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The Role Of Apob-Containing Lipoproteins In Abdominal Aortic Aneurysm, Jing Liu
The Role Of Apob-Containing Lipoproteins In Abdominal Aortic Aneurysm, Jing Liu
Theses and Dissertations--Pharmacology and Nutritional Sciences
Abdominal aortic aneurysm (AAA) is a devastating disease that exhibits permanent lumen expansion typically in the infrarenal aorta. AAA is prevalent among aged population, especially in males. Despite the incidence in women is lower, studies indicate the tortuosity is more severe and aortic rupture risk is higher in women. In most patients, AAA remains asymptomatic until it ruptures leading to sudden and fatal hemorrhage.
To date, there is no proven medical therapy that can prevent the expansion or rupture. Human observational studies implicate the presence of AAA is associated with both high plasma low-density lipoprotein-cholesterol (HDL-C) and low plasma high-density …