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Investigation Of Some Immune System Parameters And Gfap Immunoreactivity In Convulsive And Non-Convulsive Seizures In Rats, Ni̇lüfer Esen, Yeşi̇m Gürbüz, Deni̇z Şahi̇n, Nurbay Ateş
Investigation Of Some Immune System Parameters And Gfap Immunoreactivity In Convulsive And Non-Convulsive Seizures In Rats, Ni̇lüfer Esen, Yeşi̇m Gürbüz, Deni̇z Şahi̇n, Nurbay Ateş
Turkish Journal of Medical Sciences
The aim of this study was to investigate the systemic humoral and cell-mediated immune system parameters, and glial fibrillary acidic protein (GFAP) immunoreactivity in non-convulsive absence epilepsy and pentylenetetrazole (PTZ)- induced generalized tonic-clonic seizures. Animals were divided into three groups: i. the control group, ii. the genetic absence epilepsy WAG/Rij group, and iii. the chronic generalized tonic-clonic convulsion group injected with PTZ. After the experimental procedure, blood samples were collected intracardially, and CD3+ (T cells), CD4+ (T helper), CD8+ (T cytotoxic), CD19+ (B cells) and CD25+ (IL-2 reseptor, active T cell) cell ratios were determined by indirect immunoflourescence in FACScan, …