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Full-Text Articles in Medicine and Health Sciences
Immunomodulatory Role Of Leptin Treatment In Experimental Sepsis Caused By Gram Negative Bacteria, Cemi̇le Koca, Havva Şahi̇n Kavakli, Özlem Alici
Immunomodulatory Role Of Leptin Treatment In Experimental Sepsis Caused By Gram Negative Bacteria, Cemi̇le Koca, Havva Şahi̇n Kavakli, Özlem Alici
Turkish Journal of Medical Sciences
To investigate the effect of leptin treatment on circulating inflammatory cytokines and on tissue damage in experimental rat model of gram-negative sepsis. Materials and methods: Adult male Wistar rats, 28 in total, were randomly divided into 4 groups (n = 7): sham, leptin, sepsis, and sepsis group treated with leptin (sepsis+leptin). Sepsis was induced by intraperitoneal (ip) injection of 2 × 10^{10} CFU of Escherichia coli ATCC 25922. Leptin and sepsis+leptin groups received a single dose ip 0.1 mg/kg leptin, while sham group received 1 mL of ip saline. Rats were sacrificed 24 h after the induction of sepsis. Blood …
The Protective Effect Of Dexamethasone And Lactate Against Cisplatin-Induced Ototoxicity, Ari̇f Şanli, Sedat Aydin, Zeynep Alev Sarisoy, Mustafa Paksoy, Emi̇n Ayduran, Özlem Çelebi̇ Erdi̇vanli
The Protective Effect Of Dexamethasone And Lactate Against Cisplatin-Induced Ototoxicity, Ari̇f Şanli, Sedat Aydin, Zeynep Alev Sarisoy, Mustafa Paksoy, Emi̇n Ayduran, Özlem Çelebi̇ Erdi̇vanli
Turkish Journal of Medical Sciences
To compare the protective effect of dexamethasone and lactate against cisplatin-induced ototoxicity. Materials and methods: Thirty Wistar rats were randomly divided into 4 groups. After the rats were sedated with intraperitoneal (IP) ketamine hydrochloride (50 mg/kg) and xylazine (7.5 mg/kg), baseline ABRs (auditory brainstem evoked responses) were measured in response to clicks and tone pips of 4, 8, 12, and 16 kHz. After auditory thresholds were determined, the animals received drug administration as follows: Group 1 (n: 6) received intratympanic (IT) saline (0.9% NaCl) solution, Group 2 (n: 8) IP cisplatin (20 mg/kg) alone, Group 3 (n: 8) IT dexamethasone …