Medicine and Health Sciences Commons^™

Evaluating The Effect Of Skipping Ticagrelor Doses And Need For Bolus Doses Upon Treatment Resumption Through Population Pk/Pd Simulation, Hiroyoshi Matsui, Le Thien Truc Pham, Eyob D. Adane

ONU Student Research Colloquium

Ticagrelor (Brilinta (R)) is the first reversibly binding oral P2Y12 receptor antagonist. It is used, mostly in combination with aspirin, in patients with acute coronary syndromes to reduce thrombosis. The manufacturer of ticagrelor recommends discontinuing it at least 5 days before any surgery when possible. While the effect of dose interruptions on the risk of thrombosis is not directly studied, it is important to understand the impact of skipping doses on ticagrelor's PK/PD profile for clinical-decision making. The objectives of the current study were to simulate the impact of therapy interruption on the PK/PD of ticagrelor and examine the need …

Pharmacokinetic/Pharmacodynamic Modeling And Simulation Of Various Bolus And Infusion Doses Of Cangrelor, Le Thien Truc Pham, Eyob Adane

ONU Student Research Colloquium

Background: Cangrelor (Kengreal(R) is a non-thienopyridine parenteral antiplatelet drug approved as an adjunct for the reduction of periprocedural myocardial infarction and stent thrombosis risk in patients undergoing percutaneous coronary intervention (PCI). It is also used off-label for bridging in patients who are off their antiplatelet agents prior to surgery. Cangrelor blocks the binding of adenosine diphosphate (ADP) by reversibly binding to P2Y12 receptors on platelet surfaces. In comparison to other P2Y12 antagonists, cangrelor has a rapidly reversible platelet inhibition effect with a short half-life of approximately 3-5 minutes. Data on simultaneous PK/PD modeling of cangrelor are, however, lacking. The aims …

Psilocybin Prevents Symptoms Of Hyperarousal And Enhances Novel Object Recognition In Rats Exposed To The Single Prolonged Stress Paradigm, Colin R. Del Valle, Heather R. Sparkman, Margaret M. Naylor, Connor M. Cruea, Rachel E. Rice, Claire E. Miller, Brooke E. Bramlage, Lillianna P. Puppel, Madison L. Brown, Aleece K. Al-Olimat, Elizabeth S. Dietz, Phillip R. Zoladz

ONU Student Research Colloquium

Pharmacotherapy for stress-related psychological disorders remains inadequate. Patients who are treated with conventional pharmacological agents frequently report negligeable symptom reduction, and, in most cases, less than 50% experience full remission. Clearly, there is a need for additional pharmaceutical research into both established and novel approaches to alleviate these conditions. Over the past several years, there has been a renewed interest in the use of psychedelics to aid in the treatment of psychological disorders. Several studies have reported promising results in patients with major depression, anxiety disorders, and post-traumatic stress disorder (PTSD) following treatment with psychedelic agents such as lysergic acid …

Low-Dose Psilocybin Enhances Novel Object Recognition But Not Inhibitory Avoidance In Adult Rats, Claire E. Miller, Colin R. Del Valle, Margaret M. Naylor, Heather R. Sparkman, Connor M. Cruea, Rachel E. Rice, Brooke E. Bramlage, Lillianna P. Puppel, Madison L. Brown, Aleece K. Al-Olimat, Elizabeth S. Dietz, Phillip R. Zoladz

ONU Student Research Colloquium

Given the recently renewed interest in using psychedelics to aid in the treatment of psychological disorders, we aimed to examine the impact of psilocybin, a 5-HT_2A agonist, on learning and memory in rodents. Previous work has demonstrated that psilocybin and other 5-HT_2A agonists can enhance fear conditioning, fear extinction, and novel object recognition (NOR). Thus, we predicted that low doses of psilocybin would enhance inhibitory avoidance (IA) and NOR memory. In the first experiment, adult male and female Sprague-Dawley rats underwent step-through IA training (involving 0.45, 0.65, or 1 mA scrambled footshock) and were injected intraperitoneally (i.p.) with …

Combating Long-Term Care Isolation Through Healing Touch, Veronica J. Butts

ONU Student Research Colloquium

Loneliness is defined as feelings of disconnectedness, lack of belonging, and perceived isolation that can manifest as a physical or psychological state. In long-term care facilities, this sentiment can develop into social isolation in which residents are disconnected from family, removed from familiar environments, and suffer from various cognitive conditions that cause them to socially withdraw. Various clinical studies seek to identify the connection between isolation, loneliness, and lack of human touch with worsening health conditions and outcomes, determining that there is a correlation between this feeling of discontent. To combat this, healing touch has been a rising topic of …

Utilizing Evidence-Based Resources For Collaborative Falls Prevention, Kristyn Elise Catrine

ONU Student Research Colloquium

More than 25% of seniors will fall each year due to modifiable and nonmodifiable risk factors. The result is three million emergency department visits and 50 billion dollars in annual healthcare costs.1 Effective falls prevention is complex and needs collaboration from all members of the healthcare team. The best national, state and local strategies individualize patient safety from all sources of harm.2 Multifactorial interventions use health and mobility reviews to reduce the rate of falls and educate older adults.3 The CDC’s Stopping Elderly Accidents, Deaths and Injuries (STEADI) and ASCP/NCOA’s Falls Risk Reduction Toolkit are examples of national programs that …

Pharmacists Provision Of Non-Dispensing Services In Health Professional Shortage Areas, Haley L. Kessinger, Emily R. Landis

ONU Student Research Colloquium

Background: Individuals living in primary care health professional shortage areas (PCHPSAs) experience health inequities. Community pharmacists are healthcare professionals with an opportunity to provide care to underserved populations. The objective of this study was to compare non-dispensing services provided by Ohio community pharmacists in PCHPSAs and non-PCHSPAs.

