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Full-Text Articles in Medicine and Health Sciences
Assessment Of T-Regulatory Cells In Type 1 Diabetes Mellitus, Rawhia H. El-Edel, Samar M. Kamal Eldein, Samar S. Salman, Wafaa M. Abo El Fotoh
Assessment Of T-Regulatory Cells In Type 1 Diabetes Mellitus, Rawhia H. El-Edel, Samar M. Kamal Eldein, Samar S. Salman, Wafaa M. Abo El Fotoh
Menoufia Medical Journal
Objective The aim of the study was to evaluate T-regulatory cells (Tregs) expression in the peripheral blood of children with type 1 diabetes mellitus (T1D). Background T1D is mainly a T-cell-mediated autoimmune disease characterized by the destruction of pancreatic β cells leading to insulin deficiency. It is a common autoimmune disorder in childhood, but the disease may become manifest at any age, even in adults. Tregs are subsets of T cells that have an essential role in maintaining tolerance; thus, these cells may play an important role in the pathogenesis of T1D. Patients and methods This study was carried out …
Chemical Modulation Of Cancer Cells To Enhance Tumor Immunity, Florisela Herrejon Chavez
Chemical Modulation Of Cancer Cells To Enhance Tumor Immunity, Florisela Herrejon Chavez
PSU McNair Scholars Online Journal
Breakthroughs in immunotherapy have led to cancer therapeutics that activate the immune system by blocking inhibitory mechanisms. This class of therapeutics has resulted in longer survival rates for cancer patients, some living over 10 years after being diagnosed as terminally ill. However, only a small fraction of patients who receive immunotherapy drugs respond favorably.Recent studies suggest that certain anticancer agents (both cytotoxic chemotherapeutics and targeted drugs) stimulate immune recognition of cancers. Identification of such immunomodulatory anticancer agents would make ideal partners for current immunotherapy treatments, thus increasing the proportion of the treated patients who benefit from immunotherapy. This study aimed …