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Full-Text Articles in Medicine and Health Sciences
Comparative Histological Analysis Of Hepatitis C Virus With Hepatitis B, Gülen Akyol, Özlem Süer, Cem Sezer
Comparative Histological Analysis Of Hepatitis C Virus With Hepatitis B, Gülen Akyol, Özlem Süer, Cem Sezer
Turkish Journal of Medical Sciences
Aims: Rates of certain histopathologic features were evaluated in hepatitis C and in hepatitis B materials and analyzed statistically in a Turkish population. Method: The presence of lymphoid aggregate, steatosis, ductal lesions, sinusoidal inflammation and portal iron deposition were investigated in 80 hepatitis C and 104 hepatitis B specimens and evaluated using the chi-square test and Fisher's exact test. Pan Band T cell markers were used for lymphoid aggregate analysis. P53 and PCNA were applied for the possible impact of steatosis on cell biology. Results: All mentioned parameters excluding sinusoidal inflammation were found to be higher in hepatitis C samples. …
Molecular Genetics Of Breast Cancer, Emel Ergül, Ali̇ Sazci
Molecular Genetics Of Breast Cancer, Emel Ergül, Ali̇ Sazci
Turkish Journal of Medical Sciences
Recent advances in molecular biology enable researchers to understand the basis of breast cancer much better and show that hereditery breast cancer may result from mutations on several specific gene loci including BRCA1, BRCA2, p53, ATM and PTEN. These genes are tumor supressor genes and although their functions are different, they are all involved in the maintenance of genomic stability after DNA damage. Mutations that impair the function of these genes may adversely affect the manner in which DNA damage is processed. It is likely that the risk of breast cancer development is increased through this mechanism. Moreover, there are …