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Full-Text Articles in Medicine and Health Sciences
Functional And Phenotypic Analysis Of B- And T-Helper Cells In Rhesus Macaques And African Green Monkeys, Sahar Ali Alhakeem
Functional And Phenotypic Analysis Of B- And T-Helper Cells In Rhesus Macaques And African Green Monkeys, Sahar Ali Alhakeem
Theses and Dissertations
Human immunodeficiency virus (HIV) is one of the most challenging infectious agents at the current time. To date, many vaccine trials have been conducted. However, there has not been a fully successful trial. This is due, in part, to the gap in knowledge of the protective immune response against HIV. African green monkeys (AGMs) serve as an interesting model to study immune protection in primate immunodeficiency virus infections due to their resistance to AIDS. Experimental SIV infection in rhesus macaques (RMs) resembles HIV infection in humans with chronic immune activation and progression to AIDS well characterized in both. Understanding the …
The Influence Of Self-Reported Degree Of Masculinity/Femininity On Condom Use Among Black Men Who Have Sex With Men In The Deep South, Elizabeth D. Peeler
The Influence Of Self-Reported Degree Of Masculinity/Femininity On Condom Use Among Black Men Who Have Sex With Men In The Deep South, Elizabeth D. Peeler
Theses and Dissertations
In the United States, 50,000 Americans are diagnosed with HIV each year (CDCa, 2014). The HIV/AIDS epidemic has had a particularly devastating impact on the southern U.S., especially the Deep South – Alabama, Georgia, Louisiana, Mississippi, North Carolina, and South Carolina (Reif, Whetten, Wilson, McAllaster, Pence, Legrand, & Gong, 2014). The Deep South, while only composing of 36% of the national population, accounts for 50% of all people living with HIV/AIDS in the nation (Human Rights Watch, 2010). No other population has been hit harder than men who have sex with men (MSM; Prejean, Tang, & hall, 2013). Black MSM …
Enhancement Of The Placental Transmission Of Lopinavir Using A Transporter Targeted Prodrug Strategy, Meng Wang
Enhancement Of The Placental Transmission Of Lopinavir Using A Transporter Targeted Prodrug Strategy, Meng Wang
Theses and Dissertations
Lopinavir (LPV) is a potent protease inhibitor specific for HIV-1. However, LPV has poor placental penetration due to substrate activity for efflux transporter by P-glycoprotein (P-gp). Since fatty acid transporters are highly expressed in the placenta during pregnancy, we designed fatty acid ester prodrug of lopinavir as substrates of fatty acid transporter in order to improve their uptake into placenta. Seven dicarboxylic acid esters of lopinavir have been made in our lab. The structures were characterized by 1H-NMR, 13C-NMR, LC-MS/MS, HRMS, IR and melting points. After making the prodrugs, an LC-MS/MS method with high specificity and sensitivity, as …