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Full-Text Articles in Medicine and Health Sciences
Investigating Bzip Recognition Of Dna Sequences Through A Knob-Socket Perspective, Aaron Tran
Investigating Bzip Recognition Of Dna Sequences Through A Knob-Socket Perspective, Aaron Tran
University of the Pacific Theses and Dissertations
To investigate whether higher order packing interactions confer protein-DNA specificity, a modified Knob-Socket (KS) model was used to analyze the interface of bZIP-DNA crystal structures. The KS analysis identified a nine-residue quadripartite recognition core consisting of four contiguous KS pockets P1, P2, N3, and N4 that each pack one of the four DNA half-site bases in the target sequence. Only one base per base pair packs, and these interactions are split across the DNA strands: the first two positive strand positions 1p and 2p pack into P1 and P2 while the last two negative strand positions 3n and 4n pack …
Targeting Ribonucleotide Reductase For Breast Cancer Treatment, Nahid Sultana
Targeting Ribonucleotide Reductase For Breast Cancer Treatment, Nahid Sultana
University of the Pacific Theses and Dissertations
Breast cancer is the second most common type of cancer in the world. Hormone receptor (HR) positive breast cancer (BC) is a prevalent disease accounting for approximately 2 million new cases globally. Almost 70-80% of breast cancer patients are women with a positive score for the estrogen receptor (ER). Triple-negative breast cancer (TNBC) which have a negative score for estrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor receptor type 2 (HER2) is considered an aggressive histological breast cancer subtype with limited treatment options.Frequently, doxorubicin (DOXO)-based chemotherapy is utilized in this patient population due to the lack of …
Evaluation Of Human Stem Cell-Derived Neurons In 2d And 3d Cultures For Neurodevelopmental Studies, Epilepsy Disease Modeling And Drug Discovery, Hamed Salmanzadeh-Dozdabi
Evaluation Of Human Stem Cell-Derived Neurons In 2d And 3d Cultures For Neurodevelopmental Studies, Epilepsy Disease Modeling And Drug Discovery, Hamed Salmanzadeh-Dozdabi
University of the Pacific Theses and Dissertations
Human stem cells have revolutionized the study of early neural development, offering a powerful tool to investigate the complex processes involved in the formation of the nervous system. In this study, the human pluripotent stem cell line, TERA2.cl.SP12, was utilized to derive neuroglial cells and to determine their differentiation and functional maturation up to one year in culture; this model was then investigated as a new tool for the study of neurodevelopmental toxicity, for seizure modeling and as a screening method for the investigation of new anticonvulsants. Immunocytochemistry experiments determined that non-differentiated cells expressed the stem cell marker Oct-3/4 and, …
Exercise Behavior And Recreational Sports Participation Predicts Academic Success In University Students, Natalie Matian
Exercise Behavior And Recreational Sports Participation Predicts Academic Success In University Students, Natalie Matian
University of the Pacific Theses and Dissertations
Most universities offer fitness and recreational opportunities. Few prospective studies have measured the effect of those services on academic outcomes. The purpose of this study is to evaluate the effect of exercise behavior and recreational sport participation on student success. We tracked 1,507 students at a private D1 university for 4 years. Upon completion of the 2017-2018 academic year, we exported a registry of every undergraduate student who accessed the university fitness center. We documented how often students swiped into the recreation facility and participated in group exercise classes, personal training sessions, and rock tower usage; these served as independent …
Fall Risk Among Older Adults: Major Risk Factors, Primary Assessment Tools, And The Influence Of Medications, Marie Roseann Jensen
Fall Risk Among Older Adults: Major Risk Factors, Primary Assessment Tools, And The Influence Of Medications, Marie Roseann Jensen
University of the Pacific Theses and Dissertations
Fall risk among older adult is a worldwide public health problem. As the older adult population is continuing to increase, addressing this issue is critical. Several fall risk assessment tools have been designed to help predict various risk factors. Among these assessment tools is the Hendrich II Fall Risk Model (HIIFRM). This tool uses evidence-based risk factors including mental status, sex, functional status, and whether the patient is taking antileptics and/or benzodiazepines. The purpose of this paper is to validate the HFRM, explore additional variables that increase the likelihood of falling including both past falls and the number of prescription …
Role Of Cysteine Redox State In Altering The Epithelial-Mesenchymal Transition In Lung Cancer, Md Anisur Rahman
Role Of Cysteine Redox State In Altering The Epithelial-Mesenchymal Transition In Lung Cancer, Md Anisur Rahman
University of the Pacific Theses and Dissertations
Epithelial-mesenchymal transition is a process by which cancer cells increase their capability for metastasis. EMT involves conversion of epithelial cells into a mesenchymal phenotype which makes cancer cells more invasive and motile. Lung cancer has the highest mortality rate among different types of cancers globally. Lung cancer exists in various types, the most prevalent of which is non-small cell lung cancer (NSCLC). Several factors, including oxidative stress, can induce EMT in cancer cells. However, the mechanism of how reactive oxygen species (ROS)-induced changes in cysteine redox state affect EMT remains elusive. Our studies aim to understand this mechanism by inducing …
The Discovery And Characterization Of Novel Potent 5-Substituted 3, 3’, 4’, 7-Tetramethoxyflavonoid Dna Triplex Specific Binding Ligands, Vanessa Marie Rangel
The Discovery And Characterization Of Novel Potent 5-Substituted 3, 3’, 4’, 7-Tetramethoxyflavonoid Dna Triplex Specific Binding Ligands, Vanessa Marie Rangel
University of the Pacific Theses and Dissertations
Chemotherapy works by killing fast dividing cells. Unfortunately, these drugs are not specific to cancer tissue and can damage normal cells. Chemotherapy is like taking poison and hoping it kills the cancer cells before it kills you. As an alternative, many researchers have investigated the use of antigene therapy to selectively target cancer causing genes to avoid off target effects. Although promising, the theory is limited by the stability of the triplex structure. Here, we report the discovery of potent triplex binding ligands derived from the natural product quercetin. Chemical derivatives of 5-substituted 3, 3’, 4’, 7-tetramethoxyquercetin derivatives were characterized …