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Turkish Journal of Medical Sciences

Alzheimer disease

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Full-Text Articles in Medicine and Health Sciences

Evaluation Of Brain Perfusion In Alzheimer Disease With Perfusion Computed Tomography And Comparison To Elderly Patient Without Dementia, Tüli̇n Yildirim, Başak Karakurum Göksel, Şenay Demi̇r, Nai̇me Tokmak, Meli̇ha Tan Jan 2016

Evaluation Of Brain Perfusion In Alzheimer Disease With Perfusion Computed Tomography And Comparison To Elderly Patient Without Dementia, Tüli̇n Yildirim, Başak Karakurum Göksel, Şenay Demi̇r, Nai̇me Tokmak, Meli̇ha Tan

Turkish Journal of Medical Sciences

Background/aim: The aim of this study was to evaluate perfusion computed tomography (PCT) findings in patients with Alzheimer disease and to compare them with those of patients without dementia. Materials and methods: PCT was performed in 35 patients: 20 with Alzheimer disease (mean age, 69.7 ± 5.5 years) and 15 control subjects (mean age, 67.5 ± 3.5 years). Control subjects were elderly individuals with no cognitive problems who were admitted with headaches. All PCT examinations were performed on a 4-slice CT unit. The PCT analysis software program was used to calculate regional cerebral blood flow (rCBF), regional cerebral blood volume …


Role Of Autophagy In The Pathogenesis Of Alzheimer Disease, Muhammet Cemal Kizilarslanoğlu, Zekeri̇ya Ülger Jan 2015

Role Of Autophagy In The Pathogenesis Of Alzheimer Disease, Muhammet Cemal Kizilarslanoğlu, Zekeri̇ya Ülger

Turkish Journal of Medical Sciences

Alzheimer disease (AD) is the most common progressive neurodegenerative disorder causing increased morbidity and mortality. It is characterized by accumulation of amyloid-β in neurons. As there is no known definitive treatment of this disorder, studies trying to determine its exact pathogenetic pathways and target therapies for these specific pathways are being rapidly conducted. Autophagy is one of the areas of interest in studies on the pathogenesis of AD. It is a process of self-digestion that is thought to be a response to stressors and allows cells to adapt to environmental changes. There is accumulating evidence showing an association between autophagy …


Alzheimer Disease And Anesthesia, Gözde İnan, Zerri̇n Özköse Şatirlar Jan 2015

Alzheimer Disease And Anesthesia, Gözde İnan, Zerri̇n Özköse Şatirlar

Turkish Journal of Medical Sciences

Alzheimer disease (AD) is one of the most common neurodegenerative diseases and the most prevalent form of dementia. Some factors in the development of AD, age being the best-known one, have been suggested; however, no causes have been found yet. The pathophysiology of the disease is highly complex, current therapies are palliative, and a cure is still lacking. Adverse effects of anesthetics in the elderly have been reported since the 1950s; however, awareness of this old problem has recently gained importance again. Whether exposure to surgery and general anesthesia (GA) is associated with the development of AD has been questioned. …


Vitamin D Status And Its Association With Gradual Decline In Cognitive Function, Yusuf Yeşi̇l, Mehmet Emi̇n Kuyumcu, Özgür Kara, Burçi̇n Halaçli, Sezgi̇n Etgül, Muhammet Cemal Kizilarslanoğlu, Burcu Balam Yavuz, Münevver Özcan, Meltem Gülhan Hali̇l, Eylem Şahi̇n Cankurtaran, Mustafa Cankurtaran, Servet Arioğul Jan 2015

Vitamin D Status And Its Association With Gradual Decline In Cognitive Function, Yusuf Yeşi̇l, Mehmet Emi̇n Kuyumcu, Özgür Kara, Burçi̇n Halaçli, Sezgi̇n Etgül, Muhammet Cemal Kizilarslanoğlu, Burcu Balam Yavuz, Münevver Özcan, Meltem Gülhan Hali̇l, Eylem Şahi̇n Cankurtaran, Mustafa Cankurtaran, Servet Arioğul

