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Renoprotective Effects Of Megadose Vitamin C On Cisplatin-Induced Kidney Injury, Supa Sithanukul, Chollada Buranakarl, Chutamas Benjanirut, Anudep Rungsipipat
Renoprotective Effects Of Megadose Vitamin C On Cisplatin-Induced Kidney Injury, Supa Sithanukul, Chollada Buranakarl, Chutamas Benjanirut, Anudep Rungsipipat
The Thai Journal of Veterinary Medicine
Cisplatin (CDDP)-induced nephrotoxicity is mediated via oxidative stress and may be alleviated using antioxidant activity. Although megadose of vitamin C may cause oxalate nephropathy and apoptosis, the antioxidant effect of vitamin C may be beneficial when given along with CDDP. The objective of this study was to investigate the renoprotective effects of megadose vitamin C on rats receiving CDDP. Rats were divided into 4 groups: group 1, control rats (CONT); group 2, vitamin C-treated rats (VIT C); group 3, CDDP-treated rats (CDDP) and group 4, CDDP + vitamin C-treated rats (CDDP + VIT C). Vitamin C (1000 mg/kg) was given …