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Full-Text Articles in Medicine and Health Sciences
Distinct Neurobehavioural Effects Of Cannabidiol In Transmembrane Domain Neuregulin 1 Mutant Mice, Leonora E. Long, Rose Chesworth, Xu-Feng Huang, Alexander Wong, Adena Spiro, Iain S. Mcgregor, Jonathon Arnold, Tim Karl
Distinct Neurobehavioural Effects Of Cannabidiol In Transmembrane Domain Neuregulin 1 Mutant Mice, Leonora E. Long, Rose Chesworth, Xu-Feng Huang, Alexander Wong, Adena Spiro, Iain S. Mcgregor, Jonathon Arnold, Tim Karl
Xu-Feng Huang
The cannabis constituent cannabidiol (CBD) possesses anxiolytic and antipsychotic properties. We have previously shown that transmembrane domain neuregulin 1 mutant (Nrg1 TM HET) mice display altered neurobehavioural responses to the main psychoactive constituent of cannabis, D9-tetrahydrocannabinol. Here we investigated whether Nrg1 TM HET mice respond differently to CBD and whether CBD reverses schizophrenia-related phenotypes expressed by these mice. Adult male Nrg1 TM HET and wild type-like littermates (WT) received vehicle or CBD (1, 50 or 100 mg/kg i.p.) for 21 days. During treatment and 48 h after withdrawal we measured behaviour, whole blood CBD concentrations and autoradiographic receptor binding. Nrg1 …
Diet High In Oat Β-Glucan Activates The Gut-Hypothalamic (Pyy3-36-Npy) Axis And Increases Satiety In Diet-Induced Obesity In Mice, Xu-Feng Huang, Yinghua Yu, Eleanor Beck, Timothy South, Yulin Li, Marijka Batterham, Linda Tapsell, Jiezhong Chen
Diet High In Oat Β-Glucan Activates The Gut-Hypothalamic (Pyy3-36-Npy) Axis And Increases Satiety In Diet-Induced Obesity In Mice, Xu-Feng Huang, Yinghua Yu, Eleanor Beck, Timothy South, Yulin Li, Marijka Batterham, Linda Tapsell, Jiezhong Chen
Xu-Feng Huang
This study tested the effects of (1-3),(1-4) b-D-glucan from oats, on activation of the guthypothalamic (PYY3–36-NPY) axis, satiety, and weight loss in diet-induced obesity (DIO) mice. DIO mice were fed standard lab chow diets or varied doses of b-glucan for 6 weeks. Energy intake, satiety, body weight changes and peptide Y-Y3-36 (PYY3-36) were measured together with a satiety test and measurement of neuropeptide Y (NPY) mRNA expression in the hypothalamic arcuate nucleus (Arc). The average energy intake (-13%, po0.05) and body weight gain was lower with increasing b-glucan over 6 wk with acute suppression of energy intake over 4 h. …
Metabolic Parameters And Emotionality Are Little Affected In G-Protein Coupled Receptor 12 (Gpr12) Mutant Mice, Elisabeth Frank, Yizhen Wu, Naomi Piyaratna, William James Body, P Snikeris, Timothy South, Anna-Karin Gerdin, Mikael Bjursell, Mohammad Bohlooly-Y, Leonard H. Storlien, Xu-Feng Huang
Metabolic Parameters And Emotionality Are Little Affected In G-Protein Coupled Receptor 12 (Gpr12) Mutant Mice, Elisabeth Frank, Yizhen Wu, Naomi Piyaratna, William James Body, P Snikeris, Timothy South, Anna-Karin Gerdin, Mikael Bjursell, Mohammad Bohlooly-Y, Leonard H. Storlien, Xu-Feng Huang
Xu-Feng Huang
Background: G-protein coupled receptors (GPR) bear the potential to serve as yet unidentified drug targets for psychiatric and metabolic disorders. GPR12 is of major interest given its putative role in metabolic function and its unique brain distribution, which suggests a role in emotionality and affect. We tested Gpr12 deficient mice in a series of metabolic and behavioural tests and subjected them to a well-established high-fat diet feeding protocol. Methodology/Principal Findings: Comparing the mutant mice with wild type littermates, no significant differences were seen in body weight, fatness or weight gain induced by a high-fat diet. The Gpr12 mutant mice displayed …