Turkish Journal of Medical Sciences

Background/aim: To compare plasma vitamin D concentrations among patients with normal cognitive function (control group), mild cognitive impairment (MCI), and Alzheimer disease (AD). Materials and methods: In total, 158 patients with AD, 228 patients with MCI, and 603 control subjects were included. Plasma levels of 25-hydroxyvitamin D were measured after comprehensive geriatric assessment and compared among groups. SPSS 15.0 was used for statistical analysis. Results: Mean levels of 25-hydroxyvitamin D were significantly different among the 3 groups of AD patients, MCI patients, and controls (P < 0.001). Post hoc analysis revealed that the levels were significantly lower in the MCI group than the control group (P = 0.002) and significantly lower in the AD group than the control group (P = 0.003). Multivariate analysis showed that age (OR: 1.070, 95% CI: 1.025-1.116, P = 0.002), instrumental activities of daily living score (OR: 0.920, 95% CI: 0.850-0.995, P = 0.037), 25-hydroxyvitamin D level (OR: 0.959, 95% CI: 0.932-0.987, P = 0.004), and diabetes mellitus (OR: 2.476, 95% CI: 1.153-5.319, P = 0.020) were factors independently associated with AD. Conclusion: This study demonstrated that there is a correlation between plasma 25-hydroxyvitamin D levels and cognitive functions.


Potential Genetic Biomarkers In The Early Diagnosisof Alzheimer Disease: Apoe And Bin1, Gülhan Kaya, Esra Gündüz, Muradi̇ye Acar, Ömer Faruk Hati̇poğlu, Burcu Acar, Ati̇lla İlhan, Mehmet Gündüz Jan 2015

Potential Genetic Biomarkers In The Early Diagnosisof Alzheimer Disease: Apoe And Bin1, Gülhan Kaya, Esra Gündüz, Muradi̇ye Acar, Ömer Faruk Hati̇poğlu, Burcu Acar, Ati̇lla İlhan, Mehmet Gündüz

Turkish Journal of Medical Sciences

Background/aim: Alzheimer disease (AD) is triggered by interactions of multiple genetic and environmental factors. The APOE gene E4 allele is the best-known risk factor for AD, yet it represents a small ratio of genetic factors. According to genome-wide association studies, the BIN1 gene is the second important risk factor for AD, following the APOE gene. We aimed to identify a novel biomarker indicating susceptibility to AD by investigating APOE alleles and BIN1 gene polymorphisms in a Turkish population. Materials and methods: Fifty-three AD patients and 56 controls were included to examine polymorphism and allele frequency of the APOE and BIN1 …


Is Alzheimer Disease Related To Age-Related Macular Degeneration?, Seden Demi̇rci̇, Ali̇me Güneş, Kadi̇r Demi̇rci̇, Serpi̇l Demi̇rci̇, Levent Tök, Özlem Tök Jan 2015

Is Alzheimer Disease Related To Age-Related Macular Degeneration?, Seden Demi̇rci̇, Ali̇me Güneş, Kadi̇r Demi̇rci̇, Serpi̇l Demi̇rci̇, Levent Tök, Özlem Tök

Turkish Journal of Medical Sciences

Background/aim: To compare the cognitive functions and define the frequency of Alzheimer disease (AD) between participants with and without age-related macular degeneration (AMD). Materials and methods: Fifty-nine patients with late-stage AMD (74.3 ± 7.3 years) and 49 age-, sex-, and education-matched control subjects were compared for the presence of AD according to the guidelines of the National Institute of Neurological and Communicative Disorders and Stroke and the Alzheimer's Disease and Related Disorders Association (NINCDS-ADRDA). Detailed neuropsychological tests were performed for all subjects. Results: Neuropsychiatric tests scores were lower in the AMD group than the control group. The frequency of AD …


Evaluation Of Retinal Nerve Fiber Layer Thickness In Alzheimer Disease Usingspectral-Domain Optical Coherence Tomography, Ali̇me Güneş, Seden Demi̇rci̇, Levent Tök, Özlem Tök, Serpi̇l Demi̇rci̇ Jan 2015

Evaluation Of Retinal Nerve Fiber Layer Thickness In Alzheimer Disease Usingspectral-Domain Optical Coherence Tomography, Ali̇me Güneş, Seden Demi̇rci̇, Levent Tök, Özlem Tök, Serpi̇l Demi̇rci̇

