Medicine and Health Sciences Commons^™

Binding Pocket Identification And Determination Of Overlapping With Different Software Tools For V8 Protease (1qy6) From Staphylococcus Aureus, Faranak Nadarkhani Dinehkaboudi, Nadimbhai Salimbhai Vahora, Ra'ed Khashan

Discovery Day

Background:

Protein-ligand interactions are critical for biochemical functionality in living organisms, and determining the binding pocket characteristics of a protein is essential for designing drugs that interact with specific protein pockets. Several software tools, such as Deepsite, FTSite, CASTp, and F pocket, are available for identifying these binding pockets.

Objective:

This study aimed to determine the percentage overlap and identify the best binding pocket of V8 Protease (1QY6) from Staphylococcus aureus using different software tools.

Method:

The study retrieved the protease protein's PDB file from the Protein Data Bank and used software programs such as Deepsite, CASTp, and FTsite to …

The Impact Of Online Education On Families During Covid-19, Meghal Shah, Duaa Zahid, Heather Butts

Discovery Day

In the year 2020, the whole world was hit by a pandemic name COVID-19. It resulted in school closures across the world, which has impacted millions of children’s education. As a result, education has transitioned online via digital platforms. For many families, these transformations to online education have been difficult. For low-income families, people couldn’t afford or may not have had access to supplies needed for online education like high-speed internet and a computer. National Education Association (NEA) reports that 13.5 million children aged 5-7 years have no access to these technologies. It can be difficult for parents to understand …

Intranasal Sufentail Vs. Intravenous Morphine For Acute Pain In The Emergency Department, Billy Sin, Lilia Davenport, Gabriella Sikorska, Joi Yam Yau Lin

Discovery Day

Introduction: Acute pain management in the emergency department (ED) requires prompt administration of safe and effective analgesia. ¬Traditional routes of administration for analgesia includes the oral (PO), intravenous (IV), or intramuscular routes (IM). When these routes of administration are not feasible, the intranasal (IN) route may be considered. Furthermore, a rapid onset of therapeutic effects may be observed due to the rich capillary network of the respiratory mucosa that is able to promptly transport the drug into systemic circulation. There is emerging literature that supports the use of analgesia via the IN route in the Emergency Department (ED). However, its …

Effects On Slp Graduate Students’ Clinical Skills Following “Case Study Nights”, George Pagano, Carmine Lacertosa, Fred Stal

Discovery Day

This poster describes the evolution of graduate students in their clinical knowledge and attitudes before and after participating in case study nights. Speech- Language Pathology students from Long Island University (LIU) -Brooklyn had the opportunity to observe a professional describe various clinical etiologies, assessments, and treatments coupled with a client presentation during two semesters. Student evaluations measured clinician’s outcome with respect to service delivery and treatment approaches when working with multiple clients with communication disorders.

Are We Ready For This?: Students’ Introspection On Clinical Preparedness, George Pagano, Lauren Sher, Caroline Woods

Discovery Day

This poster describes graduate student clinicians' self-assessment of preparedness for off-campus pediatric and adult externships in speech-language pathology by examining the reported positive components as well as perceived areas of development in their graduate-level preparation. The subsequent feedback has implications for enhancing the clinical preparation aspect of speech-language pathology graduate programs.

How To Stop Killing Patients With Healthcare-Associated Infections, Ann Bernstein, Emily Demino, Jonathan Eng, Peter Forman

Discovery Day

Background. Healthcare-associated infections (HAIs), also known as nosocomial infections, are a significant cause of preventable death for patients receiving treatment for medical or surgical conditions. HAIs are attributed to 99,000 patient deaths in the United States annually. These infections rack up an estimated $20 billion of additional costs per year by extending the length of stay for hospitalized patients and increasing the cost of treatment at the same time. Current empirical findings highlight the severity and gravity of the effect that HAIs have on patient communities around the world.

Methodology. The Google Scholar search engine was utilized with the search …

Tick-Talk: Human Babesiosis, Brieanne Bieber, Angelica Giuliani, Hannah Palochak

Discovery Day

Background: Human babesiosis is a parasitic infection caused by species of the protozoan Babesia, most commonly B. microti. The organism invades the erythrocytes causing them to lyse. The infection is transmitted through the Ixodes tick, which is commonly found on white mice and white tailed deer. Outbreaks of this disease most commonly occur in the Northeastern region of the United States, specifically New England and Long Island, New York, during spring and summer months, due to the greater proximity of vectors to humans. Patients who are infected can have a range of symptoms from asymptomatic to severe manifestations, including …

Prescription Drug Abuse, Matthew Barlow, Chloe Connolly, Tim Godfrey, Jenna Plean

