Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 3 of 3
Full-Text Articles in Medicine and Health Sciences
Investigation Of The Lipid Peroxidation, Antioxidant Substances, Antioxidant Vitamins And Some Hematologic-Biochemical Parameter Levels In Gentamycine Induced Nephrotoxicosis In Dogs, Ali̇ Erteki̇n, Mehmet Karaca, Hasan Altan Akkan, Mustafa Cemek, Nesli̇han Ormanci
Investigation Of The Lipid Peroxidation, Antioxidant Substances, Antioxidant Vitamins And Some Hematologic-Biochemical Parameter Levels In Gentamycine Induced Nephrotoxicosis In Dogs, Ali̇ Erteki̇n, Mehmet Karaca, Hasan Altan Akkan, Mustafa Cemek, Nesli̇han Ormanci
Turkish Journal of Veterinary & Animal Sciences
In our study, malondialdehyde, antioxidant vitamins, antioxidant substances and some hematologic-biochemical parameter levels in nephrotoxicosis were investigated. Six dogs were used in the study. Blood samples taken before the experiment were used as the control. Blood samples were taken on days 2, 5, 7 and 10 during the experiment. During analysis, we found that the statistical changes were not significant in the retinol and Vitamin C levels of the experiment group when compared to those of the control group. \beta-carotene (P < 0.05) and Vitamin E (P < 0.001) levels were significantly decreased. Increases in the levels of malondialdehyde, seruloplasmin and urine \gamma-glutamyl transferase (GGT) enzyme were P < 0.001, while decreases in the amounts of glutathione were P < 0.001. We also found that changes in erythrocyte and hemotocrit levels were not significant. On the other hand, increases in the levels of leucocyte (P < 0.01), creatinin and blood urea nitrogen (BUN) P < 0.001 were significant. In conclusion, oxidative damage can occur in cells in nephrotoxicosis, the use of antioxidants could be of benefit during treatment with chemotherapeutics.
Lipid Peroxidation, Antioxidant Enzymes And Levels Of Nitric Oxide In Sheep Infected With Fasciola Hepatica, Fulya Benzer, Sema Temi̇zer Ozan
Lipid Peroxidation, Antioxidant Enzymes And Levels Of Nitric Oxide In Sheep Infected With Fasciola Hepatica, Fulya Benzer, Sema Temi̇zer Ozan
Turkish Journal of Veterinary & Animal Sciences
In this study, the levels of malondialdehyde and activities of catalase and glutathione peroxidase, two antioxidant enzymes, and the levels of nitric oxide in sheep infected with Fasciola hepatica were measured. The level of malondialdehyde in plasma and tissue was measured according to the Yagi and Ohkawa methods, respectively. The activities of catalase and glutathione peroxidase were measured according to the methods of Aebi and Beutler, respectively. The level of nitric oxide was determined by the method of Griess. There were no statistically significant differences in the level of plasma malondialdehyde, activities of erythrocytes catalase and glutathione peroxidase and levels …
Liver Antioxidant Systems And Lipid Peroxidation In Sea Bass (Dicentrarchus Labrax)Adapted To Fresh Water, Aysel Şahan, Ergül Belge Kurutaş, Suat Di̇kel
Liver Antioxidant Systems And Lipid Peroxidation In Sea Bass (Dicentrarchus Labrax)Adapted To Fresh Water, Aysel Şahan, Ergül Belge Kurutaş, Suat Di̇kel
Turkish Journal of Veterinary & Animal Sciences
Changes in the antioxidant systems of the liver tissues of sea bass (Dicentrarchus labrax) adapted to low salinity levels (0 ) were investigated. Malondialdehyde levels, as a specific indicator of oxidant stress, were determined. The results indicated highly significant differences among the test and control groups (P < 0.05). Some histopathological destruction, liver weight and hepatosomatic index values were determined at high levels and, moreover, superoxide dismutase, glutathione peroxidase (GPX), glucose-6phosphate-dehydrogenase and malondialdehyde activities increased, while reducted glutathione levels decreased in comparison with the control group. An increase in the malondialdehyde level was determined to be an indicator of lipid peroxidation.