Turkish Journal of Medical Sciences

Background/aim: To evaluate the retinal nerve fiber layer (RNFL) thickness in patients with Alzheimer disease (AD) and to compare the results with those of healthy controls. Materials and methods: Forty patients (mean age: 75.02 ± 6.34 years; 23 women) with untreated AD and 40 age-, sex-, and education-matched healthy patients were examined in this case-control prospective study. All patients underwent detailed ophthalmic and neurological examination. The Mini Mental State Examination (MMSE) was performed and RNFL thickness was measured using spectral-domain optical coherence tomography. The association between RNFL and MMSE score was also assessed. Results: The average RNFL thickness was 84 …


A Comparison Of Hair And Serum Trace Elements In Patients With Alzheimer Disease And Healthy Participants, Emi̇ne Rabi̇a Koç, Ati̇lla İlhan, Zübeyde Aytürk, Burcu Acar, Mukaddes Gürler, Aynur Altuntaş, Mustafa Karapi̇rli̇, Abdurrahman Sai̇d Bodur Jan 2015

A Comparison Of Hair And Serum Trace Elements In Patients With Alzheimer Disease And Healthy Participants, Emi̇ne Rabi̇a Koç, Ati̇lla İlhan, Zübeyde Aytürk, Burcu Acar, Mukaddes Gürler, Aynur Altuntaş, Mustafa Karapi̇rli̇, Abdurrahman Sai̇d Bodur

Turkish Journal of Medical Sciences

Background/aim: To determine whether there was a difference between serum and hair trace elements' concentrations in patients with Alzheimer disease (AD) and healthy participants. Materials and methods: Hair and serum copper, selenium, zinc, magnesium, manganese, and iron levels were measured by inductively coupled plasma-mass spectrometry in patients with AD and healthy participants, and the obtained results were statistically compared. Results: The mean hair selenium and zinc levels of patients with AD were significantly lower than the levels found for control participants (P < 0.05). Patients with AD had significantly higher mean hair copper and manganese levels than the controls. There were no significant differences between AD patients and controls with respect to the hair iron and magnesium levels (P > 0.05). Hair and serum trace element (copper, selenium, zinc, magnesium, manganese, and iron) levels in patients with AD …


Association Of Clu And Tlr2 Gene Polymorphisms With Late-Onsetalzheimer Disease In A Northwestern Iranian Population, Nasim Sohrabifar, Jalal Gharesouran, Mahnaz Talebi, Morteza Ghojazadeh, Seiied Mojtaba Mohaddes Ardebili Jan 2015

Association Of Clu And Tlr2 Gene Polymorphisms With Late-Onsetalzheimer Disease In A Northwestern Iranian Population, Nasim Sohrabifar, Jalal Gharesouran, Mahnaz Talebi, Morteza Ghojazadeh, Seiied Mojtaba Mohaddes Ardebili

Turkish Journal of Medical Sciences

Background/aim: A number of genetic variants from different genes have been reported to be related to late-onset Alzheimer disease (LOAD) susceptibility. From these genes, polymorphisms in CLU and TLR2 have been replicated in several studies. In this study we examined the association of rs11136000 in CLU and the TLR2 -196 to -174 del polymorphism with the risk of LOAD in a northwestern Iranian population. Materials and methods: We conducted a case-control study with a dataset of 160 LOAD patients and 163 healthy controls. To examine polymorphisms of CLU and TLR2 in LOAD we used the PCR/RFLP method and genotype frequencies …


Nerve Growth Factor Receptors In Dementia, Manoochehr Messripour, Abolfazl Nazarian, Azadeh Mesripour, Iman Mohammadi Jan 2015

Nerve Growth Factor Receptors In Dementia, Manoochehr Messripour, Abolfazl Nazarian, Azadeh Mesripour, Iman Mohammadi

Turkish Journal of Medical Sciences

Background/aim: Nerve growth factor (NGF) promotes the survival and differentiation of sensory and sympathetic neurons. Several studies have found that certain neuropathological factors stimulate NGF receptor expression and release the truncated nerve growth factor receptor (TNGFR) to biological fluids. The aim of this pilot study was to determine urine TNGFR levels in patients with dementia and to verify whether TNGFR can be used as a biomarker of dementia. Materials and methods: Twelve patients with dementia and 12 healthy individuals were asked to voluntarily participate in this study. Ages, sexes, and weights were matched. The first morning urine samples were collected …


The Value Of Fdg-Pet/Ct By Using 3-Dimensional Stereotactic Surface Projection Software Analysis In The Differential Diagnosis Of Dementia, Esra Arslan, Özgül Ekmekçi̇oğlu, Fatma Arzu Görtan, Zeynep Funda Engi̇n Akcan, Meli̇h Engi̇n Erkan, Haci Murat Emül, Meti̇n Halaç, Tevfi̇k Fi̇kret Çermi̇k, Keri̇m Sönmezoğlu Jan 2015

