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Metoclopramide Inhibits Trigeminovascular Activation:Evidence For Effective Acute Attack Treatment In Migraine, Hacer Doğanay Aydin, Doğa Vuralli, Di̇dem Tuba Akçali, Hayrunni̇sa Bolay Belen
Metoclopramide Inhibits Trigeminovascular Activation:Evidence For Effective Acute Attack Treatment In Migraine, Hacer Doğanay Aydin, Doğa Vuralli, Di̇dem Tuba Akçali, Hayrunni̇sa Bolay Belen
Turkish Journal of Medical Sciences
Background/aim: Metoclopramide is an effective and commonly used medication in acute migraine treatment but an experimental evidence base is lacking. We aimed to investigate the antimigraine effect of metoclopramide in a migraine model and whether the analgesic effect of metoclopramide was likely to be D2 receptor-mediated. Materials and methods: Cortical spreading depression (CSD) was used to model migraine in adult male Wistar rats. Five CSDs were induced by pinprick. Metoclopramide (two different doses), raclopride, or 0.9% saline were administered 30 min before CSD induction. Two hours after the experiments, brain tissues were examined for c-fos activation. Results: In metoclopramide groups …
Nitroglycerin Challenge Induces Lateralized Headache In Nasociliarynerve-Ligated Rats: Implications For Chronic Migraine, Di̇dem Tuba Akçali, Ahmet Deni̇z Belen, C.Avni̇ Babacan, Hayrunni̇sa Bolay Belen
Nitroglycerin Challenge Induces Lateralized Headache In Nasociliarynerve-Ligated Rats: Implications For Chronic Migraine, Di̇dem Tuba Akçali, Ahmet Deni̇z Belen, C.Avni̇ Babacan, Hayrunni̇sa Bolay Belen
Turkish Journal of Medical Sciences
Background/aim: Chronic migraine is a common debilitating disease with limited treatment options. We aimed to develop a novel model for chronic migraine by ligating the nasociliary nerve (NCL) and administering nitroglycerin (NTG) to exacerbate acute headache attacks. Materials and methods: Exacerbation of the headache was induced by NTG (10 mg/kg, subcutaneously) administered to male Wistar rats (n = 36) 14 days following unilateral NCL. Cutaneous and cold allodynia was tested using Von Frey (VF) filaments and acetone, respectively. Elevated plus maze (EPM) results and c-fos immunoreactivity of TNC were investigated. Results: NTG administration significantly decreased VF threshold values only in …