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University of the Pacific Theses and Dissertations

Theses/Dissertations

Anti-infective agents

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A Study Of Antimicrobial Use In A Community Hospital : The Influence Of Corrective Interventions, John Greg Pech Jan 1983

A Study Of Antimicrobial Use In A Community Hospital : The Influence Of Corrective Interventions, John Greg Pech

University of the Pacific Theses and Dissertations

tudies in teaching and non-teaching hospitals have shown that one- quarter to one-third of all patients receive an antimicrobial (AMC) drug during their hospital stay." 1-30 Many of these patients (ranging from 30 to 60%), particularly those on the surgical services, have no definite evidence of infection.

Inquiry regarding the use of AMC drugs can be traced back more than two decades. In 1961, the Commission on Professional and Hospital Activities in its Professional Activity Study (CPHA-PAS) surveyed 24 hospitals." They found that approximately 27% of all patients were given an AMC drug; however, it was estimated by PAS that …


A Retrospective Evaluation On The Use Of Cephalosporins In Open-Heart Surgery, Elizabeth M. Lithco Jan 1979

A Retrospective Evaluation On The Use Of Cephalosporins In Open-Heart Surgery, Elizabeth M. Lithco

University of the Pacific Theses and Dissertations

On December 7, 1972, a hearing was held in Washington, D.C. on the use and abuse of antimicrobials. Senator Gaylor Nelson of the Sub-committee on the Monopoly of the Select Committee on Small Business stated, "Antibiotics are among the most frequently prescribed drugs in this country exceeded only by the psychoactive drugs." Dr. Charles C. Edwards, former Commissioner of the Food and Drug Administration, recognized that a problem existed and recommended the establishment of a National Task Force on the clinical use of antimicrobials (Kunin, et al., 1973).

The following examples of illustrate problems the medical profession faces with antimicrobials. …