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Inactivation Of Picornaviruses And Caliciviruses; Part 2: Inactivation, Suphachai Nuanualsuwan, Dean O. Cliver
Inactivation Of Picornaviruses And Caliciviruses; Part 2: Inactivation, Suphachai Nuanualsuwan, Dean O. Cliver
The Thai Journal of Veterinary Medicine
The prevention of human fecal contamination of food and water is an effective measure to control the transmission of foodborne disease viruses e.g. hepatitis A virus (HAV) and calicivirus found in food chains and water systems. If the prevention of virus contamination is not successful, one of the most common critical control points in the food industry is the inactivation of viruses that contaminate the food or water. The objective of inactivation is to modify the virus or make it abort in the next replicative cycle. The efficiency of inactivating agents is measured by the plots of "logarithmic scale of …
Inactivation Of Picornaviruses And Caliciviruses Part 1: Biology And Epidemiology, Suphachai Nuanualsuwan, Dean O. Cliver
Inactivation Of Picornaviruses And Caliciviruses Part 1: Biology And Epidemiology, Suphachai Nuanualsuwan, Dean O. Cliver
The Thai Journal of Veterinary Medicine
Foodborne picornaviruses and human calicivirus have one molecule of linear, positive-sense, single-stranded RNA, covered by a capsid without a lipid envelope. These viruses have a spherical shape, a particle diameter of 27-40 nanometers and the triangulation (T=3) icosahedral symmetry of a capsid. The replication cycle of poliovirus (PV) and hepatitis A virus (HAV) occurs in the cytoplasm of the host cell. The viral proteins are synthesized by the translation of RNA after the virus particles attach and uncoat at the host cell membrane. Major translated proteins are structural protein (capsid protein) and functional proteins e.g. proteases and RNAdependent RNA polymerase. …