The Value Of Fdg-Pet/Ct By Using 3-Dimensional Stereotactic Surface Projection Software Analysis In The Differential Diagnosis Of Dementia, Esra Arslan, Özgül Ekmekçi̇oğlu, Fatma Arzu Görtan, Zeynep Funda Engi̇n Akcan, Meli̇h Engi̇n Erkan, Haci Murat Emül, Meti̇n Halaç, Tevfi̇k Fi̇kret Çermi̇k, Keri̇m Sönmezoğlu

Turkish Journal of Medical Sciences

Background/aim: To retrospectively reevaluate brain fluor-18-fluorodeoxyglucose positron emission tomography (FDG-PET) imaging studies with 3-dimensional stereotactic surface projection (NEUROSTAT) software in order to detect changes in regional brain metabolism and to find out its contribution to the final diagnosis. Materials and methods: A total of 48 cases were included in this study. According to clinical evaluation and neuropsychometric test results, there were 17 (35%) patients with probable Alzheimer disease (AD), 17 (35%) patients with probable frontotemporal dementia (FTD), and 14 (30%) patients with undefined advanced dementia. Brain FDG-PET imaging studies were interpreted visually and also using 3-dimensional stereotactic surface projection. Results: …


Postoperative Cognitive Dysfunction And Alzheimer Disease, Berri̇n Işik Jan 2015

Postoperative Cognitive Dysfunction And Alzheimer Disease, Berri̇n Işik

Turkish Journal of Medical Sciences

Alzheimer disease (AD) is the most prevalent neurodegenerative disorder in elderly people. Patients with AD appear to be particularly at risk for cognitive deterioration following anesthesia. Some in vitro studies suggest that exposure to general anesthesia (GA) promotes the AD process. On the other hand, there are no clinical studies that clearly demonstrate that GA is a cause of cognitive dysfunction in patients with probable AD. The aim of this research was to discuss the relation between postoperative cognitive dysfunction (POCD) and AD according to the literature. In vivo studies examining AD biomarkers postoperatively and in vitro studies exploring amyloid-β …


Nutritional Issues In Dementia Patients, Mustafa Kemal Kiliç, Fati̇h Sümer, Zekeri̇ya Ülger Jan 2015

Nutritional Issues In Dementia Patients, Mustafa Kemal Kiliç, Fati̇h Sümer, Zekeri̇ya Ülger

Turkish Journal of Medical Sciences

Dementia is an inevitable disease of aging, leading not only to diminished cognitive ability but also behavioral changes, malnutrition, pressure sores, and infections. Acknowledging common problems and their solutions is essential for any health service worker who deals with demented geriatric patients.


Alzheimer Disease, Inflammation, And Novel Inflammatory Marker: Resistin, Muhammet Cemal Kizilarslanoğlu, Özgür Kara, Yusuf Yeşi̇l, Mehmet Emi̇n Kuyumcu, Zeynel Abi̇di̇n Öztürk, Mustafa Cankurtaran, Samed Rahatli, Nagehan Pakaşti̇çali, Esat Çinar, Meltem Gülhan Hali̇l, Burçi̇n Şener, Eylem Şahi̇n Cankurtaran, Servet Arioğul Jan 2015

Alzheimer Disease, Inflammation, And Novel Inflammatory Marker: Resistin, Muhammet Cemal Kizilarslanoğlu, Özgür Kara, Yusuf Yeşi̇l, Mehmet Emi̇n Kuyumcu, Zeynel Abi̇di̇n Öztürk, Mustafa Cankurtaran, Samed Rahatli, Nagehan Pakaşti̇çali, Esat Çinar, Meltem Gülhan Hali̇l, Burçi̇n Şener, Eylem Şahi̇n Cankurtaran, Servet Arioğul

Turkish Journal of Medical Sciences

Background/aim: Inflammation may play an important role in Alzheimer disease (AD) pathogenesis. A growing amount of evidence indicates that resistin has hallmark regulatory functions such as inflammatory states. The aim of this study was to determine whether plasma resistin levels would be useful in the diagnosis of patients with AD and to investigate the relationships between resistin and other inflammatory markers such as hs-CRP and TNF-α. Materials and methods: In this cross-sectional study, 38 AD patients and 32 control subjects with normal cognitive function aged 65 years and over were included. The diagnosis of AD was made according to DSM-IV …