Discovery Day

Background. In the United States, the leading cause of injury death is from prescription drug overdose. The most commonly abused prescription medications are (a) pain relievers (opioids), (b) CNS depressants (tranquilizers, sedatives, hypnotics), and (c) stimulants. Opioids are a class of drugs that includes both heroin and prescription pain relievers. CNS depressants are for managing anxiety and stimulates are used in ADHD. A consequence of abuse is drug overdose death, with opioids being the leading cause. Opioids are safe for short term use but have a strong potential to be abused resulting in addiction. In order to understand this …

All Shook Up: A Review Of Sport-Related Concussions In High School Athletes, Daniel Mclaren, Kevin O’Connell, Matthew Paparella, Nicholas Petito

Discovery Day

Background: Concussions comprise 24.8% of the total injuries in high school athletes, putting developing brains at risk for neurocognitive dysfunction. Recent research has been geared towards finding the most effective process for (a) diagnosing, (b) treating and (c) preventing concussions. The most recent data from the Centers for Disease Control and Prevention (CDC) show that 329,290 children were diagnosed with a sports related concussion or traumatic brain injury (TBI) in 2012.

Methods: A systematic review of current literature was performed using the Long Island University online library database and Google Scholar. Search terms included: (a) concussion, (b) sports, (c) high …

Teen Pregnancy, Carly Anderson, Brianna Fuessler, Anna Forgach, Holly Stumpf

Discovery Day

Background. In 2015, more than 200,000 babies were born to women aged 15-19, a record low for teens in the United States. However, it remains substantially higher than in other western industrialized nations. The highest rates of teen pregnancy occur in the rural areas of the Southern states. Black and Hispanic teens are more than twice as likely as White teens to become pregnant. Factors that contribute to teen pregnancy include (a) low socioeconomic conditions, (b) lower education, (c) low income levels, (d) decreased healthcare access, and (e) being on welfare. The U.S. government has been working to combat these …

Domestic Violence, Kevin Berardi, Ashley John, Ryan Moran, Steph Perella

Discovery Day

Background. Domestic violence, intimate partner violence (IPV), or domestic abuse, is defined as a pattern of behaviors used by one partner to maintain power and control over another partner in an intimate relationship. These behaviors include physical acts and nonphysical acts, including using (a) intimidation, (b) coercion, (c) threats, (d) isolation, and (e) finances to maintain power. Domestic abuse occurs regardless of (a) race, (b) gender, (c) age, (d) sexual orientation, and (e) socioeconomic status. The immediate effects of domestic violence manifest in the form of physical injuries, including (a) cuts, (b) bruises, (c) bitemarks, (d) concussions, and (e) …

Have You Checked Your Skin Late?, Kristina Mortzfield, Jordan Clark, Lia Disciascio, Mary Lynam

Discovery Day

Background. Skin cancer, while preventable, is diagnosed in 20% of Americans. All populations are susceptible, but factors that increase risk of development include: (a) male gender, (b) fair skin, (c) aging, (d) personal history of UV radiation exposure, and (e) previous history of skin cancer. Non-melanoma types, basal cell carcinoma and squamous cell carcinoma, have a lower risk of metastasis while melanoma, if not detected early, can result in distant and fatal metastasis.

Methods. A review of the literature was completed using Google. The terms searched included: (a) skin cancer risk factors, (b) skin cancer prevention, (c) skin cancer screening. …

Pica: The Mysterious Eating Disorder, James Ferrante, Justin Fisher, Tara Sung, Spencer Wenzel

Discovery Day

Background. ‘Pica’ is the Latin word for magpie, a bird that ingests inedible substances. The DSM-V defines pica as a disorder of persistent eating of nonnutritive, nonfood substances over a period of at least one month. Although pica is a disorder that affects a widespread population, it is seen as a social anomaly which prevents patients from admitting their behavior. As the behavior continues unnoticed and untreated, patients will experience the adverse effects of ingesting foreign materials. Thus, healthcare providers and family members should educate themselves on pica’s etiologies and manifestations to prevent complications and avoid unnecessary hospitalizations.

Methods. …

Postpartum Depression, Danny Masterson, Christina Butigian, Arlinda Kubati, Emily Ramdeholl, Leticia Sanchez

Discovery Day

Background: Postpartum depression (PPD) affects 10-20% of women in the US. It is a condition in which mothers’ experience depression during pregnancy or within 4 weeks postpartum. Numerous physiological, socio-economic, and psychological factors have been linked to postpartum depression. Mothers with postpartum depression can experience feelings of (a) extreme sadness, (b) anxiety, and (c) exhaustion that may make it difficult for them to complete activities of daily living for themselves or for others. PPD in its severest form can lead to suicide and acts of harming the newborn.

Methodology: Information was gathered using the search engines: (a) Pubmed, (b) PubMed …