Methods: An electronic, IRB-approved 19-item survey was sent to all community pharmacists practicing in full PCHPSA counties and a random sample practicing in non-PCHPSA counties in Ohio (n=324). Questions assessed current provision of non-dispensing services as well as interest and barriers regarding such services.

Results: Seventy-three usable responses were received (23% response rate). …

Student Self-Developed Wellness Goals Before And During Covid, Han Pham, Dalen Foster

ONU Student Research Colloquium

Background: This study aims to investigate the change over time in student developed well-being related goals based on the definition of “The 8 dimensions of wellness”. It is expected that the changes experienced by students during the COVID 19 pandemic will impact the type of wellness goals students develop for themselves.

Method: All pharmacy students at ONU are required to complete an annual goal setting assignment as part of their co-curricular requirement each academic year. Personal goals were extracted from submissions from 2019 to 2021. The goals were classified into 8 categories (emotional, financial, intellectual, occupational, physical, social, spiritual, and …

Cinnamon Extract Alters Mcf7 Cell Morphology, Madison M. Anderson

ONU Student Research Colloquium

Cancer prevention is one area of research that has gained interest in recent years. The anti-cancer effects of polyphenols and other nutraceuticals show great promise in prevention as well as therapeutics. In cancers that occur due to epigenetic modifications, molecules that provide these modifications are useful for both the prevention and reversal of disease. Our lab studies the effects of cinnamon extract on cell viability, growth and morphology. Cinnamon extract has high polyphenolic content and is believed to regulate a variety of transcription factors as well as epigenetic modifications. Our observations suggest that a significant change in morphology occurs in …

Improving Cough And Cold Otc Medication Use For Children In Hardin County, Kelly M. Kern, Molly Lipson

ONU Student Research Colloquium

Background: Ohio struggles with high infant mortality rates. This project was designed to combat incorrect use of cough and cold over-the-counter (OTC) medications. Parents or caregivers, especially those with low health literacy, often use these medications incorrectly in infants, sometimes leading to a fatal outcome.

Methods: Utilizing a three-pronged approach, this IRB-approved project addresses the issue of incorrect cough and cold OTC medications use for infants in Hardin County. Passive education was provided to community members via social media/flyers, educational interventions were performed with community members (virtual or in-person), and continuing professional development (CPD) was provided to pharmacists and pharmacy …

Honors Capstone: Healthcare Disparities In Pharmacy Curriculum, Molly Ryan

ONU Student Research Colloquium

Due to the prevalence of disparities within the United States healthcare system, this Honors Program Pharmacy Capstone project is filling the opportunity to enhance the curriculum. The project is focused on improving the educational opportunities for the Raabe College of Pharmacy related to health disparities relevant to the profession of pharmacy. This information will include the history of healthcare abuses to minority groups throughout United States history. The American Association of Colleges of Pharmacy includes academic goals for pharmacy curricula regarding health disparities. The pharmacy accreditation body (ACPE) sets standards that include educating student pharmacists about health disparities. Congruent with …

Classification Of Student Developed Annual Goals, Han Pham, John Mullin

ONU Student Research Colloquium

Objective: This study categorizes goals (personal vs professional and long vs short-term) of student pharmacists. An increase in the proportion of long-term, professional goals is expected as students advance through the program.

Methods: Annual student goals were classified into categories (personal vs professional and long vs short term). Definitions were developed and a beta-test was conducted to confirm interpretations were consistent between raters. Multiple one-tail Z-tests with Bonferroni correction were used to compare the proportion of personal/professional and short-term/long-term goals for P1 students to the proportion of each of the classes of P2-P5 for the years of 2018 and 2019, …

Gauging Interest In An Elective Course To Further Careers In Healthcare Academia, Karielle Shaffery

ONU Student Research Colloquium

There has been continuous growth in the number of pharmacy schools, which has led to an expanded need for pharmacy faculty members. Although there is a recognized and unmet need for such faculty, the topic of pharmacy academia is sparsely addressed in pharmacy programs. Integrating students in an elective teaching course during their didactic education, prior to determination of their career path, could inspire more students to take on the role of an educator. Ideally, allowing students to have first-hand experience in academia focused activities and exposing them to the responsibilities of an academician could peak interest in this area. …

Annual Evaluation Of The Student's Perception Of The Value Of Writing Goals, Renee Kuess

ONU Student Research Colloquium

Focus: This study focused on pharmacy students’ perception of the value of writing goals and how this perception changes as students progress in the program.

Methods: Annually, all students in the pharmacy program are required to reflect on the previous year’s goals and develop new goals. Following this assignment, a survey was sent out to a random sample (n=162) of students. Based on the feedback, the response was classified as indicating “value” or “no value”.

Results: Of the 162 surveys sent out, there were 78 completed responses. 56.25% of responses indicated the student found “value” in the assignment. The data …