Forensic Medicine Evaluation Of Alzheimer Patients: A Series From Ankara, Turkey, Mehmet Cavlak, Ramazan Akçan, Ali̇ Riza Tümer, Aysun Balseven Odabaşi, Aykut Lale, Mahmut Şeri̇f Yildirim, Eyup Ruşen Heybet Jan 2015

Forensic Medicine Evaluation Of Alzheimer Patients: A Series From Ankara, Turkey, Mehmet Cavlak, Ramazan Akçan, Ali̇ Riza Tümer, Aysun Balseven Odabaşi, Aykut Lale, Mahmut Şeri̇f Yildirim, Eyup Ruşen Heybet

Turkish Journal of Medical Sciences

Background/aim: Pathophysiological changes due to Alzheimer disease and increasing age might result in situations requiring forensic evaluation in the elderly. Judicial bodies might need forensic evaluation of trauma and the decision-making capacity of Alzheimer patients. This study aimed to determine the demographic and clinical characteristics of Alzheimer patients seen for forensic evaluation. Materials and methods: Forensic records issued by the Department of Forensic Medicine of Hacettepe University in 2012 and 2013 were investigated. Patients with Alzheimer disease were included in the study and were analyzed in terms of age, sex, reason for application, comorbid medical conditions, occupation, and place and …


Plasma 8-Isopgf2? And Serum Melatonin Levels In Patients With Minimal Cognitive Impairment And Alzheimer Disease, Fevzi̇ye Burcu Şi̇ri̇n, Duygu Kumbul Doğuç, Hüseyi̇n Vural, İbrahi̇m Eren, İkbal İnanli, Recep Sütcü, Namik Deli̇baş Jan 2015

Plasma 8-Isopgf2? And Serum Melatonin Levels In Patients With Minimal Cognitive Impairment And Alzheimer Disease, Fevzi̇ye Burcu Şi̇ri̇n, Duygu Kumbul Doğuç, Hüseyi̇n Vural, İbrahi̇m Eren, İkbal İnanli, Recep Sütcü, Namik Deli̇baş

Turkish Journal of Medical Sciences

Background/aim: F2α-isoprostane is accepted as an oxidative stress indicator and melatonin shows neuroprotective effects by antioxidative and antiamyloidogenic influences. By measuring these in patients diagnosed with minimal cognitive impairment (MCI) and Alzheimer-type dementia, we intended to demonstrate whether the measurement of these markers contributes to early diagnosis of Alzheimer disease (AD) in the MCI stage or not. Materials and methods: Three groups (n = 63) were created: the AD group, MCI group, and control group. Serum melatonin levels were measured by radioimmunoassay method, and plasma total 8-isoPGF2α levels were measured by enzyme immunoassay method. Results: Significant differences were observed in …


Malnutrition Is Associated With Dementia Severity And Geriatricsyndromes In Patients With Alzheimer Disease, Demet Yildiz, Ni̇lüfer Büyükkoyuncu Pekel, Ahmet Kasim Kiliç, Eli̇f Nalan Tolgay, Fati̇h Tufan Jan 2015

Malnutrition Is Associated With Dementia Severity And Geriatricsyndromes In Patients With Alzheimer Disease, Demet Yildiz, Ni̇lüfer Büyükkoyuncu Pekel, Ahmet Kasim Kiliç, Eli̇f Nalan Tolgay, Fati̇h Tufan

Turkish Journal of Medical Sciences

Background/aim: Malnutrition is associated with increased morbidity and mortality in patients with Alzheimer disease (AD). In this study, we aimed to screen for malnutrition and geriatric syndromes and seek their associations in patients with AD. Materials and methods: The Mini Mental State Examination (MMSE), Mini Nutritional Assessment (MNA), Katz Activities of Daily Living (ADL), and Lawton Instrumental Activities of Daily Living (IADL) tests were applied. Mean daily oral fluid intake was assessed according to patients' and relatives' declarations. Results: Seventy-six patients with a mean age of 79 ± 7.4 years were included. Most of the patients had mild or moderate …


The Reliability And Validity Of The Turkish Version Of Theneuropsychiatric Inventory-Clinician, Eylem Şahi̇n Cankurtaran, Mustafa Danişman, Hasan Tutar, Semra Ulusoy Kaymak Jan 2015

