Medicine and Health Sciences Commons^™

Scaling-Up, Justine A. Dryburgh

Undergraduate Student Research Internships Conference

Research outputs for Justine Dryburgh's USRI 2021.

Changes In Children's And Parents' Physical Activity Levels During The Covid-19 Pandemic: A Literature Review, Kshitija Mundle

Undergraduate Student Research Internships Conference

Objectives: The purpose of this literature review was to gain an understanding of the impact that the COVID-19 pandemic and associated closures have had on the physical activity levels of children (ages 0-12) and their parents/guardians.

Methods: To identify relevant literature, a comprehensive database search was conducted. Specifically, studies including keywords: parents, children, physical activity, and COVID-19 and their related terms published between March 2020 and August 2021 were screened for inclusion.

Results: A number of articles have been published which suggest that structured/organized physical activities and team play opportunities have decreased during COVID-19 restrictions, while home-based unstructured play and …

Effect Of Carbon Monoxide Releasing Molecule 3 (Corm - 3) On Platelet Adhesion To Human Brain Microvascular Endothelial Cells, Najat S. El-Farra

Undergraduate Student Research Internships Conference

Sepsis is characterized by the widespread inflammation of the body. Systemic inflammation activates and recruits inflammatory cells (e.g., leukocytes) and platelets to the affected organs.

During these inflammatory conditions, human brain microvascular endothelial cells (hBMEC) and platelets both upregulate adhesive molecules rendering platelets to adhere to hBMEC.

Although carbon monoxide is thought of as a toxic molecule to many, previous work shows its anti-inflammatory properties. Evidence has shown carbon monoxide-releasing molecules (e.g., CORM-3; that release small, non-toxic amounts of CO) can combat the effects of severe inflammation in several in vivo animal model.

In this current study, we are looking …

The Influence Of The Social Determinants Of Health On Para-Sports Involvement Throughout The Caribbean And Americas, Laura Misener

Undergraduate Student Research Internships Conference

As the number of individuals with a disability grows worldwide, the Paralympic Games and para-sports have seen a growth in participation (WHO, 2011). However, international sporting competitions including the Paralympic Games remain dominated by developed countries (Andreff, 2001). In the last Paralympic Games, the USA, Canada, and Brazil made up nearly 70% of participants from the North and South American region with 17 of the 28 committees sending five or less participants (Maleske & Sant, 2020). The present study investigates the social and cultural determinants in the Caribbean and Americas of para-sport participation in the region and their relation to …

The Role Of Pannexin 3 In Forced Exercise Bone Remodelling And Its Potential Implications For Osteoarthritis, Justin Tang

Undergraduate Student Research Internships Conference

Exercise such as running has been hypothesized to be a factor of osteoarthritis development. However, the relationship is unclear as differences in genetic backgrounds may influence the risk of osteoarthritis (OA). The gene Panx3 codes for the Pannexin 3 protein (PANX3), a mechanically sensitive channel that allows for the passage of various signalling molecules in both chondrocytes and osteoblasts (Boassa et al., 2007; Penuela et al., 2013; Zhang et al., 2021). We have previously shown PANX3 to be protective in traumatic osteoarthritis, however beneficial in age-induced osteoarthritis (Moon et al., 2021), suggesting that PANX3’s role in osteoarthritis development …

Understanding The Role Of Rhamm In Tumor Load– Mediated Tumor Invasiveness Of Triple Negative Breast Cancer, Ashwin Sritharan, Britney Messam

Undergraduate Student Research Internships Conference

1.Compare the levels of proliferation between RHAMM+/+ and RHAMM -/- MDA-MB-231 spheroids as determined by ki67 and Caspase 3 signaling 2.Compare levels of RHAMM, CD44, Has2, and p-ERK activation between RHAMM+/+ and RHAMM -/- MDA-MB-231 spheroids

The Effect Of Sprint Interval Training And Intermittent Fasting On Cognitive Function, Dana Taghaddos

Undergraduate Student Research Internships Conference

This study will explore how a combination of a time-restricted eating (TRE) strategy and a sprint interval training (SIT) exercise program will affect cognitive function. Both TRE and SIT are easily implemented lifestyle habits that have been shown to present significant brain challenges. Participants will be randomized into 3 groups: either SIT + TRE (Group 1), SIT alone (Group 2), or TRE alone (Group 3). We will assess acute effects (single day of TRE, followed by a single session of SIT the next day), and the effects over a 6 week period. The SIT protocol consists of four 30 second …