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Comparison Of Ischemic Preconditioning And Botulinuma Toxin Injection For The Prevention Of Ischemia-Reperfusion Injury In Musculocutaneous Flaps, Handan Derebaşinlioğlu, Anil Demi̇röz, Yağmur Aydin, Hakan Ekmekçi̇, Özlem Balci Ekmekçi̇, Övgü Aydin, Levent Cankorkmaz
Comparison Of Ischemic Preconditioning And Botulinuma Toxin Injection For The Prevention Of Ischemia-Reperfusion Injury In Musculocutaneous Flaps, Handan Derebaşinlioğlu, Anil Demi̇röz, Yağmur Aydin, Hakan Ekmekçi̇, Özlem Balci Ekmekçi̇, Övgü Aydin, Levent Cankorkmaz
Turkish Journal of Medical Sciences
Background/aim: The aim of the study was to evaluate the protective effect of Botulinum A toxin injection against ischemia-reperfusion injury. Materials and methods: Thirty-two Sprague-Dawley rats were divided into: control, ischemia-reperfusion, ischemic preconditioning, and botulinum groups. In all groups the musculocutaneous pedicle flap was occluded for 4 h, and then reperfused to induce ischemia- reperfusion injury. Serum and tissue myeloperoxidase (MPO) and nitric oxide (NO) levels were measured at 24 h and at 10 days. Results: Tissue MPO levels did not differ significantly between the ischemic preconditioning and botulinum groups at 24 h but was significantly lower in the botulinum …