The Reliability And Validity Of The Turkish Version Of Theneuropsychiatric Inventory-Clinician, Eylem Şahi̇n Cankurtaran, Mustafa Danişman, Hasan Tutar, Semra Ulusoy Kaymak

Turkish Journal of Medical Sciences

Background/aim: The Neuropsychiatric Inventory-Clinician (NPI-C) scale is one of the best-known scales for evaluating the behavioral and psychological symptoms of dementia. This study aimed to assess the reliability and validity of the Turkish version of the NPI-C scale in patients with Alzheimer disease (AD). Materials and methods: The NPI-C scale was administered to 125 patients with AD. For reliability, both Cronbach's α and interrater reliability were analyzed. The Behavioral Pathology in Alzheimer's Disease (BEHAVE-AD) scale was applied for validity and, in addition, the Mini Mental State Examination (MMSE), Instrumental Activities of Daily Living (IADL) scale, and Disability Assessment of Dementia …


Neurodegeneration In Ocular And Central Nervous Systems: Optical Coherence Tomography Study In Normal-Tension Glaucoma And Alzheimer Disease*, Muhsi̇n Eraslan, Eren Çerman, Osman Çeki̇ç, Sevcan Balci, Volkan Deri̇ci̇oğlu, Özlem Şahi̇n, Devran Süer, Biman Chabou, Emi̇ne Neşe Tuncer Elmaci Jan 2015

Neurodegeneration In Ocular And Central Nervous Systems: Optical Coherence Tomography Study In Normal-Tension Glaucoma And Alzheimer Disease*, Muhsi̇n Eraslan, Eren Çerman, Osman Çeki̇ç, Sevcan Balci, Volkan Deri̇ci̇oğlu, Özlem Şahi̇n, Devran Süer, Biman Chabou, Emi̇ne Neşe Tuncer Elmaci

Turkish Journal of Medical Sciences

Background/aim: To evaluate, in vivo, the optical coherence tomography (OCT) of the retinal nerve fiber layer (RNFL) and ganglion cell complex (GCC) in patients with normal-tension glaucoma (NTG) and those with Alzheimer disease (AD) in comparison with healthy subjects. Materials and methods: This cross-sectional study included 18 patients with NTG, 20 with AD, and 20 control subjects. An ophthalmologic examination and OCT scans of both eyes were performed in all patients. Results: There was a significant reduction in peripapillary RNFL thickness and macular GCC thickness and a significant increase in the global loss volume (GLV) rate in both the NTG …


Effect Of Capparis Spinosa L. On Cognitive Impairment Induced By D-Galactosein Mice Via Inhibition Of Oxidative Stress, Nergi̇z Hacer Turgut, Haki̇ Kara, Emre Arslanbaş, Derya Güli̇z Mert, Bektaş Tepe, Hüseyi̇n Güngör Jan 2015

Effect Of Capparis Spinosa L. On Cognitive Impairment Induced By D-Galactosein Mice Via Inhibition Of Oxidative Stress, Nergi̇z Hacer Turgut, Haki̇ Kara, Emre Arslanbaş, Derya Güli̇z Mert, Bektaş Tepe, Hüseyi̇n Güngör

Turkish Journal of Medical Sciences

Background/aim: To determine the phenolic acid levels and DNA damage protection potential of Capparis spinosa L. seed extract and to investigate the effect of the extract on cognitive impairment and oxidative stress in an Alzheimer disease mice model. Materials and methods: Thirty BALB/c mice divided into 5 groups (control??, D-galactose, D-galactose + C. spinosa 50, D-galactose + C. spinosa 100, D-galactose + C. spinosa 200) were used. Mice were administered an injection of D-galactose (100 mg/kg, subcutaneous) and orally administered C. spinosa (50, 100, or 200 mg/kg) daily for 8 weeks. Results: Syringic acid was detected and the total amount …


Why Is Alzheimer's Disease Confused With Other Dementias?, Dursun Aygün, İbrahi̇m Levent Güngör Jan 2015

Why Is Alzheimer's Disease Confused With Other Dementias?, Dursun Aygün, İbrahi̇m Levent Güngör

