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Lipocalin-2 Ameliorates The Signs And Outcomes Of Diabetes Mellitus In An Animal Model, Saeeda Mohammed Al Jaberi Jun 2021

Lipocalin-2 Ameliorates The Signs And Outcomes Of Diabetes Mellitus In An Animal Model, Saeeda Mohammed Al Jaberi

Theses

Lipocalin-2 (LCN2) is a new adipocytokine consisting of 198 amino acids. It is also referred to as neutrophil gelatinase-associated lipocalin, siderocalin, uterocalin, α1-microglobulin related protein, or 24p3. LCN2 belongs to a large group of transport proteins that are capable of carrying small and lipid soluble molecules in blood circulation. It has two membrane receptors, megalin/glycoprotein GP330, which binds human LCN2 and SLC22A17 or 24p3R, which forms complexes with mouse Lcn2 protein. LCN2 is encoded by a gene located at chromosome locus 9q34.11. LCN2 was initially isolated from neutrophil granules released at site of infection and inflammation in human and from …


Lipocalin-2 Ameliorates The Signs And Outcomes Of Diabetes Mellitus In An Animal Model, Saeeda Mohammed Al Jaberi Jun 2021

Lipocalin-2 Ameliorates The Signs And Outcomes Of Diabetes Mellitus In An Animal Model, Saeeda Mohammed Al Jaberi

Theses

Lipocalin-2 (LCN2) is a new adipocytokine consisting of 198 amino acids. It is also referred to as neutrophil gelatinase-associated lipocalin, siderocalin, uterocalin, α1-microglobulin related protein, or 24p3. LCN2 belongs to a large group of transport proteins that are capable of carrying small and lipid-soluble molecules in blood circulation. It has two membrane receptors, megalin/glycoprotein GP330, which binds human LCN2 and SLC22A17 or 24p3R, which forms complexes with mouse Lcn2 protein. LCN2 is encoded by a gene located at chromosome locus 9q34.11. LCN2 was initially isolated from neutrophil granules released at the site of infection and inflammation in humans and from …


Distribution Of Ghrelin In Pancreatic Islet Cells Of Normal And Diabetic Rats And Its Effect On Diabetes Mellitus, Haba Y. M. El Abadlah May 2015

Distribution Of Ghrelin In Pancreatic Islet Cells Of Normal And Diabetic Rats And Its Effect On Diabetes Mellitus, Haba Y. M. El Abadlah

Theses

Ghrelin, a 28-amino acid peptide, is identified as the endogenous ligand of the orphan growth hormone secretagogue-receptor type 1a. Ghrelin presents a unique modification at Ser3 position essential for its activity. It was first discovered in the stomach of rat in 1999. Aside from ghrelin’s role as a potent growth hormone secretagogue and food intake modulator, ghrelin is thought to play a role in insulin and glucagon secretion and in glucose homeostasis. A lot of contradictory data have been reported in the literature regarding ghrelins co-localization with other hormones in the islets of Langerhans, its role in insulin secretion and …