Medicine and Health Sciences Commons^™

Transdermal And Transbuccal Delivery Of Lidocaine And Nicotine : Combined Effects Of Iontophoresis And Chemical Enhancers, Ran Wei

Theses

This study focused on the effects of iontophoresis and chemical enhancers on drug release. The transport of Lidocaine HCl (LHCl) and Nicotine Hydrogen Tartrate (NHT) through the skin and mucosa was evaluated for potential clinical applications. These two potential delivery routes have the advantage of avoiding first-pass effect. Samples were pretreated with enhancer solutions for one hour before the experiments. Passive or 0.3 mA iontophoresis-assisted drug diffusion was conducted for 8 hours to monitor the cumulative amount of drug released. Graphical methods and mathematical optimization techniques were implemented to analyze the data. The effects of chemical enhancers on the delivery …

Dissolution Testing Of Prednisone And Salicylic Acid Calibrator Tablets At Different Tablet Locations, Anandhavalavan Arulmozhi

Theses

Dissolution testing is routinely carried out in the pharmaceutical industry to determine the rate of dissolution of solid dosage forms. This test is one of the several tests that pharmaceutical companies typically conduct on oral dosage formulations (e.g., tablets) to determine compliance. The USP Dissolution Testing Apparatus 2 is the most common of the apparatuses listed in the USP. However, it has been shown previously that the dissolution profile of a tablet undergoing dissolution in the USP Dissolution Apparatus 2 can be affected by the tablet location in the apparatus.

In this work, the dissolution rates of both non-disintegrating tablets …

Dissolution Of Disintegrating Solid Dosage Forms In A Modified Dissolution Testing Apparatus 2, Shrutiben Rameshbhai Parekh

Theses

Dissolution tests are routinely carried out in the pharmaceutical industry to determine the dissolution rate of solid dosage forms. Dissolution testing serves as a surrogate for drug bioavailability through in vitro–in vivo correlation (IVIVR), and it additionally helps in guiding the development of new formulations and in assessing lot-to-lot consistency, thus ensuring product quality. The United States Pharmacopoeia (USP) Dissolution Testing Apparatus 2 is the device most commonly used for this purpose. Despite its widespread use, dissolution testing using this apparatus remains susceptible to significant error and test failures. There is documented evidence that this apparatus is sensitive to several …

Biomechanical Analysis Of Asymmetric And Dynamic Lifting Task, Xiaopeng Jiang

Theses

Lifting tasks is one of the leading causes of occupational lower back disorders (LBD). Aimed at deriving internal forces of human musculoskeletal system during lifting, biomechanical models are utilized to address this problem. This thesis provides an indepth literature review of such modeling, and the results of experiments used to address LBD issues.

An isometric pulling experiment was conducted to study the correlation between electromyography (EMG) and predicted muscle forces by AnyBody Modeling System™ with increasing hand loads. An infinite order polynomial (min/max) optimization criterion predicted percentage of maximum muscle forces, which achieved 98% correlation with normalized EMG. In a …

The Effects Of Culturally Sensitive Education In Driving South Asian Indian Immigrant Women Towards Mammography Screening In New Jersey, Elise Elizabeth Kumar

Theses

Background & Purpose of the Study: Breast Cancer is the most commonly diagnosed form of cancer, and is becoming a major public health issue concern for many South Asian Indian immigrant women. However, women of ethnic subgroups and those who immigrated to the United States within the last ten years are less likely to have had a recent mammogram. The purpose of this study is to evaluate a culturally sensitive breast cancer educational intervention on breast cancer knowledge, perception of cancer fatalism, and improved participation in mammography screening among South Asian Indian immigrant women. Methods: Utilizing a quasi -experimental pretest/post …

Non-Traditional Choices: The Construction Of Masculine Identity Among Male Nursing Students, Tim Mackellar

Theses

This purpose of this project was to examine the experiences of five male nursing students, to uncover the challenges involved with reconciling the perceived feminine nature of their occupation with the demands of a traditional masculine gender regime. The research was based within a social constructionist epistemological paradigm, employing a critical theory interpretation and grounded theory methodology. Conducted through semi-structured interviews, the participant’s accounts demonstrated the ways in which they modified, rejected and generally re-conceptualised dominant masculinities within the non-traditional setting. Their experiences were captured through three dominant themes; script assessment, self-authorship and authenticity. Emerging from these themes was a …

Extra Food Intake And Depressive Symptoms In Adolescents: Is There A Relationship?, Elizabeth Bradshaw

Theses

This pilot study explored the potential role of food on young people’s mental health. Specifically, the aim was to determine if a relationship exists between extra food intake and depressive symptoms in adolescents’ age 12-17 years. It has been documented that mental health problems in young people result from a complex interaction of risk and protective factors. Eating behaviours and food intake has been investigated in early adolescence (age 10-14), however the specific contribution of extra food on depressive symptoms in mid adolescence has not been determined.

Extra food intake and depressive symptoms were collected from girls and boys in …

Increasing Organ Donation In Ireland : Social Marketing And Infrastructural Improvements., Ronan O'Sullivan

Theses

There were over 600 patients on the organ waiting list in Ireland in November 2010. This is a substantial increase on the 414 patients on the waiting list in 2008. Ireland also witnessed a dramatic decline in the number of donors from 90 donors in 2009 to 58 donors in 2010. This thesis focuses on investigating the current state of organ donation in the Republic of Ireland, with the eventual goal of recommending alterations to improve the system. In depth- interviews were conducted with eleven leading personnel from the fields of organ donation and social marketing in Ireland as well …

Composition - Structure - Property Relationships In Strontium / Zinc Doped Glass-Ceramics., Mark Looney

Theses

Calcium silicate ceramics are amongst a group of ceramic materials currently utilised as bone graft materials. However, current calcium silicate grafts offer little therapeutic potential and poor mechanical properties. The objective of this project was to examine the composition-structure-property relationships arising from the incorporation of therapeutic ions of strontium (Sr) and zinc (Zn) into calcium silicate glass-ceramics (GC) in order to allow for healthy bone regeneration and antibacterial efficacy. Five compositions were studied with varying mole fractions of Sr and Zn. The GC’s were characterised using differential scanning calorimetry (DSC), x-ray diffraction (XRD) at room and ascending temperatures, x-ray tomography …

Perspectives Of Women In Leadership Roles: Working Through The Change, Philippa Gavranich

Theses

The majority of women will experience perimenopausal symptoms (Hickey, Davis & Sturdee, 2005; MacLennan, 2009) with an estimated 20% of those experiencing severe symptoms (Hickey et al., 2005). Many of these symptoms have the potential to directly or indirectly affect work performance including hot flushes and night sweats which are experienced by 85% of perimenopausal women (Baldo, Schneider, & Slyter, 2003). Symptoms may begin several years before the cessation of menstruation and may last well into old age (MacLennan, 2009).

This research sought to explore the perceived impact of perimenopausal symptoms on women in leadership roles: how they managed symptoms; …