Medicine and Health Sciences Commons^™

Experimental Investigation Of The Fluid Velocity Distribution In Stirred Tank Reactors Equipped With Retreat-Blade Impellers Using Laser Doppler Velocimetry, Deepak Rajesh Madhrani

Theses

Stirred tank reactors are commonly used in the pharmaceutical industry for synthesis of Active Pharmaceutical Ingredients (API's) and their intermediates. Typically, these vessels are glass-lined and are provided with a single retreat-blade glass-lined impeller and a single baffle. Despite their ubiquitous utilization in the pharmaceutical industry for at least the past 40 years, the mixing characteristics of these systems have not been studied to any great extent, making it difficult to predict mixing performance in any given operation.

In this work, the velocity distribution inside the typical glass-lined vessel/impeller system was experimentally quantified using Laser Doppler Velocimetry (LDV), which is …

Long Driving Hours And Health Of Truck Drivers, Stephen J. Benstowe

Theses

In recent time, the health of truck drivers has become a concern for regulatory agencies and safety professionals all over the world. Fatal and non-fatal injury rates for truck drivers are among the highest of all occupations. Truck driving is an important and tedious job. Driving for long hours, drivers are confined to a small space, sit with static lower and upper extremities posture, mentally focus and absorb vibrations.

This thesis provides an in-depth review of the literature related to the problems of long distance truck drivers and commercial motor vehicle operators. The Literature suggests that continuous exposure of truck …

Ultra-Fine Particle Formation Using Principle Of Rapid Expansion Of Supercritical Solutions`, Miraj Minesh Sheth

Theses

There are indications in the chemical and pharmaceutical industries that the reduction in size of a crystalline particle can lead to better performance of the drug compound, particularly for water insoluble drugs, in the final dosage form. Many particle formation techniques have been investigated in recent years by researchers to obtain desired particulate sizes and size distributions. Supercritical fluid technologies have been successfully investigated for particle formation due to its unique gas/liquid properties in the supereritical state. In this report, results of particle formation using the principles of Rapid Expansion of Supercritical Solutions (RESS) have been documented.

In the RESS …

The Influence Of Health Inquiries On Clinical Governance Systems: A Case Study Of The Douglas Inquiry, Heather Gluyas

Theses

Major failures in patient safety often lead to high profile inquiries set up to establish the facts, and to identify areas of improvement to prevent further failures. In order to learn from inquiries, we need to be able to identify if, and how, the inquiry process influences improvements. Using a case study strategy, this research study examined the perceptions of external stakeholders in regards to the impact or influence of the Douglas Inquiry on KEMH’s clinical governance systems. The research focused on two areas that were highlighted in the final Inquiry report as requiring reform. These systems deal with the …

Implementing A Forensic Educational Package For Registered Nurses In Two Emergency Departments In Western Australia, Christine M. Michel

Theses

The results of violence are a major public health problem that infiltrates hospital emergency departments (ED) daily. Often, ED nurses are the first healthcare professionals to see patients, speak with family members, handle personal property and collect laboratory specimens. Such actions can be of extreme importance to the 27 different categories of forensic patients. To adequately address forensic patient issues, ED nurses need exposure to forensic education. The aim of this research was to develop and evaluate the effectiveness of a clinical forensic education package on ED nurses’ perceptions, knowledge and care of forensic patients. To accomplish this aim, this …

Treatment Of Industrial Wastewater Containing Active Pharmaceutical Ingredients With A Membrane Bioreactor, With The Aim Of Reducing Resource Consumption, Pádraig Colm Ó'Maolcatha

Theses

The biodegradation of a selected active pharmaceutical ingredient (API) during wastewater treatment in a membrane bioreactor (MBR) was examined experimentally. A comparison study was conducted by operating a conventional activated sludge (CAS) pilot plant in parallel to the MBR. The MBR was operated under varying conditions of pH (pH6 and pH8), MLSS (6g/L and l0g/L) and SRT (20 days and 30 days) according to a full factorial design of experiments. In the CAS, pH and SRT were altered as above but MLSS was maintained at 3-4g/L. Comparable average API removal results of 95.5% and 95.7% were obtained for the MBR …

Urine Protein Electrophoresis: Comparison Of Agarose Gel And Capillary Zone Electrophoretic Techniques., Anne-Marie Curtin

Theses

Proteinuria is the excess excretion of protein in the urine and is found in a variety of conditions including renal diseases and neoplastic conditions such as multiple myeloma (MM). The investigation of proteinuria type through the use of electrophoresis is a useful and widely used non-invasive diagnostic tool. The aim of this study was to compare various agarose gel and capillary zone electrophoresis techniques in order to establish a method choice for the separation of protein in routine laboratories. Comparisons were made based on urine monoclonal peak quantification and protein fractions detected. An examination of a capillary zone electrophoresis (CZE) …

An Investigation Into The I-Stat Chem8+ System For The Measurement Of Sodium, Potassium, Urea & Creatinine., Gene Ferris

Theses

In the hospital environment Point of Care Testing (POCT) can be an invaluable tool in Emergency departments, Theatres, Intensive Care Units and Paediatric wards by providing rapid test results without the need for transport and laboratory processing. The study design included the collection and duplicate analysis of patient samples firstly using the i-STAT and then on the Architect c8000, a routine laboratory analyser. Statistical analysis was performed in order to determine if there is a statistically significant difference in results between the i-STAT POCT system and current laboratory instrumentation. The parameters analysed were the vital biochemical parameters Sodium (Na), Potassium …

Art Therapy Student Placement : Challenge And Opportunity?, Niamh Kennedy

Theses

The purpose of this research project is to explore the sector of Student Placement as it forms a significant part of the training programme on the MA in Art Therapy in Cork. The study aims to assess the effectiveness of this part of the educational process for trainees and investigate the impact the Clinical Placement experience has on Student Art Therapists.

By reflecting on the advancement of Art Therapy in our neighbouring isle and exploring the growth of Art Therapy as a profession in the Republic of Ireland, this study aims to chronicle a more recent Irish history of Art …

Detection And Molecular Epidemiological Analysis Of Acute Gastroenteritis Viruses In The South Of Ireland, Grainne Lennon

Theses

Rotavirus infections are considered to be the most common cause of severe gastroenteritis in children under the age of 5 years, and are responsible for up to 611,000 deaths annually, mainly in developing countries. From 1997 to 1999, 16 hospital laboratories in the Republic of Ireland reported to detection of 4,643 cases of rotaviral disease, while in 2004 and 2005 and increase of 1,600 and 2,251 rotavirus cases were reported. These rotavirus cases have a significant impact on the healthcare system with the minimum cost per case being €728.40. A large percentage of the infections were reported in neonates, suggesting …

Gender Bias Of Cardiovascular Risk In Caucasian Type Ii Diabetics: A Haemostatic Explanation?, William Quirke

Theses

People with type II diabetes are disproportionately affected by cardiovascular disease compared to those without diabetes. The relative risk of cardiovascular disease caused by type II diabetes is higher in females than in males. This risk has not been fully explained by traditional risk factors and attention has turned to the possible role of haemostatic abnormalities in explaining the excess cardiovascular morbidity and mortality among diabetic females. We examined specific parameters of the coagulation (factor VII, factor VIII, von Willebrand factor, fibrinogen) and fibrinolytic (plasminogen activator inhibitor- 1, thrombin-activatable fibrinolysis inhibitor) system in 113 Irish Caucasian type II diabetics to …