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Full-Text Articles in Medicine and Health Sciences
Biological Therapy In The Treatment Of Melanoma, Simona Roxana Georgescu, Mihaela Roxana Ioghen, Maria Isabela Sarbu, Alexandra-Florentina Ion, Ela Ghita, Cristina-Iulia Mitran, Madalina-Irina Mitran, Vasile Benea, Mircea Tampa
Biological Therapy In The Treatment Of Melanoma, Simona Roxana Georgescu, Mihaela Roxana Ioghen, Maria Isabela Sarbu, Alexandra-Florentina Ion, Ela Ghita, Cristina-Iulia Mitran, Madalina-Irina Mitran, Vasile Benea, Mircea Tampa
Journal of Mind and Medical Sciences
Melanoma is one of the most aggressive tumors and its incidence is on the rise. The low rates of survival in metastatic melanoma has led to the development of new drugs for this type of patient, such as biological therapy which has shown remarkable results. This therapy is based on stimulation of the immune system to fight tumoral cells through: injection of cytokines with immunomodulatory properties (interleukin-2, alpha-interferon), vaccination with tumor antigens or immune cells that process tumor antigens, adoptive immunotherapy, inhibition of immune checkpoints (PD-1, CTLA-4), inhibition or stimulation of immune modulator molecules (OX-40, LAG-3), inhibition of signaling pathways …
Myeloma Immunotherapy, Alaa E. Abdelhamid, Amira M. Elmasry, Mohammad A. Abdelhafez, Sabry A. Shoieb
Myeloma Immunotherapy, Alaa E. Abdelhamid, Amira M. Elmasry, Mohammad A. Abdelhafez, Sabry A. Shoieb
Menoufia Medical Journal
The objective of this study was to review the role of immunotherapy in treating multiple myeloma (MM). Medline databases (PubMed, Medscape, and ScienceDirect) and all related materials available on the internet from January 1993 to December 2016 were searched. The initial search presented 90 articles of which 29 met inclusion criteria. The articles studied the role of immunotherapy in treating MM. If the studies did not fulfi ll inclusion criteria, they were excluded. Study quality assessment included whether ethics approval was gained, eligibility criteria were specifi ed, appropriate controls were used, adequate information was provided, and whether defi ned assessment …
Evaluation Of Biological Response Modification And Immunotherapeutic Activities Of Barley-Derived Arabinoxylans Against Coccidiosis In Commercial Broilers, Masood Akhtar, Muteen Humayun, Zafar Iqbal, Mian Muhammad Awais, Muhammad Irfan Anwar
Evaluation Of Biological Response Modification And Immunotherapeutic Activities Of Barley-Derived Arabinoxylans Against Coccidiosis In Commercial Broilers, Masood Akhtar, Muteen Humayun, Zafar Iqbal, Mian Muhammad Awais, Muhammad Irfan Anwar
Turkish Journal of Veterinary & Animal Sciences
Plant-derived polysaccharides have been reported for diverse biological response modification (BRM) and immunotherapeutic (IT) activities in animals by activating their defense systems to perform better immunogenically against invading pathogens. Keeping this in view, this study was conducted to assess the BRM and IT activities of barley (Hordeum vulgare L.)-derived arabinoxylans (AXs) against coccidiosis in broilers. Significantly enhanced (P < 0.05) in vivo and in vitro lymphoproliferative responses to T-cell mitogens were revealed in broilers administered barley AXs when compared to the control group. Humoral immune response in terms of antibody titers against sheep erythrocytes was also found higher (P < 0.05) in AX-administered chickens. Furthermore, AX-administered chickens also showed higher weekly weight gains and improved feed conversion ratios as compared to controls. Results of the challenge experiment showed that the percentage of protection and daily weight gains were statistically higher (P < 0.05) whereas mean oocysts per gram of droppings and lesion scores were significantly lower (P < 0.05) in the chickens administered barley AXs as compared to controls. In conclusion, barley-derived AXs led to better growth performance and elicited humoral and cellular immune responses in commercial broilers that persisted against coccidial infection in broiler chickens.