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Subcutaneous Implantation Of The Light-Activated Pit And Fissure Resin-Based Sealant Prototypes Las-Clear And Las-Opaque Resulted In A Mild Transient Tissue Reaction, Pasutha Thunyakitpisal, Nonglax Thunyakitpisal, Dyna Jeanne D. Godoy, Onusa Saravari, Dujreutai Pongkao Kashima, Benchaphorn Limcharoen, Wijit Banlunara

The Thai Journal of Veterinary Medicine

The objective of this study was to evaluate the biocompatibility of the light-activated pit and fissure resin-based dental sealant prototypes, LAS-clear and LAS-opaque, after subcutaneous implantation in rats for 7, 30, and 60 days. The commercial light-activated resin-based sealants, Delton-clear (DC), Helioseal clear (HC), Helioseal opaque (HO), and Clinpro Sealant (CL) served as control. Twenty-four 8-week-old male Sprague-Dawley rats were used in this study. Two rows of three 5 mm subcutaneous incisions were created on the back of each rat parallel to the midline. The materials were randomly implanted and the incisions were closed using sutures. The implants were left …