Turkish Journal of Medical Sciences

Alzheimer disease (AD) is the most common cause of dementia. The cardinal manifestation of AD is progressive loss of memory. However, there are some nonamnestic presentations of AD, also called atypical AD. Symptoms of AD can sometimes start suddenly. In the presence of atypical symptoms or sudden onset, it may be difficult to distinguish AD from other dementias. We would like to discuss the confusing features of atypical AD that mimic other dementias. In this review, the literature associated with confusing features of AD, suggesting other dementia syndromes, is reviewed. In addition, a case of semantic dementia (SD) with the …


The Effects And Interactions Of Apoe And Aph-1a Polymorphisms In Alzheimer Disease, Burcu Acar Çi̇nleti̇, Ni̇lgül Yardimci, Zübeyde Aytürk, Ati̇lla İlhan, Gülhan Kaya, Muradi̇ye Acar, Emi̇ne Rabi̇a Koç, Esra Gündüz, Mehmet Gündüz Jan 2015

The Effects And Interactions Of Apoe And Aph-1a Polymorphisms In Alzheimer Disease, Burcu Acar Çi̇nleti̇, Ni̇lgül Yardimci, Zübeyde Aytürk, Ati̇lla İlhan, Gülhan Kaya, Muradi̇ye Acar, Emi̇ne Rabi̇a Koç, Esra Gündüz, Mehmet Gündüz

Turkish Journal of Medical Sciences

Background/aim: Alzheimer disease (AD) is characterized by the accumulation of senile plaques composed of amyloid β-peptide, which is derived from β-amyloid precursor protein through degradation by β-secretase and γ-secretase complexes. One of the major components of γ-secretase complex, anterior pharynx-defective-1 (APH-1), is responsible for the activity of the γ-secretase complex. In this study, we searched for not only the most known common genetic risk factor, APOE, but also the APH-1a gene polymorphism in AD patients in a Turkish population. Materials and methods: In this study, 49 AD patients and 45 healthy controls were included. The genetic polymorphisms and allele frequencies …


A Turkish 3-Center Study Evaluation Of Serum Folic Acid And Vitamin B12 Levels In Alzheimer Disease, Nuri̇ye Nuray Ulusu, Gökhan Yilmaz, Zübeyde Erbayraktar, Ahmet Turan Evli̇ce, Sevgi̇ Aras, Görsev Yener, Aslihan Avci Jan 2015

A Turkish 3-Center Study Evaluation Of Serum Folic Acid And Vitamin B12 Levels In Alzheimer Disease, Nuri̇ye Nuray Ulusu, Gökhan Yilmaz, Zübeyde Erbayraktar, Ahmet Turan Evli̇ce, Sevgi̇ Aras, Görsev Yener, Aslihan Avci

Turkish Journal of Medical Sciences

Background/aim: Alzheimer disease, a common proteopathy of advanced age, is characterized by cortical atrophy, neuron degeneration, neuronal loss, and accumulation of extracellular amyloid β plaques. We aimed to investigate serum vitamin B12 and folic acid levels in Alzheimer disease and other dementia patients, as a potential screening test to detect presymptomatic Alzheimer disease in Turkish patients. Materials and methods: We evaluated folic acid and vitamin B12 levels in Alzheimer disease patients as well as in other dementia and geriatric patients from Ankara, Dokuz Eylül, and Çukurova university hospitals; 290 female and male geriatric subjects were enrolled. Vitamin B12 and folic …


The Increase Of Mean Platelet Volume In Patients With Alzheimer Disease, Emi̇ne Rabi̇a Koç, Ertuğrul Uzar, Yasemi̇n Çirak, Yasemi̇n Parlak Demi̇r, Ati̇lla İlhan Jan 2014

The Increase Of Mean Platelet Volume In Patients With Alzheimer Disease, Emi̇ne Rabi̇a Koç, Ertuğrul Uzar, Yasemi̇n Çirak, Yasemi̇n Parlak Demi̇r, Ati̇lla İlhan

Turkish Journal of Medical Sciences

Vascular risk factors play an important role in the progression of Alzheimer disease (AD). Mean platelet volume (MPV) is a determinant of platelet functionality and increased MPV is associated with an increased risk of vascular inflammation. Here we aimed to examine whether MPV could be used as a marker of vascular damage in AD and to discuss the relation between MPV and other vascular risk factors. Materials and methods: A total of 109 outpatients with AD and 81 healthy controls were included in this study. Diagnosis of AD was made according to defined criteria. The Turkish version of the Mini …