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Taiwan Academy of Physical Medicine and Rehabilitation
脊髓損傷;類固醇;神經恢復;spinal cord injury;steroid;neurological recovery
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Full-Text Articles in Medicine and Health Sciences
Pharmacotherapy In Acute Spinal Cord Injury, Yen-Ho Wang, Tien-Shang Huang
Pharmacotherapy In Acute Spinal Cord Injury, Yen-Ho Wang, Tien-Shang Huang
Rehabilitation Practice and Science
Acute traumatic spinal cord injury (SCI), a devastating event, results in huge costs to patients and society. Current management emphasizes general supportive care and stabilization of associated spinal columnar injury to prevent worsening of the cord lesions. Most of the numerous experimental studies to investigate pathophysiological changes following acute SCI suggest a two-step mechanism of damage to the spinal cord in which the primary (direct) or mechanical injury caused by trauma initiates secondary (indirect) or progressive autodestructive injury of the cord. During recent years, free oxygen radical generation and lipid peroxidation have been implicated in the secondary injury.Several pharmacological agents …