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Full-Text Articles in Medicine and Health Sciences
Integration And Impact Of Stress Management And Resiliency Training (Smart) In A Nurse Residency Program: A Feasibility Study, Sherry Chesak
Integration And Impact Of Stress Management And Resiliency Training (Smart) In A Nurse Residency Program: A Feasibility Study, Sherry Chesak
Theses and Dissertations
Nursing is recognized widely as a highly stressful profession, and the time of orientation is identified as the most stressful time in a nurse's career. Innovative strategies are needed to assist new registered nurses in the management and prevention of stress as a result of transitioning into the complex and challenging healthcare environment. The purpose of this study was to assess the feasibility and impact of integrating a Stress Management and Resiliency Training (SMART) program within a nurse residency program for new nurses at an academic medical center. Additional aims were to assess the effects of the program on participants' …
Beta 2 Nicotinic Acetylcholine Receptor Contributions To Anxiety-Like Behavior, Shawn Anderson
Beta 2 Nicotinic Acetylcholine Receptor Contributions To Anxiety-Like Behavior, Shawn Anderson
Theses and Dissertations
Nicotine is a major psychoactive ingredient in tobacco that is thought to promote smoking behavior via nicotinic acetylcholine receptors (nAChRs) in the brain. Given reports that people smoke to relieve anxiety and that anxiety precipitates relapse, the overarching goal of this dissertation research is to assess beta 2 subunit containing nAChR (beta2*nAChR) contributions to anxiety-like behavior. Nicotine’s activity at beta2*nAChRs is concentration-dependent, with high concentrations facilitating activation followed by rapid desensitization and low concentrations preferentially desensitizing beta2*nAChRs; hence, activation or inhibition of beta2*nAChRs may support smoking behavior. Rodent studies reveal that nicotine affects anxiety-like behavior dose-dependently: low doses promote anxiolysis- …
Genetic Dissection Of Quantitative Trait Loci For Substances Of Abuse, Jo Lynne Harenza
Genetic Dissection Of Quantitative Trait Loci For Substances Of Abuse, Jo Lynne Harenza
Theses and Dissertations
It has been reported that an individual’s initial level of response to a drug might be predictive of his or her future risk of becoming dependent, thus basal gene expression profiles underlying those drug responses may be informative for both predicting addiction susceptibility and determining targets for intervention. This dissertation research aims to elucidate genetic risk factors underlying acute alcohol and nicotine dependence phenotypes using mouse genetic models of addiction. Phenotyping, brain region-specific mRNA expression profiling, and genetic mapping of a recombinant inbred panel of over 25 mouse strains were performed in order to identify quantitative trait loci (QTL) harboring …
Intrinsic Religiosity And Adolescent Depression And Anxiety: The Mediating Role Of Components Of Self-Regulation, Brent Charles Black
Intrinsic Religiosity And Adolescent Depression And Anxiety: The Mediating Role Of Components Of Self-Regulation, Brent Charles Black
Theses and Dissertations
This study examined the possible mediating role of the emotional, behavioral, and cognitive components of self-regulation as they relate to adolescent intrinsic religiosity and the internalizing problems of teen depression and anxiety. The sample included 459 adolescent respondents from one wave of the Flourishing Families Project, an ongoing longitudinal study. Through the use of Structural Equation Modeling, results showed that cognitive self-regulation partially mediated the relationship between intrinsic religiosity and adolescent depression. Additionally, emotional self-regulation, but not behavioral self-regulation was found to be negatively linked with both depression and anxiety. These findings provide clinicians with greater direction when working with …