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Full-Text Articles in Medicine and Health Sciences
The Effects Of Antibodies In Disease Progression Of Mog-Induced Experimental Autoimmune Encephalomyelitis, Melissa Marie Riter
The Effects Of Antibodies In Disease Progression Of Mog-Induced Experimental Autoimmune Encephalomyelitis, Melissa Marie Riter
Theses and Dissertations
Abstract: Multiple sclerosis (MS) is an auto-inflammatory disease of the central nervous system (CNS), affecting over 400,000 people in the US. MS is primarily studied in the animal model experimental autoimmune encephalomyelitis (EAE). MS is a T cell mediated disease but there is mounting evidence for a role for B cells in MS. Previous studies have established that rMOG Induction depends on the presence of B cells, while induction using the MOG peptide covering amino acids 35-55 does not require B cells to cause disease. When plasma from the rMOG and MOG35-55 immunized WT mice was analyzed by ELISA there …
The Mechanism Of Suppression By A Protective Peptide In A Mouse Model Of Multiple Sclerosis, Alaa Mansour Almatrook
The Mechanism Of Suppression By A Protective Peptide In A Mouse Model Of Multiple Sclerosis, Alaa Mansour Almatrook
Theses and Dissertations
Multiple Sclerosis (MS) is an autoimmune demyelinating disease of the central nervous system (CNS). MS is characterized by an immune response directed against myelin sheath. This immune response results in demyelination, which leads to the clinical symptoms of MS. It is accepted that MS is mediated by T helper 1/ T helper 17 immune responses. However, the role of B cells and antibodies (Abs) are still under debate. The primary animal model for MS is the experimental autoimmune encephalomyelitis (EAE) that is induced by immunizing animals with one of the myelin components. We previously showed that immunizing mice with the …
Axon Initial Segment Stability In Multiple Sclerosis, Suneel K. Thummala
Axon Initial Segment Stability In Multiple Sclerosis, Suneel K. Thummala
Theses and Dissertations
Multiple sclerosis (MS) is an autoimmune disease of the central nervous system characterized by inflammation and demyelination. In addition to these hallmark features, MS also presents with axonal pathology, which is likely responsible for the signs and symptoms of the disease. Although prominent in MS, axonal pathology is frequently considered a consequence of demyelination and not a primary event. This conclusion is consistent with demyelination inducing the loss of specific axonal domains, known as the nodes of Ranvier that are responsible for the propagation of action potentials along the axon. In contrast, we propose that axonal pathology associated with MS …