately, their potential has not been realized in acute myeloid leukemia (AML). This can be attributed to the fact that most targetable antigens on AML cells are also expressed on healthy myeloid hematopoietic stem cells (HSC); targeting them results in severe myeloablative effects and pancytopenia. Over the years, several …