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Full-Text Articles in Medicine and Health Sciences
Measuring The Effects Of Ctrp3 And Metformin On H4iie Hepatocyte Metabolism Using Seahorse Extracellular Flux Analyzer, Forrest J. Longway
Measuring The Effects Of Ctrp3 And Metformin On H4iie Hepatocyte Metabolism Using Seahorse Extracellular Flux Analyzer, Forrest J. Longway
Undergraduate Honors Theses
Non-alcoholic fatty liver disease (NAFLD) results from an unequal uptake/storage and export/oxidation of lipids within the liver and is often a secondary disease to type II diabetes (22). NAFLD causes this imbalance of lipids by altering glucose and lipid metabolism, which corresponds to a decrease in mitochondrial function leading to failure of the liver. One established treatment for type II diabetes and NAFLD is the drug metformin, which has similar properties to the newly discovered CTRP 3 protein which is part of a group of bioactive molecules secreted by adipose tissue, collectively termed adipokines (2-4). Both have similar effects on …