Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 2 of 2
Full-Text Articles in Medicine and Health Sciences
Levels Of Nitric Oxide, Asymmetric Dimethyl Arginine, Symmetric Dimethyl Arginine,And L-Arginine In Patients With Obsessive-Compulsive Disorder, Enver Demi̇rel Yilmaz, Mehmet Fati̇h Üstündağ, Ali̇ Görkem Gençer, Yüksel Kivrak, Özge Ünal, Mustafa Bi̇li̇ci̇
Levels Of Nitric Oxide, Asymmetric Dimethyl Arginine, Symmetric Dimethyl Arginine,And L-Arginine In Patients With Obsessive-Compulsive Disorder, Enver Demi̇rel Yilmaz, Mehmet Fati̇h Üstündağ, Ali̇ Görkem Gençer, Yüksel Kivrak, Özge Ünal, Mustafa Bi̇li̇ci̇
Turkish Journal of Medical Sciences
Background/aim: We aimed to investigate and compare to healthy controls the variations in the levels of nitric oxide (NO), asymmetric dimethyl arginine (ADMA), symmetric dimethyl arginine (SDMA), and L-arginine levels in patients with obsessive-compulsive disorder (OCD). Materials and methods: We enrolled 30 patients with OCD and 30 healthy controls in the study consecutively. Diagnostic interviews of all participants were conducted with the Structured Clinical Interview for Axis I Disorders (SCID-I), and sociodemographic data of the participants were recorded. Patients scoring 10 points or more on the Yale-Brown Obsessive-Compulsive Scale were enrolled in the study. Results: The NO levels of patients …
The Effects Of Novokinin, An At2 Agonist, On Blood Pressure, Vascular Responses, And Levels Of Adma, Nadph Oxidase, And Rho Kinase In Hypertension Induced By Nos Inhibition And Salt, Emre Mutlu, Selçuk İlhan, Eli̇f Onat, Murat Kara, Engi̇n Şahna
The Effects Of Novokinin, An At2 Agonist, On Blood Pressure, Vascular Responses, And Levels Of Adma, Nadph Oxidase, And Rho Kinase In Hypertension Induced By Nos Inhibition And Salt, Emre Mutlu, Selçuk İlhan, Eli̇f Onat, Murat Kara, Engi̇n Şahna
Turkish Journal of Medical Sciences
Background/aim: The effects of AT2 receptor agonist novokinin on blood pressure, eNOS, NADPH oxidase, protein arginine methyltransferases (PRMTs), and Rho kinase in hypertension were investigated. Furthermore, in isolated thoracic aorta rings, contractile and dilator responses were studied. Materials and methods: To develop hypertension, L-NAME was administered intraperitoneally and salt was given with tap water (1%) for 4 weeks. Novokinin was administered intraperitoneally for the last 2 weeks. Blood pressures were measured using the tail-cuff method and enzyme levels by real-time polymerase chain reaction in aortic tissues. Results: Blood pressure increased significantly in hypertensive rats. Novokinin reduced the blood pressure in …